Efficacies of vitamin D and omega-3 polyunsaturated fatty acids on experimental endometriosis

Akyol, Alpaslan; Şimşek, Memet; Ilhan, Rasit; Can, Behzat; Başpınar, Melike Mercan; Akyol, Hadice; Gül, Hüseyin Fatih; Gürsu, Ferit; Kavak, Burçin; Akın, Mustafa

doi:10.1016/j.tjog.2015.06.018

Cited by 35 publications

(42 citation statements)

References 17 publications

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“…In particular, the 12/15-12/15-lipoxygenase-pathway metabolites of eicosapentaenoic acid seem to be important mediators to suppress the progression of implants (150). A further study in rat showed that omega-3 polyunsaturated fatty acids induced lesions regression more than 1,25dihydroxyvitamin-D3 (151). A cohort of women with endometriosis was treated for three months with a combination of antioxidants, including omega -3 and-6 fatty acids.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Investigational drugs for the treatment of endometriosis, an update on recent developments

Barra

Scala

Mais

et al. 2018

Expert Opinion on Investigational Drugs

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Endometriosis is a hormone-dependent benign chronic disease that requires a chronic medical therapy. Although currently available drugs are efficacious in treating endometriosis-related pain, some women experience partial or no improvement. Moreover, the recurrence of symptoms is expected after discontinuation of the therapies. Currently, new drugs are under intense clinical investigation for the treatment of endometriosis. Areas covered: This review aims to offer the reader a complete and updated overview on new investigational drugs and early molecular targets for the treatment of endometriosis. The authors describe the pre-clinical and clinical development of these agents. Expert opinion: Among the drugs under investigation, late clinical trials on gonadotropin-releasing hormone antagonists (GnRH-ant) showed the most promising results for the treatment of endometriosis. Aromatase inhibitors (AIs) are efficacious in treating endometriosis related pain symptoms but they cause significant adverse effects that limit their long-term use. New targets have been identified to produce drugs for the treatment of endometriosis, but the majority of these new compounds have only been investigated in laboratory studies or early clinical trials. Thus, further clinical research is required in order to elucidate their efficacy and safety in human.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Investigational drugs for the treatment of endometriosis, an update on recent developments

Barra

Scala

Mais

et al. 2018

Expert Opinion on Investigational Drugs

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“…4–6 Additionally, the vitamin has been implicated in a number of pathologies affecting women, 7,8 including polycystic ovary syndrome (PCOS), 9–11 yet little is known about how it affects androgen homeostasis in premenopausal, eumenorrheic women.…”

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confidence: 99%

Vitamin D is associated with bioavailability of androgens in eumenorrheic women with prior pregnancy loss

Kuhr

Sjaarda

Alkhalaf

et al. 2018

American Journal of Obstetrics and Gynecology

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BACKGROUND: Prior studies have reported mixed results regarding relationships between vitamin D, androgens, and sex hormone—binding globulin in patients with polycystic ovary syndrome. However, less is known regarding these associations in eumenorrheic, premenopausal women. OBJECTIVE: Our objective was to study the relationships between serum vitamin D and androgen biomarkers in eumenorrheic women with a history of pregnancy loss who were attempting pregnancy. STUDY DESIGN: This was an analysis of a cohort of 1191 participants from the Effects of Aspirin in Gestation and Reproduction trial (2006e2012). Participants were attempting to conceive, aged 18—40 years, with 1—2 documented prior pregnancy losses and no history of infertility, and recruited from 4 academic medical centers in the United States. Serum vitamin D (25-hydroxyvitamin D) and hormone concentrations were measured at baseline. RESULTS: Vitamin D concentration was negatively associated with free androgen index (percentage change [95% confidence interval, —5% (—8% to —2%)] per 10 ng/mL increase) and positively associated with sex hormone—binding globulin (95% confidence interval, 4% [2—7%]), although not with total testosterone, free testosterone, or dehydroepiandrosterone sulfate after adjusting for age, body mass index, smoking status, race, income, education, physical activity, and season of blood draw. CONCLUSION: Overall, vitamin D was associated with sex hormone—binding globulin and free androgen index in eumenorrheic women with prior pregnancy loss, suggesting that vitamin D may play a role in the bioavailability of androgens in eumenorrheic women. We are limited in making assessments regarding directionality, given the cross-sectional nature of our study.

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“…Akyol et al [34] исследовали влияние ви-тамина D и омега-3 ПНЖК (полиненасыщен-ных жирных кислот) на экспериментально ин-дуцированный эндометриоз на модели крыс. Слепое рандомизированное контролируемое экспериментальное исследование было про-ведено на 30 самках крыс Wistar.…”

Section: данные о роли витамина D в патогенезе наружного генитальногоunclassified

“…Уровни IL-6, TNF-α и ва-скуло-эндотелиального фактора роста (VEGF) в перитонеальной жидкости также были зна-чительно снижены в конце лечения в группе, получавшей омега-3. В группе, получавшей ви-тамин D, значительно снижен был только уро-вень IL-6 [34].…”

Section: данные о роли витамина D в патогенезе наружного генитальногоunclassified

The role of vitamin D in the pathogenesis of genital endometriosis

Denisova

Yarmolinskaya

2017

Z.akus.zen.bolezn

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The influence of vitamin D on the women’s health is undeniable. Here we review the modern classification of vitamin D forms and receptors, the current understanding of genomic and non-genomic regulation pathways of vitamin D synthesis. It was found that a vitamin D deficiency related to the development of many diseases, negative impact on reproductive function and pregnancy outcomes. Nowadays, vitamin D is concerned as a prohormone that has multiple effects. Special attention is given to the role of vitamin D in the pathogenesis of genital endometriosis. It is known that vitamin D has anti-inflammatory, antiproliferative and immunomodulating effects, which allow it to be considered as a forward-looking target therapy in endometriosis.

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Efficacies of vitamin D and omega-3 polyunsaturated fatty acids on experimental endometriosis

Abstract: Omega-3 PUFA caused significant regression of endometriotic implants. Vitamin D has not been as effective as omega-3 PUFA on endometriosis.

Cited by 35 publications

References 17 publications

Investigational drugs for the treatment of endometriosis, an update on recent developments

Investigational drugs for the treatment of endometriosis, an update on recent developments

Vitamin D is associated with bioavailability of androgens in eumenorrheic women with prior pregnancy loss

The role of vitamin D in the pathogenesis of genital endometriosis

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