Efficacious formulation of anti-malarial dry suspension for pediatric use

Abstract

This study was designed for concealing the bitter taste of an anti-malarial drug, artemether, by using various coating substances. Four granular formulations (formulations A, B, C and D) of artemether were prepared using different excipients and then were coated using methocil™ E5 and opadry ® enteric solutions in a simple coating pan. In the initial 2 min, the cumulative percentage amount of drug release in phosphate buffer at pH 6.8 from pure artemether and formulation A, B, C and D was 59.4 ± 4.2, 55.7 ± 3.5, 48.2 ± 3.8, 43.4 ± 4.1 and 30.8 ± 3.7, respectively. Formulation D exhibited minimum bitterness as its taste masking efficacy (44.73 ± 4.98) was significantly (P < 0.05) greater than other formulations. It can be concluded from results that granules of formulation D prepared by sodium metabisulphite and methyl paraben sodium and coated by opadry ® enteric had maximally reduced the bitterness of artemether with suitable dissolution behavior.

Developments in Taste-Masking Techniques for Traditional Chinese Medicines

“…Correspondingly, manual taste perception evaluation indicated that the bitter taste intensity score of Opadry ® Enteric-coated granules was much lower than that of Methocil™ E5-coated granules (47.3 vs. 80.5), further confirming the superior taste-masking effect of the Opadry ® Enteric coating. In another investigation, the same two coating materials were also used to enclose particles of a dry suspension containing another artemisinin derivative (named artemether) for taste-masking [ 40 ]. Similarly, the superior taste-masking effect was achieved by the Opadry ® Enteric coating.…”

The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension

“…One of the methods to achieve the maximum taste masking characteristic is to formulate the drug in suspension form which creates a physical fence around the drug [15, 16]. The objective of this work was to formulate acetaminophen as a relatively stable liquid form and study the influence of different polymers such as CMC, Veegum, tragacanth, and PVP on its rheologic characteristics.…”