Efficacité du phloroglucinol sur le raccourcissement de la phase active du travail à la maternité de l'Hôpital Central de Yaoundé, Cameroun

Effects of phloroglucinol on the active phase of labour (EPAL trial): a single blinded randomised controlled trial in a tertiary hospital in sub-Sahara Africa

“…This was however not statistically significant (p value = 0.322). This is similar to studies done in Cameroon by Fouedjio et al [ 11 ] where the rate of cervical dilatation was about 0.5cm/hour faster in the phloroglucinol group compared to the treatment group and to studies conducted in other developing countries where the rate was about 0.8cm/hour in favour of the phloroglucinol group [ 10 ]. This translates and confirms the assertion that labour is faster in parturient with phloroglucinol compared to those without phloroglucinol as the faster the rate of cervical dilatation, the faster the labour.…”

“…This go to confirm that phloroglucinol has no effect on the foetus. This had earlier been confirmed by similar studies [ 10 , 11 ]. The main limitation of the present study was that we included only healthy singleton pregnancies and that the study was a single blinded and carried out in a single centre, the investigators/data collectors could be influenced by the fact that they were aware of the participants on phloroglucinol and those on placebo.…”

“…However, there is paucity of data on the use of this drug to accelerate labour. Few studies conducted within the past decade have shown promising results in decreasing the duration of labour and increasing the rate of cervical dilatation [ 10 , 11 ]. To the best of our knowledge, no randomised controlled trial (RCT) regarding the use of this drug and it relationship with the duration of labour have been conducted in sub-Sahara Africa.…”

“…To the best of our knowledge, no randomised controlled trial (RCT) regarding the use of this drug and it relationship with the duration of labour have been conducted in sub-Sahara Africa. The only available RCT conducted in Yaoundé, Cameroon by Fouedjio et al evaluated the effects of phoroglucinol on the rate of cervical dilatation and not the duration of labour [ 11 ]. The main aim of this study was to investigate the effects of phloroglucionol on the duration of labour and the rate of cervical dilatation.…”

Optimization of a Method for the Simultaneous Determination of Phloroglucinol and Trimethylphloroglucinol by High Performance Liquid Chromatography in Routine Use in a Pharmaceutical Industry in Abidjan

“…developed by many manufacturers in several pharmaceutical specialities is no exception to this plague [1] [2] [3] [5]. These molecules have an important place in the management of pain caused by muscle spasms, particularly in gynaecology [6] [7]. They are not only used in gynaecology, but also in the symptomatic treatment of pain related to functional disorders of the digestive tract [8], the biliary tract [9], in spasmodic manifestations and in acute pain of the urinary tract (renal colic) [10] [11].…”