Efficacy and acceptability of 0.074% diclofenac-containing mouthwash after periodontal surgery: A clinical study

Agarwal, Sangita; Mathur, Setu; Kothiwale, Shaila; Benjamin, Amit

doi:10.4103/0970-9290.70814

Cited by 11 publications

(22 citation statements)

References 7 publications

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“…NSAIDs reduce the production of prostaglandins[ Table 1]that sensitize nerve endings at the site of injury. Clinical trials have shown that NSAIDs are effective in the management of any level of dental pain, whether mild, moderate or severe 13 .The most commonly used topical analgesics in oral mucosal pain are choline salicylate, benzydamine, benzalkonium chloride and diclofenac sodium.…”

Section: Non-steroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

“…3% diclofenac in 2.5% hyaluronan was an effective treatment for common, painful disorder Recurrent aphthous stomatitis according to Iraji et al 16 . Sangita et al showed that 0.074% diclofenac mouthwash is an effective and tolerable medicinal product for post-surgical symptomatic relief 13 .VOLINI GEL ® (DiclofenacDiethylamine BP 1.16% w/w) is indicated for relief from pain, swelling and inflammation due to joint pain, low back pain, neck pain & shoulder pain, minor sports injury, sprains & sprains. In dentistry it is used to relieve pain caused by tempromandibular disorders.…”

Section: Figure4 Mechanism Of Action Of Nsaidsmentioning

confidence: 99%

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Ağrı Kesici Olarak Topikal İlaçlar

Srinivasan¹,

Shenai²,

Chatra³

et al. 2015

Arşiv Kaynak Tarama Dergisi

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Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect. Key words: Topical therapy, topical analgesics, topical antibiotics, topical anesthetics, topical corticosteroids, drugs. ÖZET

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Section: Non-steroidal Anti-inflammatory Drugs (Nsaids)mentioning

confidence: 99%

Section: Figure4 Mechanism Of Action Of Nsaidsmentioning

confidence: 99%

Ağrı Kesici Olarak Topikal İlaçlar

Srinivasan¹,

Shenai²,

Chatra³

et al. 2015

Arşiv Kaynak Tarama Dergisi

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“…Diclofenac mouthwash is useful in administration for postoperative pain after periodontal surgery [7][8][9] and shows a very good safety in the treatment 8,10 . This medicine showed positive results on pharyngodynia and odynophagia 11 , in symptomatic relief in all types of aphthous ulceration 12 .…”

Section: Introductionmentioning

confidence: 99%

New approaches to the synthesis of diclofenac choline

Dąbrowska-Maś¹,

Raś²

2017

10.5267/j.ccl

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The process described herein proceeds to obtaining diclofenac choline from choline bicarbonate and diclofenac acid in mild conditions, using non-toxic solvent, with the same impurity profile deriving from diclofenac particle as for diclofenac sodium EP. The substance is also substantially free from impurities deriving from choline and free from inorganic byproducts, what means that the quality may be accepted for use as an active substance in medicine.

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“…However, the systemic use of these drugs is commonly associated with side effects, impairing patients’ compliance to their consumption [16]. Although the local utilization of NSAIDs and other anti-inflammatory agents has been examined in some studies, many of them have revealed unsatisfactory results in controlling inflammation when these drugs are topically administrated [17-19]. …”

Section: Introductionmentioning

confidence: 99%

Protective effect of topical Cordia verbenacea in a rat periodontitis model: immune-inflammatory, antibacterial and morphometric assays

Pimentel

Barrella

Casarin

et al. 2012

BMC Complement Altern Med

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BackgroundThis study evaluated the effects of C. verbenacea essential oil topically administered in a rat periodontitis model.MethodsPeriodontitis was induced on rats in one of the mandibular first molars assigned to receive a ligature. Animals were randomly divided into two groups: a) non-treatment group (NT) (n = 18): animals received 1mL of vehicle; b) C. verbenacea group (C.v.) (n = 18): animals received 5mg/Kg of essential oils isolated from C. verbenacea. The therapies were administered topically 3 times daily for 11 days. Then, the specimens were processed for morphometric analysis of bone loss. The ligatures were used for microbiological assessment of the presence of Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Porphyromonas gingivalis using PCR. The gingival tissue was collected to Elisa assay of interleukin (IL)-1α and IL-10 levels.ResultsBone loss was inhibited by C. verbenacea when compared to the NT group (p < 0.05). A decrease in the levels of IL-1α and increase in the IL-10 amounts was observed in the C.v. group as compared to NT group (p < 0.05). A lower frequency of P. gingivalis was found in C.v. group (p < 0.05).ConclusionC. verbenacea essential oil topically administered diminished alveolar bone resorption, promoting a positive local imbalance in the pro/anti-inflammatory system and reducing the frequency of detection of P. gingivalis.

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Efficacy and acceptability of 0.074% diclofenac-containing mouthwash after periodontal surgery: A clinical study

Abstract: The new 0.074% diclofenac mouthwash is an effective and tolerable medicinal product for post-surgical symptomatic relief.

Cited by 11 publications

References 7 publications

Ağrı Kesici Olarak Topikal İlaçlar

Ağrı Kesici Olarak Topikal İlaçlar

New approaches to the synthesis of diclofenac choline

Protective effect of topical Cordia verbenacea in a rat periodontitis model: immune-inflammatory, antibacterial and morphometric assays

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