Efficacy and acceptability of pharmacological, psychosocial, and brain stimulation interventions in children and adolescents with mental disorders: an umbrella review

Correll, Christoph U.; Cortese, Samuele; Croatto, Giovanni; Monaco, Francesco; Krinitski, Damir; Arrondo, Gonzalo; Ostinelli, Edoardo G; Zangani, Caroline; Fornaro, Michele; Estradé, Andrés; Fusar‐Poli, Paolo; Carvalho, André F.; Solmi, Marco

doi:10.1002/wps.20881

Cited by 93 publications

(68 citation statements)

References 126 publications

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“…waitlist) for controlling the therapeutic effect of nonspecific variables (33) . As a recent umbrella review has reported (36) , the effectiveness of psychotherapeutic interventions often decreases, at times becoming nonsignificant, when comparing them against control conditions with an active component.…”

Section: Strengths Of Our Meta-analysis and Systematic Reviewmentioning

confidence: 99%

Efficacy of Meaning-Centered Psychotherapy in adult patients with advanced cancer: A systematic review and meta-analysis

Dietrich¹,

Estradé²,

Cruzado³

2021

Psicooncología

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Objective: We conducted a PRISMA-compliant systematic review of clinical trials, and a meta-analysis of randomised clinical trials (RCTs) of manualised Meaning-Centered Psychotherapy (MCP) interventions for adult advanced cancer patients. We searched seven databases for trials published in English and Spanish, until March 27, 2021. Results: Seven trials were included in the systematic review, and four in the meta-analysis. The systematic review favoured the effectiveness of MCP for the improvement of spiritual well-being, quality of life (QoL), sense of meaning and psychological distress, although inconsistencies between the trials were found. In pre-post meta-analytic estimates, MCP had a superior therapeutic effect than control conditions for spiritual well-being (d=0.52, p<0.001), QoL (d=0.60, p<0.001), anxiety symptoms (d=-0.47, p<0.001), depressive symptoms (d=-0.50, p<0.001) and desire for hastened death (d=-0.28, p<0.001). No differences were observed in between-group comparisons. MCP was not associated with an increased risk of abandonment at post-treatment (OR=0.86, p=0.57). Conclusion: Manualised MCP interventions are a promising treatment for the improvement of spiritual well-being and quality of life and the reduction of psychological distress in adult patients with advanced cancer. The evidence base is still in an emerging state and should be expanded by higher methodological quality studies.

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Section: Strengths Of Our Meta-analysis and Systematic Reviewmentioning

confidence: 99%

Efficacy of Meaning-Centered Psychotherapy in adult patients with advanced cancer: A systematic review and meta-analysis

Dietrich¹,

Estradé²,

Cruzado³

2021

Psicooncología

Self Cite

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“…Youth mental health has received growing attention in recent years, as evidenced by the inclusion of 104 network meta-analyses and meta-analyses of randomised controlled trials (RCTs) on mental health interventions for children and adolescents in a recent umbrella review published in 2021. 15 However, there is limited synthesised evidence on interventions and types of support available for children with hearing loss that promote psychological, emotional and behavioural well-being, prevent mental health conditions and treat conditions that do arise. In 2019, a systematic review on the assessment and treatment of behavioural disorders in children with hearing loss found limited evidence of interventions to address behavioural problems.…”

Section: Introductionmentioning

confidence: 99%

Mental health support for children and adolescents with hearing loss: scoping review

et al. 2021

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Background Children with hearing loss are at increased risk of mental health conditions, including behavioural problems, but there is limited evidence about available mental health support. Aims We aimed to map the evidence on mental health support for children and adolescents with hearing loss. Method Medline, Embase, PsycINFO and grey literature databases were searched until April 2021. Articles of any study design were eligible if they described an intervention supporting the mental health of children with hearing loss. No restrictions were placed on geography or publication date. Four reviewers independently screened results by title, abstract and full text. Study characteristics and outcome data were extracted, with results narratively synthesised. Results From 5629 search results, 27 articles were included. A large majority of the studies (81%, n = 22) were from high-income settings, with two-thirds (67%, n = 18) conducted in the USA. Less than half (41%, n = 11) of the articles adopted experimental research designs, and the majority of studies included small samples. The interventions presented were diverse, with the majority either therapy based (30%, n = 8) or skills training (30%, n = 8). Interventions included ice-skating, parent–child interaction therapy and resilience training. When measured, interventions demonstrated at least some evidence of effectiveness, although this was not always assessed with gold-standard methodology. Conclusions The evidence is lacking in breadth, study quality and geographical spread. That said, what is available indicates a range of effective approaches to support the mental health of children with hearing loss. Additional research is needed to improve the breadth of evidence on mental health support for this population.

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“…For instance, it should be taken into consideration that apathy symptoms may not necessarily affect the performance at cognitive tests during routine visits, but still impact brain health in the long term. Alternatively, given the extensive number of investigations using brain stimulation techniques to treat mood disorders [ 55 ], the regions investigated in the present and previous studies may be selected in trials aiming at preventing clinical apathy by means of brain stimulation technologies.…”

Section: Discussionmentioning

confidence: 99%

Prefrontal hyperactivation during dual-task walking related to apathy symptoms in older individuals

et al. 2022

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Increasing evidence associates apathy with worsening in cognitive performance and greater risk of dementia, in both clinical and healthy older populations. In older adults with neurocognitive disorders, apathy has also been related to specific fronto-subcortical structural abnormalities, thus differentiating apathy and major depressive disorder. Yet, the neural mechanisms associated with apathy in healthy older adults are still unclear. In the present study, we investigated the frontal cortical response during a dual-task walking paradigm in forty-one healthy older adults with and without apathy symptoms, controlling for depressive symptoms. The dual-task walking paradigm included a single cognitive task (2-back), a single motor task (walking), and a dual-task condition (2-back whilst walking). The cortical response was measured by means of functional Near-Infrared Spectroscopy (fNIRS). The results revealed that participants with apathy symptoms showed greater activation of subregions of the prefrontal cortex and of the premotor cortex compared to healthy controls during the single cognitive component of the dual-task paradigm, whilst cognitive performance was equivalent between groups. Moreover, increased cortical response during the cognitive task was associated with higher odds of exhibiting apathy symptoms, independently of depressive symptoms. These findings suggest that apathy may be related to differential brain activation patterns in healthy older individuals and are in line with previous evidence of the distinctiveness between apathy and depression. Future research may explore the long-term effects of apathy on the cortical response in healthy older adults.

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Efficacy and acceptability of pharmacological, psychosocial, and brain stimulation interventions in children and adolescents with mental disorders: an umbrella review

Cited by 93 publications

References 126 publications

Efficacy of Meaning-Centered Psychotherapy in adult patients with advanced cancer: A systematic review and meta-analysis

Efficacy of Meaning-Centered Psychotherapy in adult patients with advanced cancer: A systematic review and meta-analysis

Mental health support for children and adolescents with hearing loss: scoping review

Prefrontal hyperactivation during dual-task walking related to apathy symptoms in older individuals

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