Efficacy and acceptability of vitamin D supplements for depressed patients: A systematic review and meta-analysis of randomized controlled trials

Srifuengfung, Maytinee; Srifuengfung, Somporn; Pummangura, Chalermsri; Pattanaseri, Keerati; Oon-arom, Awirut; Srisurapanont, Manit

doi:10.1016/j.nut.2022.111968

Cited by 7 publications

(5 citation statements)

References 59 publications

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“…A previous clinical study has shown that cognitive function and the quality of social interaction are associated with physical functions assessed using a six-minute walking test in patients undergoing HD [37]. Previous reports have suggested that vitamin D supplementation improves depression in nonCKD adults [38,39]. An animal study has shown that depression-like behavior is attenuated by exercise and leucine intake [40].…”

Section: Discussionmentioning

confidence: 99%

The combined effect of leucine-enriched essential amino acid supplements and locomotion training on physical functions and quality of life in hemodialysis patients

Kitabayashi,

Yamamoto,

Katano

et al. 2024

Ren Replace Ther

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Background Locomotive syndrome (LS) is a condition of reduced mobility (locomotive organ impairment) that is associated with reduced quality of life (QOL) in patients undergoing hemodialysis (HD), and effective interventions for patients with LS undergoing HD are unclear. We conducted a clinical trial to assess the effects of exercise and oral nutritional supplementation (ONS) on QOL in this cohort. Methods This study was an open-label, randomized controlled trial. The participants were patients with LS undergoing HD. The intervention period was 3 months. The primary outcome was a change in the physical component summary (PCS) of QOL, and the secondary outcomes were changes in other QOL scores, physical function, body composition, and nutritional status assessed by using the geriatric nutritional risk index. Participants were divided into the locomotion training (LT) and LT + ONS groups. Both groups were instructed on LT that comprised one-leg standing and squats to be carried out four or more times per week. The ONS consisted of 3 g leucin-rich essential amino acids and 800 IU vitamin D per pack, and the participants in the LT + ONS group received one pack of the supplement per day. Results In total, 40 individuals undergoing HD were included in the study; 3 patients in the LT + ONS group were excluded from the analysis because of hospitalization and incomplete assessment. The median age was 73 years (interquartile range: 62–80 years), 23 participants were men (62%), and the duration of dialysis treatment was 6 years (interquartile range: 3–16 years). The change in PCS of the LT + ONS group did not differ from that in the LT group [LT + ONS: −1.6 (−5.3, 6.8) versus LT: −0.1 (−5.3, 6.2), p = 0.94]. In contrast, the LT + ONS group showed maintenance in mental health (MH) and improvement of the two-step value. Conclusions The LT + ONS group did not show an effect on PCS in QOL compared with only LT in patients with LS undergoing HD. However, maintenance of MH and improvement of two-step value were confirmed in the LT + ONS group. Future research is need to confirm whether leucine-rich essential amino acids and vitamin D help mental health and physical function in patients with LS undergoing HD with larger sample sizes and long-term interventions. Clinical trial registration University Hospital Medical Information Network Center (UMIN 000032457).

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Section: Discussionmentioning

confidence: 99%

The combined effect of leucine-enriched essential amino acid supplements and locomotion training on physical functions and quality of life in hemodialysis patients

Kitabayashi,

Yamamoto,

Katano

et al. 2024

Ren Replace Ther

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“…A maternal serum vitamin D level of more than 30 nmol/L was associated with lower odds of offspring with ASD [235]. Two reviews suggested that vitamin D supplementation is useful in MDD, especially in adults and in patients with a severe degree of depressive symptoms [236,237]. To our knowledge, there are no systematic reviews or meta-analyses about vitamin D supplementation in personality disorders.…”

Section: Reviews and Meta-analysismentioning

confidence: 99%

Nutraceuticals in Psychiatric Disorders: A Systematic Review

Bozzatello,

Novelli,

Montemagni

et al. 2024

IJMS

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Correct nutrition and diet are directly correlated with mental health, functions of the immune system, and gut microbiota composition. Diets with a high content of some nutrients, such as fibers, phytochemicals, and short-chain fatty acids (omega-3 fatty acids), seem to have an anti-inflammatory and protective action on the nervous system. Among nutraceuticals, supplementation of probiotics and omega-3 fatty acids plays a role in improving symptoms of several mental disorders. In this review, we collect data on the efficacy of nutraceuticals in patients with schizophrenia, autism spectrum disorders, major depression, bipolar disorder, and personality disorders. This narrative review aims to provide an overview of recent evidence obtained on this topic, pointing out the direction for future research.

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“…This umbrella meta-analysis demonstrated a significant reduction in depressive symptoms in patients with vitamin D supplements and increased odds of depression in patients with low serum vitamin D levels. In another recent meta-analysis of 18 RCTs, vitamin D supplements were effective in depressed patients in heterogeneous data [ 77 ]. In these two recent meta-analyses, there were subgroup analyses of several factors that might modulate vitamin D efficacy, and no differences in the efficacy of vitamin D supplementation according to gender were observed, suggesting that vitamin D supplementation is beneficial to both men and women [ 76 , 77 ].…”

Section: The Association Of Vitamin D and Depressionmentioning

confidence: 99%

“…In another recent meta-analysis of 18 RCTs, vitamin D supplements were effective in depressed patients in heterogeneous data [ 77 ]. In these two recent meta-analyses, there were subgroup analyses of several factors that might modulate vitamin D efficacy, and no differences in the efficacy of vitamin D supplementation according to gender were observed, suggesting that vitamin D supplementation is beneficial to both men and women [ 76 , 77 ]. To date, there is growing promise that low vitamin D levels are related to the risk of depression and that vitamin D supplementation may be effective in treating depression.…”

Section: The Association Of Vitamin D and Depressionmentioning

confidence: 99%

The Associations of Vitamin D with Ovarian Reserve Markers and Depression: A Narrative Literature Review

Jeon

2023

Nutrients

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Since the identification of vitamin D receptors in both the female reproductive tract and the central nervous system, further data have shown that vitamin D is involved in the processes of reproductive and mental health. This paper reviews current research on the associations of vitamin D with ovarian reserve markers and depression and discusses the potential role of vitamin D in their relationships. There have been numerous studies reporting that vitamin D was significantly related to ovarian reserve markers and depression in basic or clinical research, but some observational and interventional clinical studies have shown inconsistent results. Nevertheless, recent meta-analyses of interventional studies have provided promising results showing that vitamin D supplementation significantly improves ovarian reserve metrics, especially in a subgroup of women with normal or diminished ovarian reserve, and decreases depressive symptoms and risk. The demonstration of an association of vitamin D with both ovarian reserve and depression could suggest that vitamin D may be another important key in explaining female reproductive depression. Larger-scale studies in standardized settings will be needed in order to gain further insight into the role of vitamin D in female reproduction and depression.

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Efficacy and acceptability of vitamin D supplements for depressed patients: A systematic review and meta-analysis of randomized controlled trials

Cited by 7 publications

References 59 publications

The combined effect of leucine-enriched essential amino acid supplements and locomotion training on physical functions and quality of life in hemodialysis patients

The combined effect of leucine-enriched essential amino acid supplements and locomotion training on physical functions and quality of life in hemodialysis patients

Nutraceuticals in Psychiatric Disorders: A Systematic Review

The Associations of Vitamin D with Ovarian Reserve Markers and Depression: A Narrative Literature Review

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