Efficacy and adverse reaction management of oncolytic viral intervention combined with chemotherapy in patients with liver metastasis of gastrointestinal malignancy

Abstract

BackgroundThe liver is a key target organ for colorectal and gastric cancer metastasis. One of the challenges in the treatment of colorectal and gastric cancers is the management of liver metastasis. This study aimed to investigate the efficacy, adverse effects, and coping strategies of oncolytic virus injection in patients with liver metastases of gastrointestinal malignancies.MethodsWe prospectively analyzed patients treated at Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine from June 2021 to October 2022. 47 patients with gastrointestinal cancer liver metastasis were included in the study. The data, including clinical manifestations, imaging, tumor markers, postoperative adverse reactions, psychological intervention, dietary guidance, and adverse reaction management were evaluated.ResultsOncolytic virus injection was successful in all patients, and no drug injection-related deaths occurred. The adverse effects, such as fever, pain, bone marrow suppression, nausea, and vomiting, were mild and resolved subsequently. Based on the comprehensive intervention of nursing procedures, the postoperative adverse reactions of patients were effectively alleviated and treated. None of the 47 patients had any puncture point infections, and the pain caused by the invasive operation was relieved quickly. After 2 courses of oncolytic virus injection, postoperative liver MRI showed 5 partial remissions, 30 stable diseases, and 12 progressive diseases in target organs.ConclusionInterventions based on nursing procedures can ensure the smooth treatment of recombinant human adenovirus type 5 in patients with liver metastases of gastrointestinal malignant tumors. This is of great importance for clinical treatment and significantly reduces patient complications and improves the patient’s quality of life.

A Review of CAR-T Combination Therapies for Treatment of Gynecological Cancers

“…Standard immunotherapy techniques and checkpoint inhibitors may cause immune-related and systemic toxicity, as well as various levels of chemotherapy drug resistance. However, studies on the novel oncolytic viral therapy report less overall systemic side effects, most of which can be managed with standard hospital care [ 56 ]. Therefore it is possible to suggest that the use of oncolytic viral therapy in conjunction with CAR-T can potentially be a more effective option for the treatment of solid tumors.…”

Effect of skinfold thickness on arm venous access port in cancer patients

“… 1 , 2 , 3 Although immunotherapy has provided new opportunities for the treatment of cancer patients in recent years, surgical resection supplemented by chemoradiotherapy is currently mainly used in the clinical treatment of cancer, and chemotherapeutic drugs have greater vascular damage and long‐term frequent intravenous infusion stimulates blood vessels, which can easily cause complications such as phlebitis. 4 , 5 Port is an intravenous infusion device implanted subcutaneously for long‐term indwelling, which can be repeatedly punctured for 2000 times and is suitable for long‐term application in cancer patients. It can effectively reduce the pain caused by repeated puncture of peripheral veins in patients.…”