Efficacy and immunological changes of sublingual immunotherapy in pediatric allergic rhinitis

Zeng, Yinhui; Xiao, Haiqing; Gao, Shengli; Li, Jinyuan; Liu, Yang; Zeng, Qingxiang; Luo, Xiaodong; Luo, Renzhong; Chen, Xi; Liu, Wenlong

doi:10.1016/j.waojou.2023.100803

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…Our results further substantiated the previous findings that the longer duration of SLIT treatment contributing the better efficacy (29,30). Also, our findings manifested that SLIT performed a significant efficacy on AR patients.…”

Section: Discussionsupporting

confidence: 91%

Clinical efficacy and safety evaluation of Dermatophagoides farinae drops in the treatment of allergic rhinitis with epistaxis

Pei,

Ding,

Cai

et al. 2024

Eur Ann Allergy Clin Immunol

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Background. Epistaxis is frequently observed in allergic rhinitis (AR) patients. However, few studies focus on the outcome of epistaxis with treatment of AR patients. This study aimed to retrospectively analyze the efficacy and safety of AR patients with epistaxis treated with sublingual immunotherapy (SLIT). Methods. A total of 74 patients aged 4-60 years with house dust mite (HDM)-induced AR accompanied by epistaxis and who completed 1 year of SLIT treatment with standard Dermatophagoides farinae (D. farinae) drops were enrolled in this study. The symptom scores, total medication scores (TMS), combined symptom and medication score (CSMS), visual analog scales (VAS), and bleeding score (BS) were assessed, as well as the nasal endoscopic examinations were performed to observe nasal signs. Results. The levels of symptom scores, TMS, CSMS, VAS, and BS at 0.5 year and 1 year of SLIT treatment were significantly lower than those at the baseline (all p < 0.01). Also, statistical differences were seen in CSMS (p < 0.05) and VAS (p < 0.01) between 0.5 year and 1 year. As expected, BS was M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o n positively correlated with CSMS (r = 0.617, 95% CI 0.517-0.699) and VAS (r = 0.777, 95% CI 0.719-0.822) at all three time points. Conclusions. SLIT with D. farinae drops was effective and safe for AR patients with epistaxis, resulting in improving the symptoms of rhinitis while relieving the symptoms of epistaxis.

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Section: Discussionsupporting

confidence: 91%