Efficacy and outcome of extensive intraoperative peritoneal lavage plus surgery <i>vs </i>surgery alone with advanced gastric cancer patients

Song, En-Dong; Xia, Heng-Bo; Zhang, Lixiang; Ma, Jun; Luo, Pei; Yang, Lai-Zhi; Xiang, Ben-Hong; Zhou, Baichuan; Chen, Lei; Sheng, Hui; Yin, Fang‐Fang; Han, Wenxiu; Wei, Zhijian; Xu, Aman

doi:10.4240/wjgs.v15.i3.430

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…However, they found that addition of EIPL with saline did not improve the 3-year survival rate of advanced gastric cancer patients compared with surgery alone[ 3 ]. A latest randomized study evaluated the efficacy and long-term outcome of advanced gastric cancer patients with EIPL[ 4 ]. It was found that EIPL can reduce the possibility of perioperative complications including ileus and abdominal abscess.…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy

Yao,

Yuan,

Zhang

et al. 2023

World J Gastrointest Surg

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Postcholecystectomy bile duct injury (BDI) remains a devastating iatrogenic complication that adversely impacts the quality of life with high healthcare costs. Despite a decrease in the incidence of laparoscopic cholecystectomy-related BDI, the absolute number remains high as cholecystectomy is a commonly performed surgical procedure. Open Roux-en-Y hepaticojejunostomy with meticulous surgical technique remains the gold standard surgical procedure with excellent long-term results in most patients. As with many hepatobiliary disorders, a minimally invasive approach has been recently explored to minimize access-related complications and improve postoperative recovery. Since patients with gallstone disease are often admitted for a minimally invasive cholecystectomy, laparoscopic and robotic approaches for repairing postcholecystectomy biliary stricture are attractive. While recent series have shown the feasibility and safety of minimally invasive post-cholecystectomy biliary stricture management, most are retrospective analyses with small sample sizes. Also, long-term follow-up is available only in a limited number of studies. The principles and technique of minimally invasive repair resemble open repair except for the extent of adhesiolysis and the suturing technique with continuous sutures commonly used in minimally invasive approaches. The robotic approach overcomes key limitations of laparoscopic surgery and has the potential to become the preferred minimally invasive approach for the repair of postcholecystectomy biliary stricture. Despite increasing use, lack of prospective studies and selection bias with available evidence precludes definitive conclusions regarding minimally invasive surgery for managing postcholecystectomy biliary stricture. High-volume prospective studies are required to confirm the initial promising outcomes with minimally invasive surgery.

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Section: Introductionmentioning

confidence: 99%

Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy

Yao,

Yuan,

Zhang

et al. 2023

World J Gastrointest Surg

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Efficacy and Safety of Extensive Intraperitoneal Lavage for Patients with Gastric Cancer — A Systematic Review and Meta-analysis

Najah,

Abdelrehim,

Elmallahy

et al. 2023

J Gastrointest Canc

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Extensive intraoperative peritoneal lavage with surgery, compared to surgery alone, for patients diagnosed with gastric cancer: a systematic review and meta-analysis of randomized controlled trials

Adil,

Ghori,

Anwar

et al. 2024

International Journal of Surgery

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Background: Gastric cancer ranks as the fifth most frequently diagnosed cancer and the seventh most prevalent overall. The lifetime risk of developing gastric cancer is 1.87% for males and 0.79% for females worldwide. Aim: This systematic review and meta-analysis aimed to determine whether Extensive Intraoperative Peritoneal Lavage (EIPL) provides short-term benefits or improved survival outcomes for patients undergoing gastrectomy. Methods: A comprehensive search spanned PubMed, Embase, Cochrane Library, clinicaltrials.gov, and Web of Science, from their inception up to October 2023, adhering to predefined inclusion and exclusion criteria. The quality of the studies was analyzed using the Cochrane Collaboration Risk of Bias Tool. Data analysis was done using Review Manager 5.3, utilizing a random-effects model. Results: Our analysis incorporated seven randomized controlled trials with 2602 patients. The follow-up time for all outcomes varied from 30-60 months. For our primary outcomes, EIPL demonstrated a significant benefit over surgery alone in terms of recurrence (RR=0.73; 95% CI: 0.65 to 0.83, P<0.00001) and postoperative complications (RR=0.67; 95% CI: 0.51 to 0.87, P=0.003). For our secondary outcomes, postoperative hospital stay (MD=-0.35; 95% CI: −1.11 to 0.41; P-value=0.37), 3-year overall survival (OR=1.44; 95% CI 0.84 to 2.47; P-value=0.19), 3-year disease-free survival (HR=0.93; 95% CI: 0.78 to 1.13; P-value=0.48), and time to first flatus (MD=-0.17; 95% CI: −0.35 to 0.01; P-value=0.06), no statistically significant differences were observed between the EIPL and control groups. Conclusion: While there is a marginal difference in survival outcomes, EIPL holds promise in significantly reducing overall cancer recurrence and suggests an enhancement in postoperative recovery.

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Efficacy and outcome of extensive intraoperative peritoneal lavage plus surgery vs surgery alone with advanced gastric cancer patients

Cited by 3 publications

References 22 publications

Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy

Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy

Efficacy and Safety of Extensive Intraperitoneal Lavage for Patients with Gastric Cancer — A Systematic Review and Meta-analysis

Extensive intraoperative peritoneal lavage with surgery, compared to surgery alone, for patients diagnosed with gastric cancer: a systematic review and meta-analysis of randomized controlled trials

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