Efficacy and Patient Acceptance of Pilocarpine Gel

Goldberg, Ivan; Ashburn, Frank S.; Kass, Michael A.; Becker, Bernard

doi:10.1016/0002-9394(79)90561-0

Cited by 37 publications

(10 citation statements)

References 7 publications

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“…They stressed that diurnal monitoring was necessary [9]. Goldberg and associates compared pilocarpine gel at bedtime in one eye with 4% pilocarpine eye drops four times daily in the fellow eye of 15 patients for a 30-day period and found the effects to be similar for 17 hours after gel administration, but found no reduction in intraocular pressure 23 hours after gel administration [3].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of the combination therapy Pilogel®/β-blocker: Interim results

Maas

et al. 1989

Doc Ophthalmol

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The interim results of a multicentered clinical trial with the combination therapy therapy Pilogel/topical beta-blocker (twice daily) in patients with primary open angle glaucoma or ocular hypertension are discussed. Six patients were treated with Pilogel and a topical beta-blocker for one month. Four out of six patients responded well to the combination therapy. Most patients experienced some difficulty in applying the gel and their eyelids stuck together on awakening. In two patients a superficial punctate keratitis was observed. We found an average decrease in intra-ocular pressure (IOP) of 22.5% 22.5 hours after Pilogel administration, but there was some tendency towards higher evening values compared to morning values. In view of the appearance of a corneal haze as described by Johnson et al. during long-term treatment, longer follow-up is necessary.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of the combination therapy Pilogel®/β-blocker: Interim results

Maas

et al. 1989

Doc Ophthalmol

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“…Table 6 4 showed that pilocarpine in gel once a day improved patient compliance. Pilocarpine in oil used twice a day reduced the mean intraocular pressure more than aqueous pilocarpine 4 times a day.…”

Section: Resultsmentioning

confidence: 99%

“…On the second day of admission a controlled phasing was done 4 times a day with a Goldmann applanation tonometer. On the third day of admission the tensions were taken in a similar manner, with 9 eyes receiving aqueous pilocarpine drops 4 times a day and 10 eyes receiving oily pilocarpine drops twice a day.…”

Section: Methodsmentioning

confidence: 99%

Comparative study of aqueous and oily pilocarpine in the production of ocular hypotension.

Bhojwani¹,

Jones²

1981

British Journal of Ophthalmology

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The patients were admitted to hospital, and the aqueous pilocarpine drops were discontinued for 24 hours. All other antiglaucomatous medications, if prescribed, were unaltered throughout the trial.On the second day of admission a controlled phasing was done 4 times a day with a Goldmann applanation tonometer. On the third day of admission the tensions were taken in a similar manner, with 9 eyes receiving aqueous pilocarpine drops 4 times a day and 10 eyes receiving oily pilocarpine drops twice a day. The percentage concentration of aqueous and oily pilocarpine was the same as the patient had been taking before the trial. Topical application of pilocarpine was withheld on the third day and the intraocular pressures were not recorded. On the final day the tensions were recorded with 9 patients receiving oily pilocarpine drops and 10 patients receiving the aqueous form.The intraocular tensions were measured on the same tonometer by the same examiner, and the mean of 3 readings was taken. The examiner was unaware of the type of pilocarpine instilled, and the patients were asked to note any difference in the 'first' and 'second' medications. Results

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“…One of these systems, described as a high viscosity acrylic vehicle, delivers a 24-hr pilocarpine dose from a single, nighttime placement in the cul-de-sac [Goldberg et al, 1979;Mandell et al, 1979;March et al, 19821. As is usual with hydrophilic matrices, the effect is greatest immediately after instillation and diminishes with time [Goldberg et al, 19791.…”

Section: Soluble Gelsmentioning

confidence: 99%

Ophthalmic drug delivery systems

Shell

1985

Drug Development Research

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Shell, J.W.: Ophthalmic drug delivery systems. Drug Dev. Res. 6:245-261, 1985. New ophthalmic drug delivery systems are currently receiving increased attention, in part because of the expected emergence of new drugs with short biological half-lives whose usefulness may depend on a more continuous drug supply than eyedrops can provide, but also because of the potential of some delivery systems to reduce the side effects of the more potent drugs recently introduced or presently under investigation. Some ophthalmic delivery systems extend the duration of drug action by enhancement of corneal absorption; these systems include soluble gels and emulsions, hydrophilic ocular inserts, ion-pair associations, prodrugs, and liposomes. Since these systems enhance the "pulse entry" of the drug, they are limited to use with drugs whose dose-related side effects are not serious. Other delivery systems provide for a controlled release of drugs and therefore minimize the pulse entry with which side effects are associated. They can be based on any of several different mechanisms and include both erodible and nonerodible matrices. The various delivery systems that have recently been developed and those that are currently known to be under investigation are described in this paper, along with some observations regarding the future outlook of ophthalmic drug delivery systems.

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Efficacy and Patient Acceptance of Pilocarpine Gel

Cited by 37 publications

References 7 publications

Efficacy and safety of the combination therapy Pilogel®/β-blocker: Interim results

Efficacy and safety of the combination therapy Pilogel®/β-blocker: Interim results

Comparative study of aqueous and oily pilocarpine in the production of ocular hypotension.

Ophthalmic drug delivery systems

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