2024
DOI: 10.2174/0113894501275292231220062838
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Efficacy and Possible Mechanisms of Astragali Radix and its Ingredients in Animal Models of Osteoporosis: A Preclinical Review and Metaanalysis

Ning Cao,
Zhangxuan Shou,
Yi Xiao
et al.

Abstract: Background: Astragali Radix (AR) has a long history as a traditional Chinese medicine for anti-osteoporosis (OP) treatment. The aim of the study was to explore the effect and optimal regimens of AR and its main ingredients (IAR) in OP treatment. Methods: Eligible animal studies were searched in seven databases (PubMed, Web of Science, MEDLINE, SciELO Citation Index, Cochrane Library, China National Knowledge Infrastructure and Wanfang). The primary outcomes were bone metabolic indices. The secondary outcome … Show more

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“… 8 Astragalus membranaceous (AM) is a common food‐origin Chinese medicine with a long history of treating osteoporosis, inflammation and other related diseases. 9 Calycosin (CA) is the main active compound of AM, a plant oestrogen with various pharmacological properties such as anti‐inflammatory, anti‐osteoporotic and antioxidant activities, 10 implying that it may have an inhibitory effect on inflammatory‐related osteolysis diseases such as PPO. But to the best of our knowledge, the therapeutic effect of CA on PPO, especially its role in Ti particle‐induced macrophage polarization and subsequent osteogenesis promotion, remains elusive.…”
Section: Introductionmentioning
confidence: 99%
“… 8 Astragalus membranaceous (AM) is a common food‐origin Chinese medicine with a long history of treating osteoporosis, inflammation and other related diseases. 9 Calycosin (CA) is the main active compound of AM, a plant oestrogen with various pharmacological properties such as anti‐inflammatory, anti‐osteoporotic and antioxidant activities, 10 implying that it may have an inhibitory effect on inflammatory‐related osteolysis diseases such as PPO. But to the best of our knowledge, the therapeutic effect of CA on PPO, especially its role in Ti particle‐induced macrophage polarization and subsequent osteogenesis promotion, remains elusive.…”
Section: Introductionmentioning
confidence: 99%