2008
DOI: 10.1016/j.ejpn.2007.09.003
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Efficacy and prognosis of a short course of prednisolone therapy for pediatric epilepsy

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Cited by 38 publications
(36 citation statements)
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“…The most effective prednisolone regimen for Duchenne patients appears to be 0.75 mg/kg/day in a daily administration, which is comparable to the dosage used in this study. 35,36 Our results (43% good response) compare unfavourably with results of You et al 27 (79% good response) and Sinclair et al 18 (81% good response). The lower effectiveness of our treatment regimen may not only be due to the relatively low maintenance dosage of prednisolone, but also because the nature of the studied population.…”
Section: Discussionsupporting
confidence: 63%
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“…The most effective prednisolone regimen for Duchenne patients appears to be 0.75 mg/kg/day in a daily administration, which is comparable to the dosage used in this study. 35,36 Our results (43% good response) compare unfavourably with results of You et al 27 (79% good response) and Sinclair et al 18 (81% good response). The lower effectiveness of our treatment regimen may not only be due to the relatively low maintenance dosage of prednisolone, but also because the nature of the studied population.…”
Section: Discussionsupporting
confidence: 63%
“…Other reported side effects are irritability, Cushing syndrome, hyperglycaemia, hypokalaemia, higher risk for infections, and dilatation of ventricular and subarachnoid spaces. 18,26,27 Serious adverse events like infections and sepsis and cardiomyopathy predominantly occurred with the use of ACTH. 1,32e34 The longterm use of corticosteroids in Duchenne patients commonly had adverse effects, although clinically mild.…”
Section: Discussionmentioning
confidence: 99%
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“…Lichtenfeld et al (2010) reported a significant reduction in EEG abnormalities in a girl presenting with absence seizures treated with a pulse therapy regimen. Although literature reports have indicated a high relapse rate in patients with epileptic encephalopathy (44-70% within 3-6 months) (Sinclair, 2003;Gupta and Appleton, 2005;Verhelst et al, 2005;Okumura et al, 2006;You et al, 2008), this was not confirmed by the present study. There are several theories regarding the mechanism of action of corticosteroids in epilepsy.…”
Section: Discussioncontrasting
confidence: 57%