Efficacy and Safety Analysis of Multislice Spiral CT-Guided Transthoracic Lung Biopsy in the Diagnosis of Pulmonary Nodules of Different Sizes

Abstract

Objective. This study is aimed at investigating the efficacy and safety of multislice spiral CT-guided transthoracic lung biopsy in the diagnosis of pulmonary nodules of different sizes. Methods. Data of 78 patients with pulmonary nodules who underwent CT-guided transthoracic lung biopsy in our hospital from January 2020 to December 2021 were retrospectively analyzed, and they were divided into the small nodules group ( n = 12 ), medium nodules group ( n = 35 ), and large nodules group ( n = 31 ) according to the diameter of pulmonary nodules. The results of puncture biopsy and final diagnosis of pulmonary nodules of different sizes were compared. The incidence of complications in patients with pulmonary nodules of different sizes was compared. Univariate analysis was used to compare the incidence of complications in 78 patients. Logistic multiple regression analysis was used to analyze the independent risk factors of pneumothorax in patients with pulmonary nodule puncture. Logistic multiple regression analysis was used to analyze the independent risk factors of pulmonary hemorrhage in patients with pulmonary nodule puncture. Results. The diagnostic accuracy, sensitivity, and specificity were 83.33%, 100.00%, and 77.78% in small nodules group. The diagnostic accuracy, sensitivity, and specificity of medium nodules group were 85.71%, 100.00%, and 73.68%, respectively. The diagnostic accuracy, sensitivity, and specificity of large nodules group were 93.55%, 100.00%, and 33.33%, respectively. There was no significant difference in the incidence of pneumothorax among the three groups ( P > 0.05 ). The incidence of pulmonary hemorrhage in small nodule group was higher than that in the medium nodule group and large nodule group, and the difference was statistically significant ( P < 0.05 ). There was no significant difference in the incidence of total complications among the three groups ( P > 0.05 ). There were statistically significant differences in clinical data such as the needle tract length, the puncture position, and the distance of the puncture needle passing through the lung tissue in patients with or without pneumothorax ( P < 0.05 ). There were statistically significant differences in needle tract length, distance of puncture needle passing through lung tissue, and size of pulmonary nodules in patients with or without pulmonary hemorrhage ( P > 0.05 ). Logistic multivariate analysis showed that needle tract length ≤ 50 mm , lateral decubitus position, and the distance of puncture needle passing through lung tissue ≥ 14 mm were independent risk factors for pneumothorax after puncture in patients with pulmonary nodules ( P < 0.05 ). The needle tract length > 50 mm , the distance of puncture needle passing through lung tissue ≥ 14 mm , and small nodules (pulmonary nodules diameter ≤ 10 mm ) were independent risk factors for pulmonary hemorrhage after puncture in patients with pulmonary nodules ( P < 0.05 ). Conclusion. Multislice spiral CT-guided transthoracic lung biopsy is effective in diagnosing pulmonary nodules of different sizes.

Accuracy Study on Deep Learning-Based CT Image Analysis for Lung Nodule Detection and Classification

“…Theoretically, each channel has l energy functions. Let ωu=1/l-1Σ l-1 x=1ax, δ 2 u=1/l-1Σ l-1 x=1(ax-ωu) 2 , where:…”

“…In the past few decades, with the rapid development of computer vision and medical imaging technologies, deep learning-based analysis of CT images has shown tremendous potential in the detection and classification of lung nodules [1][2][3][4]. Lung nodules are one of the earliest signs of lung cancer, which is one of the most lethal cancers worldwide.…”

Eficacia diagnóstica de la Biopsia dirigida por TAC en la detección de masas pulmonares

“…Existen varias limitaciones, cuando el procedimiento es guiado por ultrasonido; la principal es cuando las lesiones no son periféricas, y no se encuentran en contacto con la superficie pleural, o cuando el tamaño de la lesión es menor a 10mm, existirá alto riesgo de falla diagnóstica; además existe el riesgo de realizar varias punciones, siendo factor directo para aparición de complicaciones, esto lo comprueba Ma L. et al, en su estudio donde se realizó 83 biopsias guiadas por ultrasonido con una precisión diagnostica del 76,6%, el bajo porcentaje se debe a la distancia 1.91 ± 1.51 de la lesión o masa con la superficie pleural, sin embargo a diferencia de la TAC se puede detectar complicaciones en tiempo real, y no existirá radiaciones ionizantes (33,34,35). (36,38,39).…”

Diagnosis of Malignant Pulmonary Nodules Using a Combination of Tumor-associated Autoantibodies and Computed Tomography

“…Early LC often manifests as pulmonary nodules, which are lesions with a diameter of ≤30 mm in the lungs. According to computed tomography (CT) imaging morphology, pulmonary nodules can be classified as solid nodules, partially solid nodules, or ground-glass nodules 3 . Imaging examinations such as x-ray, low-dose spiral CT, and enhanced CT have always been some of the most important methods for LC examination.…”

“…According to computed tomography (CT) imaging morphology, pulmonary nodules can be classified as solid nodules, partially solid nodules, or ground-glass nodules. 3 Imaging examinations such as x-ray, low-dose spiral CT, and enhanced CT have always been some of the most important methods for LC examination. The advantages of chest x-rays include the short examination time, convenient operation, low cost, and low radiation, but it is difficult to detect small lesions and display areas with x-rays.…”