Efficacy and safety evaluation of dexmedetomidine for postoperative patient controlled intravenous analgesia: A systematic review and meta-analysis

Chen, Rui; Sun, Shujun; Li, Yufan; Dou, Xiaoke; Dai, Maosha; Wu, Yan; Lin, Yun

doi:10.3389/fphar.2022.1028704

Cited by 4 publications

(1 citation statement)

References 62 publications

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“…Its adjunctive effects to anesthesia are well known and are used as fundamental component of multimodal analgesia. In addition to their analgesic effect, they have been shown to reduce the use of perioperative opioids [18,[42][43][44][45][46].…”

Section: Alpha-2 Agonistsmentioning

confidence: 99%

Postoperative Analgesia in Plastic Surgery Procedures

Arévalo-Villa,

Figueroa Morales,

de Jesús Jiménez-Contreras

et al. 2023

Topics in Postoperative Pain

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Advances in the knowledge of the secondary effects of acute postoperative pain have motivated anesthesiologists and surgeons to pay special attention to its prevention and correct management. Surgical procedures in plastic surgery are very varied and produce postoperative pain in direct relation to the site, type, and extent of surgery, with facial interventions being the least painful (with the exception of rhinoplasty) and the most painful being breast surgery, abdominoplasty, and extensive liposuctions due to the possibility of trauma to peripheral nerves and greater secondary inflammation. The combination of surgeries produces more intense post-surgical pain. There is insufficient data on the frequency and severity of pain after plastic surgery, be it reconstructive or cosmetic. Although opioids have been considered to be the cornerstone in the treatment of postsurgical pain, their use in plastic surgery patients must be carefully evaluated for various reasons that interfere with the results of this type of surgery. Similar to other surgical specialties, multimodal analgesia is now the most appropriate way to prevent and treat pain in these patients. This chapter is a comprehensive review of the management of acute postoperative pain in certain plastic surgery procedures, with emphasis on the multimodal approach.

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Section: Alpha-2 Agonistsmentioning

confidence: 99%

Postoperative Analgesia in Plastic Surgery Procedures

Arévalo-Villa,

Figueroa Morales,

de Jesús Jiménez-Contreras

et al. 2023

Topics in Postoperative Pain

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Advances in the use of dexmedetomidine during the perioperative period to improve postoperative sleep quality in patients undergoing surgery

Ji,

Su,

Gao

et al. 2024

J Int Med Res

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There is a high incidence of postoperative sleep and sleep architecture disorders in patients undergoing surgery, and dexmedetomidine (DEX) is commonly used to improve postoperative sleep quality and ameliorate the adverse effects of poor sleep on various organ systems. The continuous intraoperative intravenous infusion of DEX, the addition of DEX to postoperative intravenous analgesia pumps, and the continuous infusion of DEX after admission to the intensive care unit are often used clinically to improve postoperative sleep quality at doses of 0.1 to 0.7 μg/kg/hour, but the effects of DEX on sleep quality and structure identified in these studies have been inconsistent. Thus, it is unclear whether DEX improves postoperative sleep quality. The various methods of administering DEX to improve postoperative sleep quality have differing effects, the route used modifies the effect of DEX on sleep structure, and the intrinsic mechanism whereby DEX improves sleep quality remains to be fully investigated. In the present review, we describe new directions for future research into the effects of DEX on postoperative sleep quality and the mechanisms involved, which should help guide the design of further studies. This narrative review was completed according to the Scale for the Assessment of Narrative Review Articles (SANRA).

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Dexmedetomidine and surgical field visibility in nasal surgery: A systematic review and meta-analysis

Warner,

Munhall,

Nguyen

et al. 2024

Journal of Perioperative Practice

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Introduction: Nasal and sinus surgery, especially using endoscopy, relies upon adequate haemostasis to be safe and effective. Often other haemostatic methods, such as cautery are not viable, and other methods must be employed. This study examines the effectiveness of dexmedetomidine in controlled hypotension and for surgical field visibility in endoscopic sinus surgery and other nasal surgeries. Review Methods: A literature search was conducted in PubMed, Scopus, CINAHL and Central for randomised controlled trials using dexmedetomidine for controlled hypotension in adult patients undergoing endoscopic sinus surgery or other nasal surgery. Meta-analysis of mean differences and single means were performed. Results: Of 935 identified studies, 31 met the inclusion criteria. A statistically significant difference in Fromme–Boezaart surgical field visibility scores was found comparing dexmedetomidine to placebo (p < 0.00001) and propofol (p < 0.0001), but not other agents. A significant difference in intraoperative blood loss volume was found compared with placebo (51.5mL, p < 0.00001) and propofol (13.6mL, p < 0.0001), but not other agents. Conclusion: Dexmedetomidine demonstrated significantly improved surgical field visibility and blood loss volume compared with placebo and propofol, but not other agents. Dexmedetomidine is viable and useful for controlled hypotension in nasal surgery. Choice of controlled hypotension agent should follow patient and procedure-specific considerations.

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Efficacy and safety evaluation of dexmedetomidine for postoperative patient controlled intravenous analgesia: A systematic review and meta-analysis

Cited by 4 publications

References 62 publications

Postoperative Analgesia in Plastic Surgery Procedures

Postoperative Analgesia in Plastic Surgery Procedures

Advances in the use of dexmedetomidine during the perioperative period to improve postoperative sleep quality in patients undergoing surgery

Dexmedetomidine and surgical field visibility in nasal surgery: A systematic review and meta-analysis

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