Efficacy and safety of 13 surgical techniques for the treatment of complex anal fistula, non-Crohn CAF: a systematic review and network meta-analysis

An, Yongkang; Gao, Jihua; Xu, Jiancheng; Qi, Wenyue; Wang, Linyue; Tian, Maosheng

doi:10.1097/js9.0000000000000776

Cited by 6 publications

References 36 publications

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Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula

Wang,

Ma,

et al. 2024

Advanced Science

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Anal fistula is a common disease with recurrent inflammation and accumulated exudate. Traditional treatments often fail to effectively eliminate inflammation and ensure adequate drainage, leading to prolonged healing time and a high recurrence rate. Herein, a new class of quaternized molecular brush‐grafted injectable microgel (denoted as GAA@CNT‐g‐PVBTMA) is developed through thermal polymerization and mechanical fragmentation to promote the healing process of anal fistula. Benefiting from the fragmented morphology with a porous structure, the microgel can effectively fill the fistula and facilitate the drainage of exudate. Owing to the electrostatic interactions between the positively charged quaternized carbon nanotube molecular brush (CNT‐g‐PVBTMA) and the negatively charged inflammatory cytokines, GAA@CNT‐g‐PVBTMA microgel exhibits excellent anti‐inflammatory properties with scavenging rates of 92.6% for tumor necrosis factor‐α (TNF‐α) and 92.5% for interleukin‐1β (IL‐1β). Rat inflammatory anal fistula model demonstrates that the microgel can effectively reduce inflammation and epithelialization of the fistula, thereby promoting the healing of the anal fistula. By integrating effective filling, adequate drainage, and excellent anti‐inflammatory properties, GAA@CNT‐g‐PVBTMA microgel provides a promising new direction for the treatment of anal fistula.

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Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula

Wang,

Ma,

et al. 2024

Advanced Science

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Integrating multidisciplinary perspectives in complex anal fistula management: a blueprint for future research and precision surgery

Xu,

Mei,

Wang

2023

International Journal of Surgery

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Efficacy of anal duct ligation and muscle closure: A novel sphincter‐preserving surgical technique for fistula‐in‐ano

Kang,

Hyun,

Cho

et al. 2024

Colorectal Disease

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AimAlthough various sphincter‐preserving techniques exist for treating anal fistulas, none have demonstrated clear superiority. Therefore, the aim of this study was to introduce a novel sphincter‐preserving technique for anal duct ligation and muscle closure (ALMC) and analyse its perioperative outcomes.MethodThe data for patients who underwent ALMC for fistula‐in‐ano at Seoul Song Do Hospital between 2009 and 2023 were retrospectively reviewed. Patient demographics, intraoperative information and postoperative outcomes were assessed. The main outcomes were recurrence and wound healing. Recurrence was defined as the presence of a fistula tract or discharge more than 12 weeks after the primary surgery after achieving complete healing. Faecal incontinence was also investigated clinically.ResultsOverall, 556 patients (84.0% male; mean age 41.7 ± 12.3 years) underwent ALMC. Among these, 152 (27.3%) had a history of fistula surgery and 261 (46.9%) had suprasphincteric fistulas. Fistula‐in‐ano recurred in 33 patients (5.9%), wound healing was delayed in 97 (17.4%) and faecal incontinence was observed in 12 (2.2%). The mean follow‐up duration was 10.0 ± 16.0 months, and the average duration until recurrence was 13.8 ± 10.7 months. The proportion of suprasphincteric fistulas was similar in those who experienced recurrence and those who did not (57.6% vs. 46.3%, respectively; p = 0.239). The proportion of suprasphincteric fistulas in the delayed wound healing group was slightly higher, although the differences were not statistically significant (56.7% vs. 44.9%, respectively; p = 0.054).ConclusionALMC appeared to be a safe and feasible option for treating anal fistulas, providing good perioperative outcomes, particularly when sphincter preservation was crucial.

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Efficacy and safety of 13 surgical techniques for the treatment of complex anal fistula, non-Crohn CAF: a systematic review and network meta-analysis

Cited by 6 publications

References 36 publications

Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula

Quaternized Molecular Brush‐Grafted Injectable Microgel with Anti‐Inflammatory and Drainage Properties for Efficient Therapy of Anal Fistula

Integrating multidisciplinary perspectives in complex anal fistula management: a blueprint for future research and precision surgery

Efficacy of anal duct ligation and muscle closure: A novel sphincter‐preserving surgical technique for fistula‐in‐ano

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