Efficacy and safety of 5-aminolevulinic acid photodynamic therapy for the treatment of ulcerative squamous cell carcinoma

Dong, Liwen; Li, Xinying; Shen, Xiaoxiao; Zhang, Wanqi; Zhang, Junbo; Wang, Yuanyuan; Lu, Yuangang

doi:10.1016/j.pdpdt.2020.101710

Cited by 3 publications

(18 citation statements)

References 19 publications

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“…A variety of ALA concentrations were included in this systematic review. 20% ALA was used in 14 studies [16-18, 28, 29, 32, 33, 38, 39, 42, 44-47], with other concentrations being 10% [19,36,37,43], 5% [35,41], 4% [40], and 2% [31,48,49]. This result also accorded with our animal experiment groping basically.…”

Section: Photosensitizer Concentrationsupporting

confidence: 82%

“…Study characteristics were summarized in Table 1. A total of 25 papers consisted of 9 case reports [16,18,19,[31][32][33][34][35][36], 5 pilot study [17,29,[37][38][39], 3 case series [40][41][42], 5 randomized controlled trials[28, [43][44][45][46] and 3 prospective observational studies [47][48][49]. Across the 25 included articles, a total of 335 patients were enrolled in all studies, ranging in age from 15 to 93 years.…”

Section: Methodsmentioning

confidence: 99%

“…Data on this table showed that studies assessed the clinical application of ALA-PDT on different types of human skin wounds, including six studies of skin cancers [31,33,36,37,43,44], five studies of chronic leg ulcers[28, 29,31,39,46], three studies of erosive pustular skin diseases [16,38,42], and two studies of bilateral erosive oral lichen planus symptoms [40,41].…”

Section: Disease Profilementioning

confidence: 99%

“…were treated in studies reporting the sex of the subjects. The mean age of subjects was about In terms of population distribution of patients, skin cancers (105 patients) [31,33,36,37,43,44], leg and foot ulcers (62 patients) [28, 29,31,39,46] and anal fistula (59 patients) [48,49] were the most common diseases in the population, while carbuncle [32], chromosomiasis [18], leishmaniasis [34], hidradenitis suppurativa [35], and ulcerative necrobiosis lipoidica [19] were only a small subset with only one case in each study. CO2 laser injury (33 patients) [47], erosive oral lichen planus (22 patients) [40,41], Bowen's disease (BP) (18 patients) [45], erosive pustular dermatosis (14 patients) [16,38,42], furuncle and abscess (4 patients) [17], trauma (3 patients) [17] were moderate.…”

Section: Number Distribution Of Patientsmentioning

confidence: 99%

“…The ALA forms used in this systematic review varied by solutions, emulsions, creams, gels and ointments. ALA solutions were used in the majority of studies (14 studies, 182 subjects) [16,29,31,32,37,[42][43][44][45][46][47]49], followed by ALA gels (5 studies, 91 subjects) [33,34,[38][39][40][41]48], emulsions (2 studies, 17 subjects) [17,28], creams (3 studies, 3 subjects) [18,35,36], and ointments (1 study, 1 subject) [19]. This might be due to the superior homogeneity and cutaneous permeability of the solution compared to creams or gels [52].…”

Section: Photosensitizer Formulationmentioning

confidence: 99%

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5-Aminolevulinic Acid-Mediated Photodynamic Therapy on Wound Healing: A Systemic Review of Human Evidences

Huang,

Wang

2023

Journal of the American Podiatric Medical Association

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Backgrounds: Skin wounds are a kind of refractory disease frequently encountered in clinic, which brings enormous burden to patients. Great efforts to address the dilemma of wound healing have yielded some encouraging results, but they are still unsatisfactory. 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) has been developed as a promising noninvasive treatment for skin wounds. A systematic review was performed to determine the existing evidence base for the clinical use of ALA-PDT on refractory wounds. Methods: We conducted a PubMed search for English literature related to the clinical treatment of human skin ulcers by ALA-PDT published from 2012 to 2022, and performed a systematic review. Results: 25 studies were ultimately selected in the present review and summarized, including six studies of skin cancer, five studies of chronic leg ulcers, three studies of erosive pustular skin diseases, and two studies of erosive oral lichen planus symptoms. A total of 335 patients had approximately 355 ulcers, of which 315 ulcers received photodynamic therapy and 276 improved with ALA-PDT. 20% ALA solution, wavelength between 600 nm and 670 nm, energy density of 120 J/cm2, frequency of once per week and 3 sessions were the most selected therapeutic parameters. Generally, ALA-PDT for wounds was effective with main adverse events of mild to moderate pain, and follow-up was generally conducted within 1 year. Conclusions: This systematic review summarized the commonly used therapeutic parameters for ALA-PDT in the clinical treatment of skin wounds. After ALA-PDT alone or ALA-PDT combined with curettage, antibacterial and surgical treatment, all wounds healed well, and the adverse reactions were mainly mild to moderate pain, which could be relieved by cooling. ALA-PDT had proven to be a promising wound treatment modality through evidence of safety and efficacy.

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