Efficacy and Safety of a Glutaraldehyde-Modified House Dust Mite Extract in Allergic Rhinitis

Riechelmann, Herbert; Schmutzhard, Joachim; Werf, J. F. van der; Distler, A.; Kleinjans, H. A. J.

doi:10.2500/ajra.2010.24.3508

Cited by 57 publications

(54 citation statements)

References 20 publications

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“…Our clinical data are consistent with those obtained by other groups using the same treatment. In a prospective, randomized, double-blind clinical trial comparing the effects of 1 year of SIT with the same extract as we used in our study and placebo treatment, Riechelmann et al [26] showed that SIT performed better than control treatment in reducing symptoms and medication.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Efficacy of Immunotherapy with a Glutaraldehyde-Modified House Dust Mite Extract in Children by Monitoring Changes in Clinical Parameters and Inflammatory Markers in Exhaled Breath

Lozano¹,

Cruz²,

Piquer³

et al. 2014

Int Arch Allergy Immunol

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Introduction: The aim of this study was to evaluate the effectiveness of specific immunotherapy (SIT) management with allergoids in children with allergic asthma by monitoring changes in clinical parameters and inflammatory markers in exhaled breath. Methods: The study population included 43 patients (24 males) of 6-14 years of age, who had allergic asthma and were sensitized to mites. Twenty-three individuals were treated with subcutaneous SIT (PURETHALt Mites, HAL Allergy) for 8 months, i.e. the SIT group, and 20 were given medication to treat symptoms only, i.e. the control group. Before treatment and after 4 and 8 months, several clinical parameters, the levels of exhaled nitric oxide and the pH of exhaled breath condensate (EBC) were determined. Results: The SIT group presented with an improvement in asthma classification, a reduction in maintenance drug therapy and improved scores on the quality-of-life questionnaire. These changes were not observed in the control group. Both groups presented significant decreases in EBC pH values at 4 and 8 months after treatment compared to at baseline. However, analysis of the variable ‘ratio' showed an increase in the EBC pH values after 8 months of treatment in the SIT group compared with the values at 4 months. Conclusions: SIT with standardized mite extract reduces asthma symptoms in children. A decrease in EBC pH values was observed in both groups, although the SIT group presented a tendency of recovered values after 8 months. Future studies of EBC pH monitoring in the longer term are needed to determine the effectiveness of this marker. i 2014 S. Karger AG, Basel

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Section: Discussionmentioning

confidence: 99%

Assessing the Efficacy of Immunotherapy with a Glutaraldehyde-Modified House Dust Mite Extract in Children by Monitoring Changes in Clinical Parameters and Inflammatory Markers in Exhaled Breath

Lozano¹,

Cruz²,

Piquer³

et al. 2014

Int Arch Allergy Immunol

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“…[1][2][3] However, SCIT requires frequent office visits, which might be inconvenient for many patients. Indeed, inconvenience is the most common reason for a patient to discontinue or reject SCIT.…”

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confidence: 99%

Onset and dose-related efficacy of house dust mite sublingual immunotherapy tablets in an environmental exposure chamber

Nolte

Maloney

Nelson

et al. 2015

Journal of Allergy and Clinical Immunology

148

101

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“…The preseasonal schedule is generally performed in patients with pollinosis while the perennial schedule is preferentially used in mite-induced allergic rhinoconjunctivitis and/or asthma. Both preseasonal and perennial immunotherapy with allergoids have been shown to be effective in terms of clinical parameters, including rhinoconjunctivitis and/or asthma symptom and medication scores [10,11,12,13,14,15,16,17,18], conjunctival [10,12], nasal and skin reactivity [13,17,18] as well as the immunological parameters. Moderate reductions in allergen-specific IgE, remarkable increases in allergen-specific IgG1 and IgG4 [10,11,13] and a significant decline in IL-4 levels in allergen-stimulated peripheral blood mononuclear cell culture supernatant have been shown in several studies [13].…”

Section: Introductionmentioning

confidence: 99%

Desensitization Effect of Preseasonal Seven-Injection Allergoid Immunotherapy with Olive Pollen on Basophil Activation: The Efficacy of Olive Pollen-Specific Preseasonal Allergoid Immunotherapy on Basophils

Gökmen¹,

Ersoy²,

Gülbahar³

et al. 2012

Int Arch Allergy Immunol

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Background: It has previously been demonstrated that subcutaneous immunotherapy with allergoids positively affects clinical and immunological parameters even after 7 preseasonal injections. However, its effect on basophil activation remains unclear. We investigated the effect of preseasonal allergoid immunotherapy on basophils and concomitantly assessed its clinical and immunological efficacy in olive pollen-monosensitized patients. Methods: This study enrolled 437 consecutive patients with respiratory allergy and positive skin prick tests (SPTs); 212 (48.5%) patients were sensitized to olive pollen, and 33 (7.5%) patients were sensitized to olive pollen only. Of these patients, 23 received preseasonal immunotherapy with an olive pollen allergoid. The olive pollen-specific basophil activation, the titrated nasal provocation test, the nasal symptom score, and olive pollen-specific IgE, IgG1 and IgG4 levels were evaluated before immunotherapy and 8 months after the end of immunotherapy in the follow-up visit. Results: In comparison to baseline evaluation, 7 preseasonal injections of an allergoid resulted in a significant decrease in the percentage of basophils expressing CD63 (29 vs. 7%, respectively, p < 0.0001) and a significant increase in the titrated nasal provocative dose (1/10 vs. 1/1, respectively, p < 0.01). SPT induration diameters caused by an olive pollen extract decreased (12 mm at baseline vs. 5.5 mm at follow-up, p < 0.005), as did nasal symptom score (7 at baseline vs. 3 at follow-up, p < 0.01). Olive pollen-specific IgE (17.5 vs. 50 kU/l, p < 0.012), IgG1 (0.16 vs. 2.9 µg/ml, p < 0.0001) and IgG4 (0.07 vs. 1.92 µg/ml, p < 0.0001) levels significantly increased. Conclusions: Immunotherapy with 7 preseasonal injections of an olive pollen allergoid decreases olive pollen-specific basophil activation over 8 months, an effect observed in vitro and in vivo.

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Efficacy and Safety of a Glutaraldehyde-Modified House Dust Mite Extract in Allergic Rhinitis

Abstract: The findings of this study indicate that allergen injection therapy with modified HDM extract is superior to placebo in allergic rhinitis therapy. The treatment was well tolerated and no serious drug-related AE were observed.

Cited by 57 publications

References 20 publications

Assessing the Efficacy of Immunotherapy with a Glutaraldehyde-Modified House Dust Mite Extract in Children by Monitoring Changes in Clinical Parameters and Inflammatory Markers in Exhaled Breath

Assessing the Efficacy of Immunotherapy with a Glutaraldehyde-Modified House Dust Mite Extract in Children by Monitoring Changes in Clinical Parameters and Inflammatory Markers in Exhaled Breath

Onset and dose-related efficacy of house dust mite sublingual immunotherapy tablets in an environmental exposure chamber

Desensitization Effect of Preseasonal Seven-Injection Allergoid Immunotherapy with Olive Pollen on Basophil Activation: The Efficacy of Olive Pollen-Specific Preseasonal Allergoid Immunotherapy on Basophils

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