Efficacy and Safety of a Herbal Formula that Mainly Consists of Cornus Officinalis for Erectile Dysfunction: A Double-blind, Placebo-controlled Study

Kam, Sung Chul; Choi, See Min; Jeh, Seong Uk; Lee, Seung Hyun; Hwa, Jeong Seok; Jung, KY; Changwan, Kang; Hyun, Jae Seog

doi:10.4111/kju.2007.48.7.741

Cited by 10 publications

(7 citation statements)

References 10 publications

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“…ED is related to chronic conditions such as atherosclerosis, diabetes mellitus, and obesity that reduce arterial blood flow. Endothelial dysfunction caused by such conditions is considered to be an important factor for ED [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Tadalafil 5 mg Administered Once Daily in Korean Men with Erectile Dysfunction: A Prospective, Multicenter Study

et al. 2010

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PurposeThe aim of this study was to evaluate the efficacy of a daily dose of tadalafil 5 mg as well as its safety for the cardiovascular system in men with erectile dysfunction.Materials and MethodsThis study included a total of 162 men who were administered a daily dose of tadalafil 5 mg between April and December of 2009. A total of 127 men completed the 8-week clinical trial. The International Index of Erectile Function (IIEF)-5, blood pressure, and heart rate were measured before treatment with tadalafil (V1) and 4 (V2) and 8 weeks (V3) after treatment with tadalafil. Adverse effects were assessed at V1, V2, and V3. In cases in which the International Prostate Symptom Score (IPSS) was ≥8 at V1, maximal flow rate (Qmax) and postvoid residual volume (PVR) were measured.ResultsThe IIEF-5 values were 11.25±3.18, 14.56±3.79, and 16.91±3.56 at V1, V2, and V3, respectively, with significant improvement (V1 vs. V2, p<0.001; V1 vs. V3, p<0.001). The IPSS values were 10.59±5.56, 9.07±6.06, and 8.15±6.10 at V1, V2, and V3, respectively, and the differences were statistically significant (V1 vs. V2, p<0.001; V1 vs. V3, p<0.001). There were no significant differences in blood pressure or heart rate. Adverse effects were observed in 7 men (5.51%) at V2 and in 5 men (3.94%) at V3.ConclusionsTadalafil 5 mg administered once-a-day may be effective in improving erectile function. Adverse effects on the cardiovascular system may be minimal. In addition, it is believed that this may also be effective in improving voiding symptoms.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Tadalafil 5 mg Administered Once Daily in Korean Men with Erectile Dysfunction: A Prospective, Multicenter Study

et al. 2010

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“…Chonbo-204® (Korea Bio Medical Science Institute, Seoul, Korea) is based on the ojayounjonghwon described in the Donguibogam and the Asian concepts of yin and yang [ 41 42 ]. The major ingredients of this herbal formula are seeds obtained from five plants: Cornus officinalis Sieb.…”

Section: Types Of Herbal Medicine Used To Treat Electile Dysfunctionmentioning

confidence: 99%

“…The rate of side effects was 7.5% in both groups. The side effects were headache (2.5%) and nausea (5%) [ 42 ].…”

Section: Types Of Herbal Medicine Used To Treat Electile Dysfunctionmentioning

confidence: 99%

Current Status and Clinical Studies of Oriental Herbs in Sexual Medicine in Korea

Shin

Zhao

Zhang

et al. 2015

World J Mens Health

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Erectile dysfunction (ED) is one of the most common diseases among aging men. Although previous studies have shown that type 5 phosphodiesterase inhibitors (PDE5-Is) are very effective for the treatment of ED, many researchers are currently attempting to identify therapeutic agents from natural sources with comparable or better effects than PDE5-Is. Herbal medicine is thought to be advantageous because it is natural; moreover, it not only treats isolated symptoms, but also maintains general well-being. Furthermore, since newly created chemical compound libraries have limited structural diversity with regard to pharmaceutical agents, more attention has recently been paid to the ability of oriental herbs to enhance physical health, including sexual function. Herein, we review the current status of Korean preclinical or clinical studies of the application of oriental herbs to sexual medicine.

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“…A randomized, double‐blind, placebo‐controlled study found that a Chinese herbal formula that was mainly composed of C. officinalis was not only effective at improving erectile function but was also safe for the treatment of ED [27]. It also may enhance the motility of human sperm [28].…”

Section: Discussionmentioning

confidence: 99%

In Vivo and in Vitro Animal Investigation of the Effect of a Mixture of Herbal Extracts from Tribulus terrestris and Cornus officinalis on Penile Erection

Kam

Choi

et al. 2012

The Journal of Sexual Medicine

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Introduction Herbal preparations have long been used as folk remedies for erectile dysfunction (ED). Aim This study examined the effects of Tribulus terrestris and Cornus officinalis extracts on relaxation of the smooth muscle of the corpus cavernosum (CC), their mechanisms of action, and the effects of oral administration of a mixture of the herbal extracts on penile erection. Methods The relaxation effects and the mechanisms of action of T. terrestris extract, C. officinalis extract, and the mixture of both extracts on the rabbit CC were investigated in an organ bath. To evaluate whether the relaxation response of the CC shown in an organ bath occurs in vivo, intracavernous pressure (ICP) was calculated in rats after oral administration for a month. Additionally, adenosine 3′,5′-cyclic monophosphate (cAMP) and guanosine 3′, 5′-cyclic monophosphate (cGMP) in the CC were measured using immunoassay. Main Outcome Measures Smooth muscle relaxation was expressed as the percent decrease in precontraction induced by phenylephrine. ICP was assessed in rats after the oral administration of a mixture of both extracts for 1 month and changes in cGMP and cAMP concentrations were measured based on the concentration of the mixture of both extracts. Results T. terrestris extract, C. officinalis extract, and the mixture of both extracts showed concentration-dependent relaxation effects of the CC. In both the endothelium-removed group and N(G)-nitro-L-arginine methyl ester pretreatment group, T. terrestris extract inhibited relaxation. ICP measured after oral administration of the extract mixture for a month was higher than that measured in the control group, and a significant increase in cAMP was observed in the mixture group. Conclusions T. terrestris extract and C. officinalis extract exhibited concentration-dependent relaxation in an organ bath. In the in vivo study of the extract mixture, ICP and cAMP was significantly potentiated. Accordingly, the mixture of T. terrestris extract and C. officinalis extract may improve erectile function.

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Efficacy and Safety of a Herbal Formula that Mainly Consists of Cornus Officinalis for Erectile Dysfunction: A Double-blind, Placebo-controlled Study

Cited by 10 publications

References 10 publications

Efficacy and Safety of Tadalafil 5 mg Administered Once Daily in Korean Men with Erectile Dysfunction: A Prospective, Multicenter Study

Efficacy and Safety of Tadalafil 5 mg Administered Once Daily in Korean Men with Erectile Dysfunction: A Prospective, Multicenter Study

Current Status and Clinical Studies of Oriental Herbs in Sexual Medicine in Korea

In Vivo and in Vitro Animal Investigation of the Effect of a Mixture of Herbal Extracts from Tribulus terrestris and Cornus officinalis on Penile Erection

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