Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study

Liu, Xiaoqian; Robbins, Sarah R; Eyles, Jillian; Федорова, Т. А.; Virk, Sonika; Deveza, Leticia A; McLachlan, Andrew J.; Hunter, David J.

doi:10.1016/j.joca.2021.01.011

Cited by 19 publications

(12 citation statements)

References 46 publications

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“…Finally, the dosage used in the Liu et al. ( 2021 ) study was below the usual manufacturer-recommended dosage. For example, they used one capsule of Flexofytol corresponding to 46.6 mg of bio-optimized Curcuma longa extracts while the evidenced efficient dose in knee OA was 186.6 mg (Henrotin et al.…”

Section: Discussionmentioning

confidence: 92%

“…In the Liu et al. ( 2021 ) study, there were fewer technology confident participants in the supplement combination group (54%) than in the placebo group (70%). Further, these authors demonstrated that participants with greater technology confidence demonstrated more pain relief with their mixture than those who were not.…”

Section: Discussionmentioning

confidence: 97%

“…Recently, an internet-based, parallel, randomised, placebo-controlled trial concluded that the combination of proprietary products containing Boswellia serrata extract (Boswellin Super), pine bark extract (Fenoprolic 70 organic), and methylsulfonylmethane and curcumin (Flexofytol) had no effect on symptomatic relief in people with symptomatic hand OA (Liu et al. 2021 ). A number of factors may explain the absence of the effect of these compounds.…”

Section: Discussionmentioning

confidence: 99%

“…In the Liu et al. ( 2021 ) study, data were collected online while in our study the data were collected by the physician. This methodological difference is important since it is well-known that in online studies there is a majority of less technology confident participants.…”

Section: Discussionmentioning

confidence: 99%

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Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial

Henrotin

Dierckxsens²,

Delisse³

et al. 2022

Pharmaceutical Biology

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Context Osteoarthritis (OA) of the hand is a common painful musculoskeletal disorder with no cure. There is a need for an efficient and safe treatment to relieve OA pain. Objective To investigate the effects of a Curcuma longa and Boswellia serrata food supplement in addition to standard care on hand pain. Materials and methods This open-label, non-controlled, post-observational study was based on 232 patients suffering from hand pain with or without joint deformity. Patients received a medical prescription for a three-month treatment with a food supplement containing 89 mg of C. longa dry extract, 120 mg of B. serrata resin, and 1.8 µg vitamin D. Pain was evaluated on a 10-point visual analog scale (VAS). The number of painful hand joints, patient satisfaction, nonsteroidal anti-inflammatory drugs intake, and side effects were also recorded. Results Baseline pain intensity (regression coefficient ± SE : −0.19 ± 0.01, p < 0.0001) and the number of painful joints (regression coefficient ± SE : −0.022 ± 0.0029, p < 0.0001) decreased significantly throughout the 3 months treatment period. NSAIDs intake and topical drug application were significantly decreased by 64% ( p < 0.0001) and 79% ( p < 0.0001) after 12 weeks, respectively. Only 3/239 (1.3%) patients reported side effects probably related to the product. 80.3% were satisfied with the treatment and 75.5% wished to continue treatment. Conclusion This is the first clinical trial showing that C. longa and B. serrata resin can relieve symptoms in patients with hand osteoarthritis. The study provides useful information for the design of a clinical trial including a broader population.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial

Henrotin

Dierckxsens²,

Delisse³

et al. 2022

Pharmaceutical Biology

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“…Moreover, curcumin polysorbate formulation Flexofytol remarkably reduced Coll2-1, CRP, and global disease assessment activity in osteoarthritis patients in 3 months . In another study, Flexofytol along with Boswellia extract pine bark extract, and methylsulfonyl methane for 12 weeks reduced activity impairment and FIHOA score without any significant adverse effects in osteoarthritis patients . Another formulation HydroCurc consists of 80% curcumin, 17% demethoxycurcumin, and 3% bisdemethoxycurcumin entrapped in a LipiSperse delivery system, was demonstrated to inhibit the formation of thiobarbituric acid reactive substances (TBARS), TNF-α, IL-6, and relieved fatigue .…”

Section: Curcumin Formulationsmentioning

confidence: 95%

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

et al. 2023

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Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contribute to curcumin’s limited oral bioavailability. In order to improve its oral bioavailability, different formulation techniques such as coadministration with piperine, incorporation into micelles, micro/nanoemulsions, nanoparticles, liposomes, solid dispersions, spray drying, and noncovalent complex formation with galactomannosides have been investigated with in vitro cell culture models, in vivo animal models, and humans. In the current study, we extensively reviewed clinical trials on various generations of curcumin formulations and their safety and efficacy in the treatment of many diseases. We also summarized the dose, duration, and mechanism of action of these formulations. We have also critically reviewed the advantages and limitations of each of these formulations compared to various placebo and/or available standard care therapies for these ailments. The highlighted integrative concept embodied in the development of next-generation formulations helps to minimize bioavailability and safety issues with least or no adverse side effects and the provisional new dimensions presented in this direction may add value in the prevention and cure of complex chronic diseases.

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Bioprospecting Nutraceuticals for Human Welfare

Hegde,

Mishra,

Kunnumakkara

et al. 2024

Biodiversity and Business

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Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study

Cited by 19 publications

References 46 publications

Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial

Curcuma longa and Boswellia serrata extract combination for hand osteoarthritis: an open-label pre-post trial

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Bioprospecting Nutraceuticals for Human Welfare

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