Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial

Lenon, George Binh; Li, Kang Xiao; Chang, Yung‐Hsien; Yang, Angela Wei Hong; Costa, Clifford Da; Li, Chun Guang; Cohen, Marc; Mann, Neil; Xue, Charlie Changli

doi:10.1155/2012/435702

Cited by 43 publications

(63 citation statements)

References 38 publications

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“…Significant decrease in body fat was seen by Xantigen [16], Catechin-enriched green tea [18], Irvingia gabonensis a West African plant [22], RCM-104 a compound of Camellia Sinensis, Semen Cassiae and Flos Sophorae [23], Psyllium Fibre [25], and black Chinese tea [Pu-Erh tea] [26]. Oolong tea showed a decrease in subcutaneous fat content not total body fat [20].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A systematic review of anti-obesity medicinal plants - an update

Hasani‐Ranjbar

Jouyandeh

Abdollahi

2013

J Diabetes Metab Disord

230

163

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Obesity is the most prevalent health problem affecting all age groups, and leads to many complications in the form of chronic heart disease, diabetes mellitus Type 2 and stroke. A systematic review about safety and efficacy of herbal medicines in the management of obesity in human was carried out by searching bibliographic data bases such as, PubMed, Scopus, Google Scholar, Web of Science, and IranMedex, for studies reported between 30th December 2008 to 23rd April 2012 on human or animals, investigating the beneficial and harmful effects of herbal medicine to treat obesity. Actually we limited our search to such a narrow window of time in order to update our article published before December of 2008. In this update, the search terms were “obesity” and (“herbal medicine” or “plant”, “plant medicinal” or “medicine traditional”) without narrowing or limiting search items. Publications with available abstracts were reviewed only. Total publications found in the initial search were 651. Total number of publications for review study was 33 by excluding publications related to animals study.Studies with Nigella Sativa, Camellia Sinensis, Crocus Sativus L, Seaweed laminaria Digitata, Xantigen, virgin olive oil, Catechin enriched green tea, Monoselect Camellia, Oolong tea, Yacon syrup, Irvingia Gabonensi, Weighlevel, RCM-104 compound of Camellia Sinensis, Pistachio, Psyllium fibre, black Chinese tea, sea buckthorn and bilberries show significant decreases in body weight. Only, alginate-based brown seaweed and Laminaria Digitata caused an abdominal bloating and upper respiratory tract infection as the side effect in the trial group. No other significant adverse effects were reported in all 33 trials included in this article.In conclusion, Nigella Sativa, Camellia Synensis, Green Tea, and Black Chinese Tea seem to have satisfactory anti-obesity effects. The effect size of these medicinal plants is a critical point that should be considered for interpretation. Although there was no report for side effect in these trials, we believe that safety of these plants still remains to be elucidated by further long-term studies.

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Section: Resultsmentioning

confidence: 99%

“…An extract of Blueberry Bioactives [34], Epigallocatechin of green tea [35], Northern Berries [36], alginate-based brown seaweed Laminaria Difitata [15], and RCM-104 compound of Camellia Sinensis [23] did not show any relevant decrease in appetite.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of anti-obesity medicinal plants - an update

Hasani‐Ranjbar

Jouyandeh

Abdollahi

2013

J Diabetes Metab Disord

230

163

View full text Add to dashboard Cite

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“…Although weight loss and weight control drugs are common, their medical effects are far from satisfactory since many pharmaceuticals have unwanted side effects [9]. Due to concerns over currently available Western medicine treatments, some have turned to their interest to alternative medicines, including traditional Oriental medicine, for therapeutic treatment of obesity [10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

“…Medicinal plants and their extracts have been verified as beneficial and are the oldest and most widespread form of medication to prevent diet-induced obesity [12,13,14]. Multiple natural products containing numerous bioactive compounds may result in synergistic activity that increases their bioavailability and action on multiple molecular targets.…”

Section: Introductionmentioning

confidence: 99%

Differential Protein Expression in White Adipose Tissue from Obesity-Prone and Obesity-Resistant Mice in Response to High Fat Diet and Anti-Obesity Herbal Medicines

Kim

Park²,

Choi³

et al. 2015

Cell Physiol Biochem

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Background: One of the most interesting issues in obesity research is why certain humans are obesity-prone (OP) while others are obesity-resistant (OR) upon exposure to a high-calorie diet. However, the pathways responsible for these phenotypic differences are still largely unknown. Methods: In order to discover marker molecules determining susceptibility and/or resistance to obesity in response to high fat diet (HFD) or anti-obesity herbal medicine (TH), we conducted comparative proteomic analysis of white adipose tissue (WAT) from OP, OR, as well as TH-treated mice. Results: OP mice fed HFD gained approximately 33% more body weight than OR mice, and TH significantly reduced body weight gain in HFD-fed mice by 30%. These mice were further subjected to proteomic analysis using two-dimensional electrophoresis (2-DE) combined with matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS). Proteomic data revealed 59 spots that were differentially regulated from a total of 1,045 matched spots, and 57 spots of these were identified as altered WAT proteins between OP and OR mice by peptide mass finger printing. Interestingly, 45 proteins were similarly regulated in OR mice in response to TH treatment. Of these, 10 proteins have already been recognized in the context of obesity; however, other proteins involved in obesity susceptibility or resistance were identified for the first time in the present study. Conclusion: Our results suggest that TH actively contributed to body weight reduction in HFD-fed obese mice by altering protein regulation in WAT, and it was also found that TH-responsive proteins can be used as potent molecules for obesity treatment.

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“…Among the many efforts to evaluate the efficacy and safety of herbal antiobesity agents [15, 16], this pilot study is the first randomized clinical trial for Taeeumjowi-tang in the Korean population. …”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Taeeumjowi-tang in Obese Korean Adults: A Double-Blind, Randomized, and Placebo-Controlled Pilot Trial

Park

Nahmkoong

Cheon

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Objective. The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors. Methods. This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 (n = 57) group or the placebo group (n = 55). Subjects were administered 7 g of either TJ001 or placebo 3 times a day. The primary outcome was a rate of subjects who lost 5% or more of initial weight. Secondary outcomes included anthropometric parameters, lipid profiles, and body fat composition. Results. The subject response rate of ≥5% weight loss compared to baseline was similar in both groups, and no statistically significant difference was observed (P = 0.87). Changes in anthropometric parameters were greater during the first 4 weeks in the treatment group (P < 0.0001). There were no significant changes in both within groups and between groups for lipid profile and body fat composition. No adverse event was reported in either group. Conclusion. Although the difference between the groups regarding a rate of subjects who lost 5% or more of initial weight did not show statistical significance, TJ001 appears to be beneficial in safely controlling weight.

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Efficacy and Safety of a Chinese Herbal Medicine Formula (RCM-104) in the Management of Simple Obesity: A Randomized, Placebo-Controlled Clinical Trial

Cited by 43 publications

References 38 publications

A systematic review of anti-obesity medicinal plants - an update

A systematic review of anti-obesity medicinal plants - an update

Differential Protein Expression in White Adipose Tissue from Obesity-Prone and Obesity-Resistant Mice in Response to High Fat Diet and Anti-Obesity Herbal Medicines

Efficacy and Safety of Taeeumjowi-tang in Obese Korean Adults: A Double-Blind, Randomized, and Placebo-Controlled Pilot Trial

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