Aim and Objectives: Rheumatoid arthritis is an auto immune disease and its signs and symptoms are correlated with Uthira vatha Suronitham (UVS) in Siddha. Here we discussed a case series of Rheumatoid arthritis managed by a novel, classical Siddha formulation Amirdha Gandhi Kukkil Vallathy (AGKV). Methods: Three cases were diagnosed as Rheumatoid arthritis (RA) based on ACR/EULAR 2010 criteria, along with symptoms of UVS as per Siddha literature. All the three cases were treated with Siddha medicine AGKV 2 gm bid for 48 days in the General out patients department, Siddha Central Research Institute. Observations: The assessment was made by the signs and symptoms and serological parameters like C-Reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), Haemoglobin (Hb), Rheumatoid Arthritis factor (RA factor). Results: The RA Factor was reduced in all three patients from 60 to 13.9, from 133 to 106, from 60.7 IU/ml to 35.6 IU/ml ; CRP reduced in case 1 from 135.8 to 34.3, case 3 from 18.9 to 5.6, reduction in RAPS score and clinical symptoms were noticed in all three cases and were followed for 1 year and managed with diet advice. This case series highlights that RA can be successfully managed with Siddha herbo mineral preparation AGKV within a minimum period of 48 days. Hence in a long duration of treatment, it will certainly give good results to reduce the burden of RA patients.