Efficacy and safety of acupuncture combined with Chinese Herbal Medicine for diabetic nephropathy

Yu, Ziyang; Zhang, Wenfeng; Li, Borui; Bao, Pengjie; Sun, Jian; Song, Guojiao; Yin, Lu; Nan, Zheng

doi:10.1097/md.0000000000027087

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…The intensity, amplitude and frequency of electroacupuncture stimulation also have clear parameter range. Some scholars have proved that acupuncture combined with Chinese herbal medicine is more effective and safer in the treatment of diabetic neuropathy [ 209 ]. Therefore, the combination of acupuncture and medicine is expected to become a new treatment for AD, and the organic combination of basic and clinical research needs to be further strengthened, improve research level, perfect the unified diagnosis and curative effect evaluation standard, to gradually achieve objective research, standardization, standardization, for a variety of different stitch to strengthen clinical design scientific, rigor, at the same time, It is necessary to continue to strengthen the organic combination of clinical research and experimental research.…”

Section: Discussionmentioning

confidence: 99%

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Chen,

Wang,

et al. 2024

Chin Med

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Alzheimer’s disease (AD) is a neurodegenerative disease with insidious onset and progressive development. It is clinically characterized by cognitive impairment, memory impairment and behavioral change. Chinese herbal medicine and acupuncture are important components of traditional Chinese medicine (TCM), and are commonly used in clinical treatment of AD. This paper systematically summarizes the research progress of traditional Chinese medicine natural products and acupuncture treatment of AD, which combined with existing clinical and preclinical evidence, based on a comprehensive review of neuroinflammation, and discusses the efficacy and potential mechanisms of traditional Chinese medicine natural products and acupuncture treatment of AD. Resveratrol, curcumin, kaempferol and other Chinese herbal medicine components can significantly inhibit the neuroinflammation of AD in vivo and in vitro, and are candidates for the treatment of AD. Acupuncture can alleviate the memory and cognitive impairment of AD by improving neuroinflammation, synaptic plasticity, nerve cell apoptosis and reducing the production and aggregation of amyloid β protein (Aβ) in the brain. It has the characteristics of early, safe, effective and benign bidirectional adjustment. The purpose of this paper is to provide a basis for improving the clinical strategies of TCM for the treatment of AD. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Chen,

Wang,

et al. 2024

Chin Med

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“…In recent years, more and more studies have demonstrated the unique advantages of acupuncture combined with conventional medications in treating DKD ( 12 ). Acupuncture has been reported to reduce proteinuria, glycemia, and lipids and improve patients’ quality of life with DKD ( 13 ). However, the specific benefits and acupoints selection of acupuncture for DKD is still controversial.…”

Section: Introductionmentioning

confidence: 99%

A strategic study of acupuncture for diabetic kidney disease based on meta-analysis and data mining

Yu,

Hu,

Yang

et al. 2024

Front. Endocrinol.

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ObjectiveThe specific benefit and selection of acupoints in acupuncture for diabetic kidney disease (DKD) remains controversial. This study aims to explore the specific benefits and acupoints selection of acupuncture for DKD through meta-analysis and data mining.MethodsClinical trials of acupuncture for DKD were searched in eight common databases. Meta-analysis was used to evaluate its efficacy and safety, and data mining was used to explore its acupoints selection.ResultsMeta-analysis displayed that compared with the conventional drug group, the combined acupuncture group significantly increased the clinical effective rate (risk ratio [RR] 1.35, 95% confidence interval [CI] 1.20 to 1.51, P < 0.00001) and high-density lipoprotein cholesterol (mean difference [MD] 0.36, 95% CI 0.27 to 0.46, P < 0.00001), significantly reduced the urinary albumin (MD –0.39, 95% CI –0.42 to –0.36, P < 0.00001), urinary microalbumin (MD –32.63, 95% CI –42.47 to –22.79, P < 0.00001), urine β2-microglobulin (MD –0.45, 95% CI –0.66 to –0.24, P < 0.0001), serum creatinine (MD –15.36, 95% CI –21.69 to –9.03, P < 0.00001), glycated hemoglobin A1c (MD –0.69, 95% CI –1.18 to –0.19, P = 0.006), fasting blood glucose (MD –0.86, 95% CI –0.90 to –0.82, P < 0.00001), 2h postprandial plasma glucose (MD –0.87, 95% CI –0.92 to –0.82, P < 0.00001), total cholesterol (MD –1.23, 95% CI –2.05 to –0.40, P = 0.003), triglyceride (MD –0.69, 95% CI –1.23 to –0.15, P = 0.01), while adverse events were comparable. Data mining revealed that CV12, SP8, SP10, ST36, SP6, BL20, BL23, and SP9 were the core acupoints for DKD treated by acupuncture.ConclusionAcupuncture improved clinical symptoms, renal function indices such as uALB, umALB, uβ2-MG, and SCR, as well as blood glucose and blood lipid in patients with DKD, and has a favorable safety profile. CV12, SP8, SP10, ST36, SP6, BL20, BL23, and SP9 are the core acupoints for acupuncture in DKD, and this program is expected to become a supplementary treatment for DKD.

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“…It provides the genetic targets of chemical components, biological targets and biological functions to predict the mechanism of certain compounds in vivo. Network pharmacology is an effective tool to clarify the pharmacological effects of traditional Chinese medicine [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism of Gynostemma pentaphyllum in the Treatment of Type II Diabetes by Regulating the IRS1/PI3K/Akt Signaling Pathway

Yang,

Zhao,

et al. 2024

CIMB

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Gynostemma pentaphyllum (Thunb.) Makino (GP), a plant with homology of medicine and food, as a traditional Chinese medicine, possesses promising biological activities in the prevention and treatment of type 2 diabetes mellitus (T2DM). However, the material basis and the mechanism of action of GP in the treatment of T2DM have not been fully elucidated. This study aimed to clarify the active components, potential targets and signaling pathways of GP in treating T2DM. The chemical ingredients of GP were collected by combining UPLC-HRMS analysis and literature research. Network pharmacology revealed that GP had 32 components and 326 potential targets in treating T2DM. The results showed that GP affected T2DM by mediating the insulin resistance signaling pathway, PI3K/Akt signaling pathway and FoxO1 signaling pathway, which had a close relationship with T2DM. Molecular docking results showed that STAT3, PIK3CA, AKT1, EGFR, VEGFA and INSR had high affinity with the active compounds of GP. In vitro, GP extracts obviously increased the glucose uptake and glucose consumption in IR-HepG2 cells. GP extracts increased the levels of PI3K, p-AKT, p-GSK3β and p-FoxO1 and decreased the expression of p-IRS1, p-GS, PEPCK and G6Pase, which indicated that GP could promote glycogen synthesis and inhibit gluconeogenesis by regulating the IRS1/PI3K/Akt signaling pathway. The results demonstrated that GP could improve insulin resistance by promoting glucose uptake and glycogen synthesis and inhibiting gluconeogenesis through regulating the IRS1/PI3K/Akt signaling pathway, which might be a potential alternative therapy for T2DM.

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Efficacy and safety of acupuncture combined with Chinese Herbal Medicine for diabetic nephropathy

Cited by 6 publications

References 22 publications

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

A strategic study of acupuncture for diabetic kidney disease based on meta-analysis and data mining

Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism of Gynostemma pentaphyllum in the Treatment of Type II Diabetes by Regulating the IRS1/PI3K/Akt Signaling Pathway

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