Efficacy and safety of acupuncture for recurrent aphthous stomatitis: a systematic review protocol

Zhang, Feng; Zhou, Hao; Ding, Song-Yi; Zhang, Da; Lian, Daoshi; Chen, Xingliang; Wang, Chao

doi:10.1136/bmjopen-2020-037603

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Acupuncture, as an important part of complementary and alternative therapies, has numerous advantages, such as wide indication, reliable curative effect, convenient operation, economic safety, and has been widely accepted and applied worldwide [25]. Acupoints on the meridians are stimulated by using disposable sterile acupuncture needles [26]. A growing number of randomized controlled trials (RCT) have indicated that acupuncture could improve sleep quality, prolong sleep time, reduce the severity of insomnia disorder among the elderly [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Acupuncture methods for insomnia disorder in the elderly: protocol for a systematic review and network meta-analysis

Dong

Zhou

et al. 2023

Syst Rev

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Background Insomnia disorder remains one of the most common sleep disorders in the elderly, with high prevalence and substantial consequences for patients’ general health. Despite that increasing clinical trials have indicated that acupuncture seems to be effective for insomnia disorder in the elderly, comparative efficacy and safety of different acupuncture methods for elderly individuals with insomnia disorder has been unclear. Therefore, this protocol outlined a plan to evaluate and rank the efficacy and safety of various acupuncture approaches for insomnia disorder in the elderly. Methods A systematic search of 8 bibliographic databases will be conducted from their inception to 18 June 2023, including Cochrane Library, MEDLINE (via PubMed), Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Database, and Chinese Biomedical Literature Database (CBM). Randomized controlled trials investigating acupuncture methods for insomnia disorder in the elderly, published in English or Chinese will be included. The primary outcome is sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI). Two reviewers will independently perform study selection, data extraction and risk assessment of bias. The quality of included literatures will be appraised using Cochrane risk-of-bias tool (ROB 2.0). ADDIS (Aggregate Data Drug Information System) V.1.16.8 will be used to conduct Bayesian network meta-analysis. The quality of evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation System (GRADE). Discussion In this study, the results will provide credible evidence to assess the efficacy and safety of acupuncture therapies for elderly patients with insomnia disorder, assisting patients, physicians and clinical research investigators to select the most appropriate acupuncture method. Systematic review registration The protocol has been registered at OSF (https://osf.io/3kjpq/) with a registration number https://doi.org/10.17605/OSF.IO/3KJPQ.

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Section: Introductionmentioning

confidence: 99%

Acupuncture methods for insomnia disorder in the elderly: protocol for a systematic review and network meta-analysis

Dong

Zhou

et al. 2023

Syst Rev

Self Cite

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“…Currently, the World Health Organization recommends acupuncture for the treatment of 16 inflammatory pain-related diseases, including rheumatoid arthritis (RA), acute gastritis, chronic gastritis, frozen shoulder, and allergic rhinitis ( WHO, 2013 ). Evidence shows that acupuncture can be a low-cost, low-risk therapy with few and minor adverse effects and it can help in the management of diseases involving inflammatory pain and reduce reliance on analgesics, including morphine ( Qin et al, 2016 ; Wu et al, 2018 ; A-Wang et al, 2020 ; Zhang et al, 2020a ). In patients with knee osteoarthritis (KOA), acupuncture can significantly relieve pain, attenuate the decline in physical function, and improve quality of life ( Corbett et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Role of Neuroimmune Crosstalk in Mediating the Anti-inflammatory and Analgesic Effects of Acupuncture on Inflammatory Pain

Dou

et al. 2021

Front. Neurosci.

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Inflammatory pain is caused by peripheral tissue injury and inflammation. Inflammation leads to peripheral sensitization, which may further cause central sensitization, resulting in chronic pain and progressive functional disability. Neuroimmune crosstalk plays an essential role in the development and maintenance of inflammatory pain. Studies in recent years have shown that acupuncture can exert anti-inflammatory and analgesic effects by regulating peripheral (i.e., involving local acupoints and inflamed regions) and central neuroimmune interactions. At the local acupoints, acupuncture can activate the TRPV1 and TRPV2 channels of mast cells, thereby promoting degranulation and the release of histamine, adenosine, and other immune mediators, which interact with receptors on nerve endings and initiate neuroimmune regulation. At sites of inflammation, acupuncture enables the recruitment of immune cells, causing the release of opioid peptides, while also exerting direct analgesic effects via nerve endings. Furthermore, acupuncture promotes the balance of immune cells and regulates the release of inflammatory factors, thereby reducing the stimulation of nociceptive receptors in peripheral organs. Acupuncture also alleviates peripheral neurogenic inflammation by inhibiting the release of substance P (SP) and calcitonin gene-related peptide from the dorsal root ganglia. At the central nervous system level, acupuncture inhibits the crosstalk between glial cells and neurons by inhibiting the p38 MAPK, ERK, and JNK signaling pathways and regulating the release of inflammatory mediators. It also reduces the excitability of the pain pathway by reducing the release of excitatory neurotransmitters and promoting the release of inhibitory neurotransmitters from neurons and glial cells. In conclusion, the regulation of neuroimmune crosstalk at the peripheral and central levels mediates the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain in an integrated manner. These findings provide novel insights enabling the clinical application of acupuncture in the treatment of inflammatory diseases.

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Efficacy and safety of acupuncture for recurrent aphthous stomatitis: a systematic review protocol

Cited by 2 publications

References 14 publications

Acupuncture methods for insomnia disorder in the elderly: protocol for a systematic review and network meta-analysis

Acupuncture methods for insomnia disorder in the elderly: protocol for a systematic review and network meta-analysis

Role of Neuroimmune Crosstalk in Mediating the Anti-inflammatory and Analgesic Effects of Acupuncture on Inflammatory Pain

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