Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial

Kaasch, Achim J; López-Cortés, Luis Eduardo; Rodríguez-Baño, Jesús; Cisneros, José Miguel; Dolores Navarro, M; Fätkenheuer, Gerd; Jung, Norma; Rieg, Siegbert; Lepeule, Raphaël; Coutte, Laetitia; Bernard, Louis; Lemaignen, Adrien; Kösters, Katrin; MacKenzie, Colin R; Soriano, Alex; Hagel, Stefan; Fantin, Bruno; Lafaurie, Matthieu; Talarmin, Jean-Philippe; Dinh, Aurélien; Guimard, Thomas; Boutoille, David; Welte, Tobias; Reuter, Stefan; Kluytmans, Jan; Martin, Maria Luisa; Forestier, Emmanuel; Stocker, Hartmut; Vitrat, Virginie; Tattevin, Pierre; Rommerskirchen, Anna; Noret, Marion; Adams, Anne; Kern, Winfried V; Hellmich, Martin; Seifert, Harald; Valiente, Adoración; de Cueto, Marina; Rodríguez, Ángel; Molina, José; Fischer, Julia; Paul, Gregor; Gallien, Sébastien; Fihman, Vincent; Lacasse, Marion; Coustillères, Francois; Becker, Christian; Fuchs, André; Morata, Laura; Weis, Sebastian; Ponscarme, Diane; Khatchatourian, Lydie; Rouveix, Elisabeth; Merrien, Dominique; Lecomte, Raphaël; Veenemans, Jacobien; Vilchez, Helem H.; Kessel, Johanna; Bonten, Marc J.M.; Rupp, Jan; Hocqueloux, Laurent; Lucht, Frederic; Stahl, Jean-Paul; Vlek, Anne; Prinz-Langenohl, Reinhild; Tolsma, Violaine

doi:10.1016/s1473-3099(23)00756-9

The Lancet Infectious Diseases

2024

DOI: 10.1016/s1473-3099(23)00756-9

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Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial

Achim J Kaasch,

Luis Eduardo López-Cortés,

Jesús Rodríguez-Baño

et al.

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Cited by 19 publications

References 36 publications

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Adherence to and clinical utility of “quality indicators” for Staphylococcus aureus bacteremia: a retrospective, multicenter study

Fukushima,

Hagiya,

Kuninaga

et al. 2024

Infection

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Background We aimed to improve the prognosis, treatment, and management of Staphylococcus aureus bacteremia (SAB) by evaluating the association between adherence to quality indicators (QIs) and clinical outcomes in patients with their clinical outcomes. Methods We retrospectively collected clinical and microbiological data on hospitalized patients with SAB from 14 hospitals (three with > 600, two with 401–600, five with 201–400, and four with ≤ 200 beds) in Japan from January to December 2022. The SAB management quality was evaluated using the SAB-QI score (ranging from 0 to 13 points), which consists of 13 QIs (grouped into five categories) based on previous literature. Results Of the 4,448 positive blood culture episodes, 289 patients with SAB (6.5%) were enrolled. The SAB-QI scores ranged from 3 to 13, with a median score of 9 points. The SAB-QI score was highest in middle-sized hospitals with 401–600 beds. Adherence to each of the four QI categories (blood culture, echocardiography, source control, and antibiotic treatment) was significantly higher in survived cases than in fatal cases. Kaplan–Meier curves with log-rank tests demonstrated that higher adherence to SAB-QIs indicated a better prognosis. Logistic regression analysis revealed that age, methicillin resistance, multiple comorbidities (≥ 2), and low SAB-QI score were significantly associated with 30-day mortality in patients with SAB. Conclusions Our study highlights that greater adherence to the SAB-QIs correlates with improved patient outcomes. Management of patients with SAB should follow these recommended indicators to maintain the quality of care, especially for patients with poor prognosticators.

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Adherence to and clinical utility of “quality indicators” for Staphylococcus aureus bacteremia: a retrospective, multicenter study

Fukushima,

Hagiya,

Kuninaga

et al. 2024

Infection

View full text Add to dashboard Cite

show abstract

Treatment of Complicated Gram-Positive Bacteremia and Infective Endocarditis

Schellong,

Joean,

Pletz

et al. 2024

Drugs

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Staphylococcus aureus bacteraemia for the general physician: A narrative review of a metastatic infection with malignant complications

Shah,

Baltas

2024

Clinical Medicine

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Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial

Cited by 19 publications

References 36 publications

Adherence to and clinical utility of “quality indicators” for Staphylococcus aureus bacteremia: a retrospective, multicenter study

Adherence to and clinical utility of “quality indicators” for Staphylococcus aureus bacteremia: a retrospective, multicenter study

Treatment of Complicated Gram-Positive Bacteremia and Infective Endocarditis

Staphylococcus aureus bacteraemia for the general physician: A narrative review of a metastatic infection with malignant complications

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