2016
DOI: 10.1186/s13045-016-0340-8
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Efficacy and safety of angiogenesis inhibitors in advanced gastric cancer: a systematic review and meta-analysis

Abstract: Monoclonal antibodies and small molecule tyrosine kinase inhibitors (TKIs) directed against the vascular endothelial growth factor (VEGF) or its receptors have been investigated in several studies for the treatment of advanced gastric cancer (GC). In the present study, we aimed to evaluate the efficacy and safety of angiogenesis inhibitors in advanced GC. We searched published randomized controlled trials (RCTs) comparing angiogenesis inhibitors with non-angiogenesis inhibitors for the treatment of GC. MEDLINE… Show more

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Cited by 49 publications
(40 citation statements)
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“…Antiangiogenic TKIs such as those inhibiting vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) appear to have a higher reported incidence of diarrhea in the human literature compared with nonangiogenic TKIs . This might suggest a possible relationship between angiogenic signaling inhibition and the development of diarrhea .…”
Section: Discussionmentioning
confidence: 99%
“…Antiangiogenic TKIs such as those inhibiting vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) appear to have a higher reported incidence of diarrhea in the human literature compared with nonangiogenic TKIs . This might suggest a possible relationship between angiogenic signaling inhibition and the development of diarrhea .…”
Section: Discussionmentioning
confidence: 99%
“…For instance, targeting the VEGF pathway in gastric cancers has gained increasing attention after the results obtained in phase III clinical trials, which demonstrate superior survival outcome with some anti-angiogenic drugs, such as ramucirumab, apatinib, and bevacizumab, than with the standard therapy [38]. Nevertheless, further studies are required to deeply explore the timing and potentially predictive biomarkers of angiogenesis inhibitors to improve the selection of patients and improve clinical benefit.…”
Section: Discussionmentioning
confidence: 99%
“…However, except for ramucirumab, most of these antiangiogenic agents failed to improve the patients' survival condition [12,13]. Recently in 2014, apatinib, a kind of selective vascular endothelial growth factor receptor-(VEGFR-) 2 inhibitor, has been approved and showed good treatment efficacy for advanced gastric cancer [14].…”
Section: Introductionmentioning
confidence: 99%