Efficacy and safety of antibiotic therapy for post-Lyme disease? A systematic review and network meta-analysis

Zhang, Xiaoqian; Jiang, Yuwei; Chen, Yihan; Yang, Jiaru; Zhang, Xiaoqi; Xing, Lu; Liu, Aihua; Bao, Fukai

doi:10.1186/s12879-023-07989-4

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…A recent Chinese systematic review on treatment of PTLDs reports contradicting results to our review [40]. Zhang et al.…”

Section: Discussioncontrasting

confidence: 86%

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Treatment of post‐treatment Lyme disease symptoms—a systematic review

Dersch,

Torbahn,

Rauer

2024

Euro J of Neurology

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Background and purposeResidual symptoms after treatment of Lyme disease, sometimes called post‐treatment Lyme disease symptoms (PTLDs), are a matter of ongoing controversy. To guide treatment recommendations, a systematic review was performed of the available literature on specific treatment for PTLDs.MethodsA systematic literature search of MEDLINE and CENTRAL was performed. No restrictions on case definitions, study types or specific interventions were applied to enable a comprehensive overview of the available literature. Risk of bias was assessed using the Cochrane risk of bias tools for randomized controlled trials. Certainty of the evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation approach. Outcomes of interest were quality of life, fatigue, depression and cognition as well as adverse events.ResultsAfter screening 1274 records, eight eligible randomized controlled trials were included. Heterogeneity was observed regarding inclusion criteria, intervention, length of treatment and outcome measures. For efficacy outcomes, results are presented narratively due to heterogeneity. Eligible studies show no statistically significant difference between antibiotics and placebo regarding quality of life, cognition and depression. Results for fatigue were inconsistent whilst studies with low risk of bias showed no statistically significant difference between antibiotics and placebo. Meta‐analysis of safety outcomes showed statistically significantly more adverse events for antibiotics compared to placebo.ConclusionsAvailable literature on treatment of PTLDs is heterogeneous, but overall shows evidence of no effect of antibiotics regarding quality of life, depression, cognition and fatigue whilst showing more adverse events. Patients with suspected PTLDs should not be treated with antibiotics.

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“…A recent Chinese systematic review on treatment of PTLDs reports contradicting results to our review [40]. Zhang et al.…”

Section: Discussioncontrasting

confidence: 86%

“…A recent Chinese systematic review on treatment of PTLDs reports contradicting results to our review [40]. Zhang et al published a network meta-analysis on antibiotic treatment of PTLDs and reported a superior efficacy of ceftriaxone over doxycycline and placebo regarding fatigue.…”

Section: Risk Of Biascontrasting

confidence: 87%

Treatment of post‐treatment Lyme disease symptoms—a systematic review

Dersch,

Torbahn,

Rauer

2024

Euro J of Neurology

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“…Honey has been found to have antibacterial activity against H. pylori, while propolis has been shown to inhibit H. pylori growth and reduce H. pylori-induced inflammation. Probiotics, particularly strains of Lactobacillus and Bifidobacterium, have been found to have anti-H. pylori activity and can reduce the incidence of H. pylori-related diseases [9].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies

Addissouky,

Ali,

El Tantawy El Sayed

et al. 2023

Arch Pharmacol Ther

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Helicobacter pylori (H. pylori) infection is a major global health concern, with an estimated 50% of the world's population infected. The bacterium colonizes the stomach and is associated with a range of gastrointestinal diseases, including chronic gastritis, peptic ulcers, and gastric cancer. The current standard of care for H. pylori infection involves a combination of antibiotics and proton pump inhibitors (PPIs), but the widespread use of antibiotics has led to the development of antibiotic-resistant strains of H. pylori, making treatment more difficult. Recent advances in diagnostic strategies include the use of non-invasive tests and serological biomarkers. While the use of antibiotics and PPIs remains the primary treatment approach, there is a growing interest in alternative therapies, including botanical extracts, natural products, and traditional medicines. Recent research has also explored the potential of probiotics, phage therapy, and novel antibiotics, such as rifabutin and furazolidone, in the treatment of H. pylori infection. Recent studies have also explored the potential of artificial intelligence (AI) in the diagnosis and management of H. pylori infection. AI-assisted screening methods have identified novel botanical extracts and natural products with anti-H. pylori activity, providing new avenues for therapeutic development. Additionally, AI can improve diagnostic accuracy and treatment outcomes. Although these alternative approaches show promise, further research is needed to confirm their efficacy, safety, and optimal dosing. Novel therapies such as phage therapy and new antibiotics may provide an alternative to traditional treatments and help overcome antimicrobial resistance.

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“…Noroviruse infection can result in dehydration, especially in young children, older adults, and individuals with compromised immune systems. (3, 4). Noroviruses have the ability to infect not only humans but also a diverse range of other mammalian hosts.…”

Section: Introductionmentioning

confidence: 99%

Detection of Noroviruses GII in wastewater samples of Bhopal, India, using Droplet Digital PCR

Nema,

Nagar,

Singh

et al. 2023

Preprint

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Noroviruses are a significant cause of global gastroenteritis outbreaks, underscoring the importance of effective surveillance. Wastewater-based epidemiology helps identify viral pathogens in communities. Recent advancements in wastewater-based molecular surveillance have shown that viruses can be detected in feces and urine early, making sewage monitoring an essential tool for tracking viral presence. We aimed to create and validate a new method for detecting and monitoring Noroviruses GII in Bhopal’s wastewater using Automated Droplet Digital PCR (ddPCR) technology. In this study, a ddPCR assay targeting the ORF1-2 region of Norovirus GII was developed, allowing viral nucleic acid quantification without a standard curve. A total of 27 samples from five Sewage Treatment Plants located in Bhopal city were collected during the summer season (April and May 2023) at fortnightly intervals and analyzed for the presence of Norovirus using the novel ddPCR assay. Among the samples tested, 33% tested positive for Norovirus, with the highest detection rate observed as 72.72%, followed by 25%. The concentrations of Noroviruses GII in positive samples ranged from 0.06 to 6.60 copies/µl. These findings indicate a potentially higher patient population within Bansal Hospital’s catchment area than the other STPs in the Bhopal region. The study underscores Norovirus’s varying prevalence and distribution in wastewater across different STPs in Bhopal. Moreover, it demonstrates the utility of wastewater surveillance and digital PCR in accurately and specifically detecting Norovirus in wastewater. The practical application of this wastewater surveillance strategy could serve as an early warning system for communities, enabling timely preparedness for impending viral outbreaks, implementation of effective administrative containment measures, and intensified vaccination campaigns.

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Efficacy and safety of antibiotic therapy for post-Lyme disease? A systematic review and network meta-analysis

Cited by 4 publications

References 29 publications

Treatment of post‐treatment Lyme disease symptoms—a systematic review

Treatment of post‐treatment Lyme disease symptoms—a systematic review

Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies

Detection of Noroviruses GII in wastewater samples of Bhopal, India, using Droplet Digital PCR

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