Efficacy and safety of antifibrinolytics in oncological surgery: a systematic review and meta-analysis

Sampaio, Aline Menezes; Guimarães, Gabriel Magalhães Nunes; Medeiros, Germano Pinheiro; Damasceno, Germana Medeiros Mendes; Silva, Ricardo Martins de Abreu; Nunes, Rogean Rodrigues; Rocha, Hermano Alexandre Lima; Nascimento, José Carlos Rodrigues

doi:10.1016/j.bjane.2019.06.003

Cited by 2 publications

(1 citation statement)

References 38 publications

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“… 38 For this reason, the safety of these drugs in patients excluded from clinical trials is poorly understood. Recently, meta-analyses evaluating some studies that included these patients demonstrated similar incidence of adverse effects to those that excluded them, 41 , 42 , 43 raising questions about the need to exclude these patients in future trials. The favorable results in efficacy and safety for the prophylactic use of antifibrinolytics assigned them a central role in blood conservation programs, such as Patient Blood Management.…”

Section: Indications Of Antifibrinolytics Versus Mechanisms Of Hyperf...mentioning

confidence: 99%

Perioperative hyperfibrinolysis – physiology and pathophysiology

Marinho

2021

Brazilian Journal of Anesthesiology (English Edition)

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Section: Indications Of Antifibrinolytics Versus Mechanisms Of Hyperf...mentioning

confidence: 99%

Perioperative hyperfibrinolysis – physiology and pathophysiology

Marinho

2021

Brazilian Journal of Anesthesiology (English Edition)

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Can the prophylactic administration of tranexamic acid reduce the blood loss after robotic-assisted radical prostatectomy? Robotic Assisted Radical Prostatectomy with tranEXamic acid (RARPEX): study protocol for a randomized controlled trial

Balík

Košina

Hušek

et al. 2022

Trials

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Background The prophylactic administration of tranexamic acid reduces blood loss during procedures at high risk of perioperative bleeding. Several studies in cardiac surgery and orthopedics confirmed this finding. The aim of this prospective, double-blind, randomized study is to evaluate the effect of tranexamic acid on peri-and postoperative blood loss and on the incidence and severity of complications. Methods/design Based on the results of our pilot study, we decided to conduct this prospective, double-blind, randomized trial to confirm the preliminary data. The primary endpoint is to analyze the effect of tranexamic acid on perioperative and postoperative blood loss (decrease in hemoglobin levels) in robotic-assisted radical prostatectomy. The additional endpoint is to analyze the effect of tranexamic acid on postoperative complications and confirm the safety of tranexamic acid in robotic-assisted radical prostatectomy. Discussion No study to date has tested the prophylactic administration of tranexamic acid at the beginning of robotic-assisted radical prostatectomy. This study is designed to answer the question of whether the administration of tranexamic acid might lower the blood loss after the procedure or increase the rate and severity of complications. Trial registration ClinicalTrials.gov NCT04319614. Registered on 25 March 2020

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Efficacy and safety of antifibrinolytics in oncological surgery: a systematic review and meta-analysis

Cited by 2 publications

References 38 publications

Perioperative hyperfibrinolysis – physiology and pathophysiology

Perioperative hyperfibrinolysis – physiology and pathophysiology

Can the prophylactic administration of tranexamic acid reduce the blood loss after robotic-assisted radical prostatectomy? Robotic Assisted Radical Prostatectomy with tranEXamic acid (RARPEX): study protocol for a randomized controlled trial

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