2021
DOI: 10.1111/jog.14964
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Efficacy and safety of autologous platelet‐rich fibrin for the treatment of infertility with intrauterine adhesions

Abstract: Aim To evaluate the efficacy and safety of autologous platelet‐rich fibrin (PRF) for the treatment of infertility with intrauterine adhesions. Methods Forty patients who suffered from infertility with intrauterine adhesions (IUAs) were enrolled in this prospective trial from October 2018 to December 2019. They were randomly divided into a PRF group and a control group. Both groups underwent transcervical resection of adhesions (TCRA) during the follicular phase. PRF group: PRF prepared from autologous venous b… Show more

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Cited by 12 publications
(8 citation statements)
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“…Intrauterine administration of PRF was demonstrated to stimulate damaged endometrium regeneration in rats [21]. Moreover, PRF was placed into the uterine cavity of infertility patients with intrauterine adhesions (IUAs), leading to an increase in the pregnancy rate [23].…”
Section: Embryo Implantationmentioning
confidence: 99%
See 1 more Smart Citation
“…Intrauterine administration of PRF was demonstrated to stimulate damaged endometrium regeneration in rats [21]. Moreover, PRF was placed into the uterine cavity of infertility patients with intrauterine adhesions (IUAs), leading to an increase in the pregnancy rate [23].…”
Section: Embryo Implantationmentioning
confidence: 99%
“…The application of PRF gel demonstrated a therapeutic effect on thin endometrium in rats, increasing endometrium thickness and enhancing marker expression, indicating potential for treating a thin endometrium [22]. Moreover, the efficacy and safety of autologous PRF gel for the treatment of infertility with intrauterine adhesions were identified [23]. The use of PRF lysate has not been widely publicized in vitro and in vivo, despite the fact that PRF is already employed in the wound healing field [6].…”
Section: Introductionmentioning
confidence: 99%
“…Traditional 2D culture achieve the survival of follicles in vitro, but cannot maintain the normal morphology of follicles (Desai et al, 2012;Choi et al, 2013), the 3D structure of the swollen hydrogels maintains the normal morphology of the follicles in vitro. Hydrogels are promisingly applied to treat IUA, because hydrogels are not easily expelled due to the strong adhesion to uterine walls Yang et al, 2020), and the stable 3D structure due to swelling prevents adjacent uterine walls from directly contacting (Mettler et al, 2008;Wang, Z. et al, 2021).…”
Section: Physicochemical Propertiesmentioning
confidence: 99%
“…PRP is obtained by centrifuging peripheral blood, resulting in a platelet concentration that is 4-5 times higher than peripheral blood (11,12). In recent years, intrauterine PRP infusion has been used as an adjuvant therapy to TCRA to improve clinical outcomes in IUA patients (13). However, the efficacy of PRP for IUA patients remains controversial and requires further evidence-based medical research.…”
Section: Introductionmentioning
confidence: 99%