Efficacy and Safety of Autologous Fat Transfer in Facial Reconstructive Surgery

Krastev, Todor K.; Beugels, Jop; Hommes, Juliëtte; Piatkowski, Andrzej; Mathijssen, Irene M.J.; Hulst, René van der

doi:10.1001/jamafacial.2018.0102

Cited by 67 publications

(81 citation statements)

References 57 publications

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“…Therefore, it may not be advisable to use fat as a reconstructive tool to fill in asymmetric facial defects, especially in the younger patient and/or in the patient with a highly unstable weight history. 5 Where fat fails, hyaluronic acid fillers may be used to achieve the desired ends and, as stated, oftentimes can be quite durable after repeated sessions. In fact, it is important for patients who are electing to undergo fat grafting to know that they would most likely benefit from filler treatments toward the end of the first postoperative year for two reasons.…”

mentioning

confidence: 99%

Fat Grafting for Facial Contouring

Lam¹

2019

Facial plast Surg

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Fat grafting is a safe, effective method for facial rejuvenation if used to restore lost facial volume, but it is not as a method to correct cutaneous deformities and rhytids, or to counteract gravitational effects. The most significant postoperative complication is weight gain that can make a face look overinflated. Accordingly, it is important to select a safe and appropriate candidate. This article outlines who is a suitable prospect for fat grafting and juxtaposes the two methods of facial volume restoration: fat grafting versus injectable fillers. Then a detailed exposition of the operative technique is outlined, including anesthesia, harvesting, processing, and injection. Finally, this article concludes with a description of the postoperative course and the management of potential complications.

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mentioning

confidence: 99%

Fat Grafting for Facial Contouring

Lam¹

2019

Facial plast Surg

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“…To achieve these desired results, only one or two treatment sessions of autologous lipofilling were needed with an incidence of clinical related complications of 4.8%. 89 The majority of complications consisted of asymmetry or irregularities (3.7%) and a small number of hematomas (0.6%), infections (0.1%), and hematomas (0.1%) were mentioned.…”

Section: Clinical Evidence Of Facial Lipofilling To Restore Loss Of Vmentioning

confidence: 96%

“…5). 88,89 In reconstructive cases, 91.1% of the patients and 88.6% of the surgeons are satisfied after autologous lipofilling with a mean follow-up of 2 and 1.2 years, respectively. The retention rate of injected fat in reconstructive cases was between 50 and 60% of the injected volume.…”

Section: Clinical Evidence Of Facial Lipofilling To Restore Loss Of Vmentioning

confidence: 99%

The Development of Facial Lipofilling from a Historical Point of View

Dongen

Harmsen

Stevens³

2019

Facial plast Surg

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Lipofilling, the transplantation of adipose tissue, has already been used since the end of the 19th century. For decades, lipofilling was used to restore loss of volume due to aging, trauma, or congenital defects. Later on, the indications for the use of lipofilling expanded by treating aged skin, scars, and improving wound healing. The expansion was caused by the discovery of adipose derived stromal cells (ASCs) in adipose tissue and the development of very fine harvesting and injection cannulas which made it possible to inject small adipose tissue particles in small volume areas, such as the face. ASCs are multipotent stromal cells which reside in the stromal vascular fraction (SVF) of adipose tissue and are able to differentiate in multiple cell lineages and secrete a plurality of growth factors with regenerative potentials. The discovery of ASCs led toward more experimental cell-based therapies, that is, ASCs or SVF isolated by means of enzymatic isolation procedures. Later on, enzymatic isolation procedures were forbidden in many countries by legislation and were replaced by mechanical isolation procedures, such as the Nanofat and Fractionation of Adipose Tissue (FAT) procedures. The Nanofat procedure has been extensively investigated, especially as treatment for skin rejuvenation in the face. Though, substantial evidence is lacking for using facial lipofilling or any therapeutic component, that is, ASCs or SVF for skin rejuvenation to date. In contrast, facial lipofilling to restore loss of volume seems to be promising.

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“…Patient satisfaction rates were reported to be 91.1%, and surgeon satisfaction rates were reported to be 88.6%, indicating that the modern use of fat grafting in facial reconstruction yields largely successful results for all involved. 26…”

Section: Application Of Fat Transfer In Facial Surgerymentioning

confidence: 99%

Safety and Regulation of Fat Grafting

Raj

Abu‐Ghname

Davis

et al. 2020

Seminars in Plastic Surgery

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Today, fat grafting has wide applicability across plastic surgery disciplines, including both aesthetic and reconstructive procedures. However, much controversy has surrounded adipose tissue transfer throughout the 20th century, necessitating extensive research to improve the fat grafting process and to better understand its associated complications and benefits. Initial concerns included the technical difficulties of properly handling and processing adipose to ensure adequate outcomes. As these issues were addressed, more modern concerns were raised by the U.S Food and Drug Administration and the general scientific community regarding the oncological potential of adipose tissue and its potential interference with breast cancer screenings. Today, many formalized clinical studies have evidenced the safety of fat grafting, allowing the procedure to gain widespread popularity and opening avenues for future applications.

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Efficacy and Safety of Autologous Fat Transfer in Facial Reconstructive Surgery

Cited by 67 publications

References 57 publications

Fat Grafting for Facial Contouring

Fat Grafting for Facial Contouring

The Development of Facial Lipofilling from a Historical Point of View

Safety and Regulation of Fat Grafting

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