Efficacy and Safety of Azithromycin 1.5% Eye Drops for Purulent Bacterial Conjunctivitis in Pediatric Patients

Bremond-Gignac, Dominique; Mariani‐Kurkdjian, Patricia; Béresniak, Ariel; Fekih, Lamia El; Bhagat, Yasmin; Pouliquen, P; Delval, L.; Goldschmidt, Pablo; Bingen, Edouard; Cochereau, Isabelle

doi:10.1097/inf.0b013e3181b99fa2

Cited by 32 publications

(25 citation statements)

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“…However, the bacteriological profile for patients in this study is similar to the one determined in the paediatric subgroup of an earlier large randomised controlled study17 20 and consistent with the causative microorganisms usually found in the literature for acute conjunctivitis in young children21–23. Haemophilus influenzae was the most frequently isolated pathogen, probably owing to the high incidence of associated acute otitis media in children with bacterial conjunctivitis (reported in 20–73% of cases), as this bacteria is the predominant pathogen responsible for the conjunctivitis otitis syndrome24–26.…”

Section: Discussionsupporting

confidence: 88%

“…When compared with tobramycin, efficacy of azithromycin was found to be significantly superior on D3 and non-inferior on D7. The clinical cure rates obtained for both antibiotics are very similar to those of previous studies, that is, 48% on D3 and 80% on D9 in azithromycin-treated children compared with 27% and 82% in tobramycin-treated children (6 years old on average)17 20.…”

Section: Discussionsupporting

confidence: 85%

“…Patients were mainly recruited in hospital centres where usually only very young children are seen for treatment of bacterial conjunctivitis. This enabled recruitment of a large proportion (>50%) of patients younger than 24 months old compared with other studies that mostly involved children in an older age range9 13 14 20 21.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy and safety of azithromycin 1.5% eye drops in paediatric population with purulent bacterial conjunctivitis

et al. 2014

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ObjectiveTo determine the efficacy and safety of azithromycin 1.5% eye drops in a paediatric population with purulent bacterial conjunctivitis.Patients and methodsThis was a multicentre, international, randomised, investigator-masked study in 286 children with purulent discharge and bulbar conjunctival injection. Patients received either azithromycin 1.5% eye drops (twice daily for 3 days) or tobramycin 0.3% eye drops (every 2 h for 2 days, then four times daily for 5 days). Clinical signs were evaluated on day (D) 0, 3 and 7, and cultures on D0 and D7. The primary variable was the clinical cure (absence of bulbar conjunctival injection and discharge) on D3 in the worse eye for patients with positive cultures on D0.Results286 patients (mean age 3.2 years; range 1 day–17 years) were included; 203 had positive cultures on D0. Azithromycin was superior to tobramycin in clinical cure rate on D3 (47.1% vs 28.7%, p=0.013) and was non-inferior to tobramycin on D7 (89.2% vs 78.2%, respectively). Azithromycin treatment eradicated causative pathogens, including resistant species, with a similar resolution rate to tobramycin (89.8% vs 87.2%, respectively). These results were confirmed in a subgroup of patients younger than 24 months old.ConclusionsAzithromycin 1.5% eye drops provided a more rapid clinical cure than tobramycin 0.3% eye drops in the treatment of purulent bacterial conjunctivitis in children, with a more convenient twice-a-day dosing regimen.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 85%

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Efficacy and safety of azithromycin 1.5% eye drops in paediatric population with purulent bacterial conjunctivitis

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“…Clinical trials demonstrated superior bacteriological cure with azithromycin treatment compared with treatment with tobramycin [39,40]. Fusidic acid is frequently prescribed by general practitioners.…”

Section: Bacterial Conjunctivitismentioning

confidence: 99%

Conjunctivitis: Systematic Approach to Diagnosis and Therapy

Thanathanee

O’Brien

2011

Curr Infect Dis Rep

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Conjunctivitis is a common problem in primary health care. Inflammation of the conjunctiva may result from infection or noninfectious causes. Microbial conjunctivitis may be caused by bacteria, viruses, or parasites. Although usually a benign, self-limited disease in healthy individuals, serious complications (eg, keratitis) may be sight-threatening. Accurate diagnosis and specific treatment of conjunctivitis remain challenging. History taking and physical examination are occasionally insufficient for correct diagnosis, thus laboratory testing may play a vital role in identification of specific pathogen(s). However, diagnostic testing has several limitations, including time-consuming methods, increased cost, and requirement for expertise in performance and interpretation. Treatment with empirical topical antibiotics for suspected infectious conjunctivitis is controversial. Although antibiotic treatment can diminish risk of adverse events and shorten the course of disease, drug resistance, toxicity, and expense are important considerations in management of acute infectious conjunctivitis.

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“…Treatment is requested, because it provides eradication of the bacteria and more rapid clinical improvement, decreases the rate of reinfection, prevents the invasion of infection, provides relief of the sypmtoms, shortens the disease time and decreases the risk of development of complications which threaten vision (28,(30)(31)(32)(33)(34). Ophtalmic antibiotics which are administered for a shorter period and with simpler doses increase the efficiency of treatment (35).…”

Section: Acute Bacterial Conjunctivitismentioning

confidence: 99%

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2012

Tpa

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Review Sum maryPediatric conjunctivitis is a common condition in childhood. It has often benign etiology and a self-limited course. Conjunctivitis may occur due to infectious and non infectious causes. Infectious causes include bacterial and viral conjunctivitis; noninfectious causes include allergic and chemical conjunctivitis. The diagnosis should be done according to clinical symptoms and findings. Also the treatment should be applied according to causes. In this review; the etiology, diagnosis, course and treatment of pediatric conjunctivitis will be described. (Turk Arch Ped 2012; 47: 237-243)

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Efficacy and Safety of Azithromycin 1.5% Eye Drops for Purulent Bacterial Conjunctivitis in Pediatric Patients

Abstract: Azithromycin 1.5% eye drops leads to a rapid clinical and microbiological cure.

Cited by 32 publications

References 23 publications

Efficacy and safety of azithromycin 1.5% eye drops in paediatric population with purulent bacterial conjunctivitis

Efficacy and safety of azithromycin 1.5% eye drops in paediatric population with purulent bacterial conjunctivitis

Conjunctivitis: Systematic Approach to Diagnosis and Therapy

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