Efficacy and Safety of Botulinum Toxin Type A for Treatment of Glabellar Lines: A Network Meta-Analysis of Randomized Controlled Trials

Li, Xue; Sui, Changlin; Xia, Xiujuan; Chen, Xianjin

doi:10.1007/s00266-022-03018-y

Cited by 8 publications

(8 citation statements)

References 35 publications

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“…These results are consistent with reported responder rates of other marketed BoNT/A products based on similar pivotal study designs and end point measures. 5,[21][22][23][24] Letibotulinumtox-inA was generally well-tolerated, with headache the only related TEAE occurring in greater than 1% of subjects in the treatment group.…”

Section: Discussionmentioning

confidence: 99%

LetibotulinumtoxinA Attenuates the Psychological Burden of Glabellar Lines and Is Associated With High Subject Satisfaction in Phase 3 Clinical Trials

Cox,

Kaufman-Janette,

Cohen

et al. 2024

Dermatol Surg

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BACKGROUND Hyperfunctional glabellar frown lines can transmit facial miscues that adversely affect emotional communication, increase perceptions of age, and diminish self-esteem. OBJECTIVE To evaluate the efficacy of letibotulinumtoxinA in mitigating the negative psychological impact associated with moderate to severe glabellar lines and to assess subject satisfaction with treatment outcome in the BLESS phase 3 clinical trials. MATERIALS AND METHODS Baseline and posttreatment assessments were made using validated subject-administered instruments: Modified Skindex-16 Glabellar Line Quality of Life (GL-QoL) Scale, Facial Assessment and Cosmetic Evaluation Questionnaire (FACE-Q) Appraisal of Lines Between Eyebrows Scale, FACE-Q Age Appraisal Visual Analog Scale, and FACE-Q Satisfaction with Outcome Scale. An integrated analysis using pooled BLESS data was conducted on these secondary end points. RESULTS Among enrolled and treated subjects (N = 1,272), 85.5% had moderate to severe psychological impact at baseline. LetibotulinumtoxinA subjects experienced significant improvements compared with placebo on all measures. Mean improvement to Week 4 for the Modified Skindex-16 GL-QoL Scale overall score was −33.84 for letibotulinumtoxinA subjects compared with −1.37 for placebo subjects (p < .001). Attenuation of psychological burden was highly correlated with improvement in glabellar line severity (p < .0001). CONCLUSION LetibotulinumtoxinA significantly improved the psychosocial burden associated with glabellar lines across all trials. Treated subjects experienced improved quality of life, younger perceived age, and satisfaction with treatment outcome.

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Section: Discussionmentioning

confidence: 99%

LetibotulinumtoxinA Attenuates the Psychological Burden of Glabellar Lines and Is Associated With High Subject Satisfaction in Phase 3 Clinical Trials

Cox,

Kaufman-Janette,

Cohen

et al. 2024

Dermatol Surg

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“…Face wrinkles are the most obvious sign of aging, and therefore a wide range of cosmetic modalities have been developed to treat facial rhytides. Among these, glabellar lines are perceived as obvious sign of aging and individuals with glabellar lines often seek treatment because these wrinkles can deliver erroneous impression of being annoyed or angry [11]. Currently, there are various methods used to treat these wrinkles, including surgery, botulinum toxin A (BXTA), and implants [11,12].…”

Section: Discussionmentioning

confidence: 99%

“…Among these, glabellar lines are perceived as obvious sign of aging and individuals with glabellar lines often seek treatment because these wrinkles can deliver erroneous impression of being annoyed or angry [11]. Currently, there are various methods used to treat these wrinkles, including surgery, botulinum toxin A (BXTA), and implants [11,12]. Accumulating evidence based on clinical trials has indicated that BXTA is an effective and safe aesthetic treatment method for glabellar lines [11,13].…”

Section: Discussionmentioning

confidence: 99%

“…Currently, there are various methods used to treat these wrinkles, including surgery, botulinum toxin A (BXTA), and implants [11,12]. Accumulating evidence based on clinical trials has indicated that BXTA is an effective and safe aesthetic treatment method for glabellar lines [11,13]. However, BXTA injection on glabellar lines could result in several side effects such as ecchymosis, infection, transient headache, allergic reaction, blepharoptosis, and periorbital edema [14].…”

Section: Discussionmentioning

confidence: 99%

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Glabellar wrinkle improvement after forehead and periorbital micro-focused ultrasound treatment in Republic of Korea: a case report

et al. 2023

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Microfocused ultrasound (MFU) is a non-invasive treatment modality for skin tightening that induces multiple tiny thermal injury zones at focused areas resulting in neocollagenesis and skin lifting. This paper presents a 38-year-old female treated with MFU in the forehead and periorbital area, showing significant improvement in glabellar wrinkles, eyebrow lift, and skin regeneration. The pain during the MFU treatment was minimal, and the effects of the improvement in glabellar lines were maintained for eight weeks. The results suggest that MFU could be an effective treatment option for glabellar lines.

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“…The use of botulinum toxin in dermatology, plastic surgery, and aesthetic medicine has increased rapidly over the years, and it is the most common cosmetic procedure performed worldwide [ 1 , 2 ]. Interestingly, the introduction in the 1990s of a beauty model based on a youthful appearance and the absence of wrinkles on the face has facilitated the rapid growth of botulinum toxin injections in both men and women [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Real-World, Retrospective, Multicenter, Observational Study on the Use of the First Liquid AbobotulinumtoxinA in Italy

Di Gregorio,

Tretti-Clementoni,

Belmontesi

et al. 2023

Dermatol Ther (Heidelb)

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Introduction Randomized controlled trials (RCTs) suggested that liquid formulation of botulinum toxin type A (aboBoNT-A) is safe and effective, but data confirming these characteristics in a real-life heterogenous set of patients are currently lacking. This study aimed to assess the efficacy and safety of the ready-to-use aboBoNT-A solution in adults with moderate-to-severe glabellar wrinkles. Methods In this real-life, multicenter, retrospective, observational study, healthy adults were treated at baseline only with aboBoNT-A solution on the glabellar area and followed up for 24 weeks. Re-treatment after 20–24 weeks could also be combined with other aesthetic procedures. Family history of immune-mediated inflammatory diseases (IMIDs) was not an exclusion criterion. Patient-reported outcomes (patient’s satisfaction and injection-related pain) and physician-reported outcomes (Physician Global Assessment, PGA) were collected. Results Of the 542 patients enrolled in the study, 38 had IMID family history. Injection-related pain was reported in 128 (23.62%) as mild (pain VAS = 1.34 ± 0.87) mainly by non-botulinum toxin treatment-naïve women under 50 years of age. At 48 h, physicians rated the clinical result as “improved” in 64% of patients, conversely 264 patients (48.71%) self-evaluated as “satisfied”/”very satisfied”. At 4 weeks a touch-up (< 10 units) was performed in 11 (2.03%) patients and 98.2% were “highly satisfied”. Re-treatment was performed in 330 (61.45%) patients, mainly botulinum-experienced, at 20 weeks and in 207 (38.55%), mainly botulinum naïve, at 24 weeks. A total of 403 (74.35%) patients were re-treated with the three-point technique and 201 (37.08%) also received hyaluronic acid filler in the lower central face and middle third. There were no cases of de novo IMIDs. Conclusions Real-world data confirmed that aboBoNT-A is a fast, efficient, durable, reproducible, and easy-to-use drug which is also well tolerated in patients with family history of IMID.

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Efficacy and Safety of Botulinum Toxin Type A for Treatment of Glabellar Lines: A Network Meta-Analysis of Randomized Controlled Trials

Cited by 8 publications

References 35 publications

LetibotulinumtoxinA Attenuates the Psychological Burden of Glabellar Lines and Is Associated With High Subject Satisfaction in Phase 3 Clinical Trials

LetibotulinumtoxinA Attenuates the Psychological Burden of Glabellar Lines and Is Associated With High Subject Satisfaction in Phase 3 Clinical Trials

Glabellar wrinkle improvement after forehead and periorbital micro-focused ultrasound treatment in Republic of Korea: a case report

Real-World, Retrospective, Multicenter, Observational Study on the Use of the First Liquid AbobotulinumtoxinA in Italy

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