Efficacy and safety of bromelain: A systematic review and meta-analysis

Leelakanok, Nattawut; Petchsomrit, Arpa; Janurai, Thitapa; Saechan, Charinrat; Sunsandee, Niti

doi:10.1177/02601060231173732

Cited by 3 publications

(1 citation statement)

References 66 publications

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“…Worldwide, bromelain is recognized as a safe and effective therapeutic agent, used by individuals to treat ailments such as arthritis, sinusitis, bronchitis and inflammation [2].…”

Section: Introductionmentioning

confidence: 99%

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Consorti,

Monarchi,

Paglianiti

et al. 2024

JCM

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Background: Bromelain and coumarins are recognized as safe and effective therapeutic agents, used by individuals to treat ailments such as postoperative edema, inflammation and other diseases. Bromelain has been proven to be well absorbed by the body after oral administration, and it has no major side effects even after prolonged use. The purpose of this study is to evaluate the effectiveness of bromelain and other nutraceuticals in reducing post-surgical swelling, pain and the need of anti-inflammatory drugs in maxillofacial post-traumatic surgery. Methods: This prospective open-label study was conducted on patients undergoing surgery for trauma of the maxillofacial area. One hundred patients were selected and divided into two groups: one group who underwent therapy with bromelain, Aesculus hippocastanum and Melilotus officinalis and a control group that was not given the drug in postoperative therapy. Results: Patients in the experimental group showed a reduction of edema in the first and second postoperative weeks, a faster complete reduction of facial edema and a lower reduction in maximum mouth opening and needed less anti-inflammatory therapy to control pain. Conclusions: These findings seem to provide evidence that Brovas® may be effective in improving postoperative edema outcomes in patients undergoing surgical treatment of facial fractures.

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“…Worldwide, bromelain is recognized as a safe and effective therapeutic agent, used by individuals to treat ailments such as arthritis, sinusitis, bronchitis and inflammation [2].…”

Section: Introductionmentioning

confidence: 99%

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Consorti,

Monarchi,

Paglianiti

et al. 2024

JCM

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Enzymatic debridement with bromelain and development of bacteremia in burn injuries: A retrospective cohort study

Deplazes,

Hofmaenner,

Scheier

et al. 2024

Burns

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Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism

Quagliariello,

Canale,

Bisceglia

et al. 2024

Biomedicines

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Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in the world. The emerging field of cardio-oncology described several shared risk factors that predispose patients to both cardiovascular disease and cancer. Post-acute COVID-19 syndrome is a chronic condition that occurs in many patients who have experienced a SARS-CoV-2 infection, mainly based on chronic fatigue, sedentary lifestyle, cramps, breathing difficulties, and reduced lung performance. Post-acute COVID-19 exposes patients to increased visceral adiposity, insulin resistance, myosteatosis, and white adipose tissue content (surrounded by M1 macrophages and characterized by a Th1/Th17 phenotype), which increases the risk of cardiovascular mortality and cancer recurrence. In this review, the main metabolic affections of post-acute COVID-19 syndrome in cancer patients at low and high risk of cardiomyopathies will be summarized. Furthermore, several non-pharmacological strategies aimed at reducing atherosclerotic and cardiac risk will be provided, especially through anti-inflammatory nutrition with a low insulin and glycemic index, appropriate physical activity, and immune-modulating bioactivities able to reduce visceral obesity and myosteatosis, improving insulin-related signaling and myocardial metabolism.

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Efficacy and safety of bromelain: A systematic review and meta-analysis

Cited by 3 publications

References 66 publications

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Enzymatic debridement with bromelain and development of bacteremia in burn injuries: A retrospective cohort study

Addressing Post-Acute COVID-19 Syndrome in Cancer Patients, from Visceral Obesity and Myosteatosis to Systemic Inflammation: Implications in Cardio-Onco-Metabolism

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