Efficacy and Safety of “Bushen Huoxue Therapy”-Based Combined Chinese and Western Medicine Treatment for Diabetic Kidney Disease: an Updated Meta-Analysis of 2105 Patients

Abstract

Background. Diabetic kidney disease (DKD) is the most important cause of the end-stage renal disease (ESRD) and the main cause of renal replacement therapy. Excessive inflammatory response and renal fibrosis are the keys to the development of this disease, and the conventional Western medical treatment is difficult to achieve and obtain long-term stable clinical results in all patients with DKD. Many studies have shown that Chinese medicine as a complementary and alternative medicine may be another therapeutic option to mitigate the progression of DKD to ESRD. In recent years, many doctors have used the Bushen Huoxue therapy to assist Western medicine in the treatment of the disease and have achieved certain clinical effects. However, most of the current studies are small sample studies, and there is no evidence-based confirmation. Objective. To systematically evaluate the efficacy and safety of the Bushen Huoxue therapy combined with conventional Western medicine in the treatment of DKD. Methods. A comprehensive search of literature databases such as CNKI, Wanfang, Pubmed, and Cochrane Library was conducted. The screening condition was that the control group was treated with conventional Western medicine and the experimental group was treated with Bushen Huoxue therapy’s RCT on top of the control group, and the RCTs were published from January 2011 to October 2021. The Cochrane risk bias assessment tool was used for literature quality evaluation, and RevMan 5.3 software was used for statistical analysis. Results. A total of 23 RCTs were finally included, with a total of 2,105 patients. Meta-analysis results show that the experimental group can effectively improve the clinical efficacy (RR = 1.28, 95% CI (1.22, 1.34), P < 0.01 ), significantly reduce Crea (SMD = −0.45, 95% CI (−0.57, −0.33), P < 0.01 ), 24 h UTP (SMD = −0.57, 95% CI (−0.69, −0.45), P < 0.01 ), BUN (SMD = −0.36, 95%CI (−0.48, −0.24), P < 0.01 ), UAER (SMD = −1.58, 95% CI (−1.78, −1.37), P < 0.01 ), and blood sugar, and have certain medication safety (RR = 0.00, 95% CI (−0.03, 0.03), P = 0.87 ). Conclusions. Chinese medicine based on the Bushen Huoxue therapy has a good clinical effect in the treatment of diabetic kidney disease and has certain safety. However, due to the limitation of the quality and quantity of the included literature, the above conclusion still needs more rational experiments to further verify.

Clinical Characteristics and Chinese Medicine Therapy of Chronic Kidney Disease Combined with Cardiovascular Disease

“…[5] Several meta-analyses of the treatment of patients with CKD and CM have shown that CM has good clinical efficacy. [26,27] Due to the complex pathophysiological process of CKD-CVD, the above-mentioned treatments to control traditional risk factors have not achieved the expected efficacy in reducing CVD mortality in patients with CKD. As shown in Table 1, several clinical trials have been conducted to explore the effectiveness of CM or a combination of Chinese and Western medicines in improving the clinical outcomes of CKD or CVD patients.…”

Xuebijing injection combined with alprostadil in the treatment of diabetic nephropathy: A PRISMA-compliant systematic review and meta-analysis

“…[ 4 ] In recent years, Traditional Chinese Medicine has gained good curative effects in reducing DN symptoms, assisting in stable blood pressure reduction, glucose and lipid reduction, strengthening renal function, and delaying the progress of DN. [ 5 , 6 ] Xuebijing injection (XBJI) is a kind of traditional Chinese medicine injection, which is extracted from the effective components of traditional Chinese medicine such as Honghua, Chishao, Chuanxiong, Danshen, Danggui. It has the effects of promoting blood circulation and removing blood stasis, clearing heat and detoxification, strengthening health and tonifying deficiency.…”

Mechanistic Study of Schisandra chinensis Fruit Mixture Based on Network Pharmacology, Molecular Docking and Experimental Validation to Improve the Inflammatory Response of DKD Through AGEs/RAGE Signaling Pathway

“…[12][13][14] Our previous meta-analysis based on 2105 DKD patients demonstrated that TCM combined with Western medicine significantly reduced renal damage indicators and blood glucose levels and had the same safety as conventional Western therapy. 15 Schisandra chinensis fruit Mixture (SM) is a Chinese herbal formula for DKD that consists of three herbs: Schisandra chinensis fruit ("Wuweizi" in Chinese, WWZ), Rhizoma chuanxiong ("Chuanxiong" in Chinese, CX) and Oyster shells ("Muli" in Chinese, ML). Our previous study showed that WWZ alcohol extract was effective in preventing DKD-induced EMT 16 and demonstrated that SM may treat DKD via the PI3K/AKT pathway, 17 but the exact mechanism remains to be further investigated.…”