Efficacy and safety of cholecalciferol-augmented anti-tuberculosis therapy for treatment of naïve patients with pulmonary tuberculosis: A randomized, controlled, clinical study

Hasanain, Ahmad Farooq Alsayed; Zayed, Ali Abdel-Azeem Hasan; Abd-ellatief, Rasha B.; Nafee, Amany Mohamed Adawi

doi:10.1016/j.ijtb.2018.06.004

Cited by 5 publications

(3 citation statements)

References 30 publications

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“… Efficacy of vitamin D supplements in treatment of acute respiratory infections in a meta-analysis of randomized controlled trials ( n = 18) [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. RR, relative risk; CI, confidence interval.…”

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Previous randomized controlled trials (RCTs) have shown inconsistent findings regarding the efficacy of vitamin D supplements in the treatment of ARIs [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. Several RCTs reported that vitamin D supplements had a beneficial effect [ 14 , 19 , 21 , 28 , 29 , 30 ], while others reported no effect [ 15 , 16 , 17 , 18 , 20 , 22 , 23 , 24 , 25 , 26 , 27 , 31 ]. Several meta-analyses have been published on the efficacy of vitamin D supplements in the treatment of pulmonary tuberculosis (TB), pneumonia, and COVID-19 [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Vitamin D Supplements in Treatment of Acute Respiratory Infection: A Meta-Analysis for Randomized Controlled Trials

2022

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Background: Recent randomized controlled trials (RCTs) have reported inconsistent findings regarding the efficacy of vitamin D supplementation in the treatment of acute respiratory infections (ARIs). This study aimed to investigate the efficacy of vitamin D supplementation in the treatment of ARIs using a meta-analysis of RCTs. Methods: PubMed, EMBASE, and the Cochrane Library were searched for relevant articles in June 2021. Two of the authors independently assessed the eligibility of the trials. Results: Out of 390 articles retrieved from the databases, we included 18 RCTs, which involved 3648 participants, with 1838 in an intervention group and 1810 in a control group in the final analysis. In the meta-analysis of all the trials, vitamin D supplements had a beneficial effect in the treatment of ARIs (relative risk (RR) = 1.07; 95% confidence interval (CI), 1.01–1.13; I2 = 66.9%). Publication bias was observed in the funnel plot. In the subgroup meta-analysis of high-quality RCTs, no significant efficacy of vitamin D supplements was found (RR = 1.02; 95% CI, 0.98–1.06; I2 = 24.0%). Although statistically significant changes of 7% in the treatment effects were observed, they are not considered as clinically substantial ones. Conclusions: The current meta-analysis suggests that vitamin D supplements are not clinically effective in the treatment of ARIs.

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