Efficacy and safety of Choudongning capsule (CDN)in children with Tourette's syndrome of spleen deficiency and phlegm accumulation

Yang, Na; Ma, Rong; Hu, Si-Yuan; Liu, Hong; Hu, Yan; Xixiong, Xiang; Wang, Xuefeng; Chen, Yinbo; Chen, Yu‐Yan; Jiao, Fuyong; Ding, Ying; Huang, Hao; Wang, Ling-Di

doi:10.4268/cjcmm20161627

Cited by 2 publications

(1 citation statement)

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“…Ningdong granule (NDG) is a combination of plant, animal, and placental products thought to modulate the D2 receptor pathway and has been shown to be well-tolerated and effective at reducing tics compared to placebo [ 77 •]. Choudongning (CDN) capsule has shown promise in several double-blind, placebo-controlled studies [ 113 •, 114 , 115 ]. 5-Ling granule (5-LGr) contains 11 different herbs and has shown comparable efficacy to tiapride with better tolerability [ 116 ].…”

Section: Pharmacologic Interventionsmentioning

confidence: 99%

Tourette Syndrome Treatment Updates: a Review and Discussion of the Current and Upcoming Literature

Frey

Malaty

2022

Curr Neurol Neurosci Rep

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Purpose of Review This study aims to examine the treatments currently available for Tourette syndrome (TS) and to discuss evolving therapies, spanning behavioral, pharmacologic, complementary and alternative medicine, and neuromodulation approaches. Recent Findings Behavioral therapies have undergone several modifications to improve accessibility, including transitioning to a virtual format which is particularly important in the current pandemic. There are several recent or ongoing pharmacologic studies that have shown promise including the selective D1 receptor antagonist ecopipam and various cannabinoid compounds. Adaptive DBS may enable the physiologic markers of tics to determine stimulation parameters and improve tic outcomes related to neuromodulation. Summary In recent years, there has been a wealth of research across multiple treatment domains in the TS field. This review highlights exciting and new potential options for the future treatment of patients with TS.

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Section: Pharmacologic Interventionsmentioning

confidence: 99%

Tourette Syndrome Treatment Updates: a Review and Discussion of the Current and Upcoming Literature

Frey

Malaty

2022

Curr Neurol Neurosci Rep

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Traditional Chinese Medicine Strategy for Patients with Tourette Syndrome Based on Clinical Efficacy and Safety: A Meta-Analysis of 47 Randomized Controlled Trials

Wang

Qin

Xie

et al. 2021

BioMed Research International

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Objective. Although increasing evidence reveals the efficacy of traditional Chinese medicine (TCM) and its safety on Tourette Syndrome (TS) patients, whether TCM is indeed improving TS remains unclear. The purpose of the current study is to perform a meta-analysis to evaluate the efficacy and safety of TCM on treating TS patients. Method. An elaborate search strategy was conducted based on several databases including Medline, Embase, Cochrane, Web of Science, CINAHL, CBM, VIP, CNKI, and Wanfang Data in order to identify the relevant randomized controlled trials (RCTs) from their inception to as late as May 1st, 2020. General information and data needing analysis were extracted simultaneously for the necessity of various analyses such as descriptive analysis and metaquantitative analysis. Results. Forty-seven trials with 5437 TS patients in total were eventually included according to our criteria. All trials were conducted in China, and the publication years ranged from 2004 to 2017. In terms of clinical efficacy, clinical symptoms of patients with TCM were more likely to be improved compared with the control group (odds ratio, OR = − 1.29 , 95% confidence interval, CI: -2.54 to -0.06, I 2 = 0.00 % ). As to the outcome of recurrence rate, the pooled results revealed that the TCM group was more inclined to stabilize the recurrence ( OR = 0.44 , 95% CI: 0.24 to 0.78, I 2 = 0.00 % ). Similar results were observed in adverse reaction ( OR = 0.32 , 95% CI: 0.24 to 0.43, I 2 = 32.90 % ). Conclusion. The results of our study recommend applying TCM to treat TS patients for better efficacy and safety. Results need to be interpreted cautiously due to certain limitations in our study.

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Efficacy and safety of Choudongning capsule (CDN)in children with Tourette's syndrome of spleen deficiency and phlegm accumulation

Cited by 2 publications

References 0 publications

Tourette Syndrome Treatment Updates: a Review and Discussion of the Current and Upcoming Literature

Tourette Syndrome Treatment Updates: a Review and Discussion of the Current and Upcoming Literature

Traditional Chinese Medicine Strategy for Patients with Tourette Syndrome Based on Clinical Efficacy and Safety: A Meta-Analysis of 47 Randomized Controlled Trials

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