2024
DOI: 10.22146/ijpther.9801
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Efficacy and safety of clozapine combination with different antipsychotics in schizophrenia: a systematic review

Maria Sri Ayu Mustikawati,
Bambang Hastha Yoga Legowo Budiman,
Zullies Ikawati

Abstract: Schizophrenia is a severe and chronic mental disorder, where antipsychotics are used as the main therapy. Antipsychotics are commonly used in combination, especially in refractory patients. Clozapine is one of antipsychotics that is often used in combination with other antipsychotic to achieve more effective treatment. However, the effectiveness and safety of the clozapine combination are still inconclusive. This review aimed to evaluate the efficacy and safety evidence of clozapine combination therapy with di… Show more

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