Efficacy and Safety of Continuous Infusion of Fentanyl for Pain Control in Preterm Newborns on Mechanical Ventilation

Effects of Different Doses of Fentanyl on the Sedation of Infants Under Mechanical Ventilation; A Randomized Clinical Trial

“…The authors concluded that fentanyl infusion did not reduce prolonged pain; however, it was effective on acute pain. 14 In another similar study, Roth et al evaluated the analgesic and sedative effects of fentanyl on infants undergoing mechanical ventilation for RDS. Infants in the intervention group received a fentanyl infusion at a mean…”

Comparison of Fentanyl and Midazolam for the Sedation of Infants Under Mechanical Ventilation; A Randomized Clinical Trial

“…In their study, the mean length of stay was 10 days for the fentanyl group and 7 days for the placebo group. 10 Zhu et al conducted a systematic review and metaanalysis in which they evaluated the effect of remifentanil on the duration of mechanical ventilation in comparison with other opioids such as fentanyl and morphine. They concluded that remifentanil reduces the duration of ventilation as well as the ICU length of stay (LOS).…”

Manejo de la sedación y la analgesia en unidades de cuidados intensivos neonatales españolas

“…Additional multivariable analyses (propensity score matching, stratifi cation, and regression adjustment) and analyses in infants in whom these medications were started early after initiation of TV substantiated this fi nding, consistent with the fi ndings from randomised trials of drugrelated respiratory depression in neonates. [45][46][47] Propensity score matching allowed the elimination of diff erences in baseline characteristics between infants who received O-SH-GA and those who did not. Potential confounders such as being on TV at NICU admission were balanced with this approach.…”