2014
DOI: 10.1200/jco.2014.32.15_suppl.8001
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Efficacy and safety of crizotinib in patients with advanced c-MET-amplified non-small cell lung cancer (NSCLC).

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Cited by 233 publications
(202 citation statements)
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“…De novo MET amplification has been associated with primary resistance to EGFR TKIs (43). Therapeutic targeting of MET may be an effective strategy in MET amplified tumors (44,45). Results from a phase 2 study of cabozantinib (an oral MET/VEGFR2/RET inhibitor) in patients with EGFR mutant lung cancer and progression on EGFR TKI resulted in 3 partial responses out of 35 patients treated (46).…”
Section: Therapeutic Strategies Targeting Alternate Pathwaysmentioning
confidence: 99%
“…De novo MET amplification has been associated with primary resistance to EGFR TKIs (43). Therapeutic targeting of MET may be an effective strategy in MET amplified tumors (44,45). Results from a phase 2 study of cabozantinib (an oral MET/VEGFR2/RET inhibitor) in patients with EGFR mutant lung cancer and progression on EGFR TKI resulted in 3 partial responses out of 35 patients treated (46).…”
Section: Therapeutic Strategies Targeting Alternate Pathwaysmentioning
confidence: 99%
“…Furthermore, there are examples of Met driven tumors with nice responses to anti-Met therapies. Met amplification seems to be up to date, the best predictor of response to Met inhibitors [29-31]. However, evaluation of copy number changes by FISH is challenging in SCLC due to the typical crushing phenomenon of these tumors and was not feasible in our hands[32].…”
Section: Discussionmentioning
confidence: 99%
“…All patients who responded had a MET/CEP7 ratio >2.2. [41] Final data from this study is not yet available; however, crizotinib is a promising therapeutic option for some patients with MET amplified NSCLC and there may be a role for utilizing the MET/CEP7 ratio as a biomarker to predict response. Another study also demonstrated efficacy of MET inhibitors crizotinib and cabozantinib in four patients with MET exon 14 splice site mutations.…”
Section: Metmentioning
confidence: 95%