Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial

Tang, Wuyinuo; Liang, Jingtao; Ju, Wu; Liu, Li; Lu, Ming-Zhang; He, Xiao-Yan; Wu, Lijuan; Jiang, Haolin; Wang, Fei; Meng, Xiao; Li, Shun-Pin

doi:10.1155/2021/4354054

Cited by 11 publications

(9 citation statements)

References 44 publications

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“…Escitalopram was previously the mainstay for the treatment of depression, which is beneficial to improve the symptoms of depression. And alternative medicine (CAM) is often used in order to alleviate these problems [ 5 – 9 ]. The compound lactic acid bacteria capsule is a drug for the treatment of intestinal flora disorders.…”

Section: Introductionmentioning

confidence: 99%

Effect of Compound Lactic Acid Bacteria Capsules on the Small Intestinal Bacterial Overgrowth in Patients with Depression and Diabetes: A Blinded Randomized Controlled Clinical Trial

et al. 2022

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Objective. The objective is to explore the clinical effect of compound lactic acid bacteria capsules on the small intestinal bacterial overgrowth (SIBO) in patients with depression and diabetes. Methods. From January 2020 to January 2021, 60 SIBO patients with depression and diabetes in our hospital were selected and randomized into observation group (compound lactic acid bacteria capsules combined with escitalopram) and control group (Escitalopram) according to the odd and even numbers, 30 cases in each group. The two groups were compared in terms of SAS, SDS, levels of inflammatory factors, immune function, fasting plasma glucose (FPG), treatment effect, and the incidence of adverse reactions. Results. Both self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores in both groups showed a decline after treatment ( P < 0.05 ), and the reduction was more significant in the observation group ( t = 10.047 , 17.862, all P ≤ 0.001 ). Both IL-2 and TNF-α in both groups showed a decline after treatment ( P < 0.05 ), and the reduction was more greater in the observation group in relative to the control group ( P < 0.05 ). CD3+ and CD+4 in both groups showed an increase after treatment ( P < 0.05 ), and the increase was more greater in the observation group as compared to the control group ( P < 0.05 ). After treatment, the FPG levels of patients in both groups showed a decline ( P < 0.05 ), and the reduction of FPG levels was more significant in the observation group than that in the control group ( t = 3.948 , P ≤ 0.001 ). The control group experienced a remarkably higher incidence of adverse reactions. Conclusion. The compound lactic acid bacteria capsule is a boon for SIBO patients with depression and diabetes. It can mitigate depression symptoms, improve immune function, reduce the level of inflammatory factors, and lower the FPG levels, along with fewer adverse reactions and robust effects.

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Section: Introductionmentioning

confidence: 99%

Effect of Compound Lactic Acid Bacteria Capsules on the Small Intestinal Bacterial Overgrowth in Patients with Depression and Diabetes: A Blinded Randomized Controlled Clinical Trial

et al. 2022

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“…In recent years, herbal compounds have been documented to trigger the generation of ROS, suppress the activation of inflammasomes, and exhibit anti-inflammatory and antifibrotic effects [ 51 ]. Clinical trials have shown that patients' lung function, quality of life, and exercise ability have significantly improved after treatment with traditional Chinese medicines [ 52 ].…”

Section: Treatment For Silicosismentioning

confidence: 99%

Early Identification, Accurate Diagnosis, and Treatment of Silicosis

Yang

et al. 2022

Canadian Respiratory Journal

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Silicosis is a global problem, and it has brought about great burdens to society and patients’ families. The etiology of silicosis is clear, preventable, and controllable, but the onset is hidden and the duration is long. Thus, it is difficult to diagnose it early and treat it effectively, leaving workers unaware of the consequences of dust exposure. As such, a lack of details in the work history and a slow progression of lung disease contribute to the deterioration of patients until silicosis has advanced to fibrosis. These issues are the key factors impeding the diagnosis and the treatment of silicosis. This article reviews the literature on the early identification, diagnosis, and treatment of silicosis as well as analyzes the difficulties in the diagnosis and the treatment of silicosis and discusses its direction of future development.

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“…This shows that tetrandrine combined with acetylcysteine can effectively improve the clinical treatment effect of silicosis and reduce the degree of inflammation in silicosis patients. Tang et al [ 7 ] also found that Dahuang Zhechong pills (DHZCP) could improve lung function, quality of life, and exercise ability in PF patients. The lung damage caused by particulate matter is related to the type and particle size.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of HIF-1α Attenuates Silica-Induced Pulmonary Fibrosis

Niu

et al. 2022

IJERPH

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Background: Excessive accumulation of extracellular matrix is a key feature of pulmonary fibrosis (PF), and myofibroblasts are the main producers of extracellular matrix. Fibroblasts are the major source of myofibroblasts, but the mechanisms of transdifferentiation are unclear. Methods: In vitro, transforming growth factor-β1 was used to induce NIH-3T3 cell transdifferentiation. DMOG was used to increase hypoxia-inducible factor-1α subunit (HIF-1α) expression. KC7F2 and siRNA decreased HIF-1α expression. In vivo, silica particles were used to induce PF in C57BL/6N mice, and KC7F2 was used to reduce HIF-1α expression in C57BL/6N mice. Western blot was used to detect the expression of collagen type 1 alpha 1(COL1A1), α-smooth muscle actin (α-SMA), SMAD family member (SAMD) 3, Phospho-SMAD3 (PSMAD3), and HIF-1α. PCR was used to detect the expression of COL1A1, α-SMA, and HIF-1α. Immunohistochemistry was used to detect the expression of COL1A1 and HIF-1α. Results: In vitro, compared to the control group, COL1A1, α-SMA, PSMAD3, and HIF-1α expression were elevated in the DMOG group, and COL1A1, α-SMA, PSMAD3, and HIF-1α expression were decreased in the KC7F2 group and siRNA group. Compared to the DMOG group, COL1A1, α-SMA, and PSMAD3 expression were decreased in the DMOG + SIS3 group. In vivo, compared to the saline group, COL1A1, α-SMA, PSMAD3, and HIF-1α expression were increased in the pulmonary tissue of C57BL/6N mice in the silica group. Compared to the silica group, COL1A1, α-SMA, PSMAD3, and HIF-1α expression and the degree of PF were decreased in the silica + KC7F2 group. Conclusion: Inhibition of HIF-1α reduced α-SMA, decreased COL1A1 expression, and attenuated the degree of PF in C57BL/6N mice. Therefore, HIF-1α may be a new target for the treatment of silica-induced PF.

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Efficacy and Safety of Dahuang Zhechong Pill in Silicosis: A Randomized Controlled Trial

Cited by 11 publications

References 44 publications

Effect of Compound Lactic Acid Bacteria Capsules on the Small Intestinal Bacterial Overgrowth in Patients with Depression and Diabetes: A Blinded Randomized Controlled Clinical Trial

Effect of Compound Lactic Acid Bacteria Capsules on the Small Intestinal Bacterial Overgrowth in Patients with Depression and Diabetes: A Blinded Randomized Controlled Clinical Trial

Early Identification, Accurate Diagnosis, and Treatment of Silicosis

Inhibition of HIF-1α Attenuates Silica-Induced Pulmonary Fibrosis

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