Efficacy and Safety of Dibufelon in Drug-Resistant Epilepsy

Иванова, Н. Е.; Kravtsova, Svetlana; Фадеева, Татьяна; Dengina, N. O.; Odintsova, G. V.

doi:10.56618/2071-2693_2023_15_1_24

Cited by 1 publication

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“…The targets are not only ion channels or neurotransmitters but also enzymes that metabolize neurotransmitters (GAD). Antiepileptic activity is achieved by changing the activity of neurons and disrupting the synchronization of neuronal circuits [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroinflammatory Dysfunction of the Blood–Brain Barrier and Basement Membrane Dysplasia Play a Role in the Development of Drug-Resistant Epilepsy

Zabrodskaya

Paramonova

Литовченко

et al. 2023

IJMS

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Drug-resistance epilepsy (DRE) is a key problem in neurology. It is possible that damage to the blood–brain barrier (BBB) may affect resistance in DRE. The aim of this work was to assess the damage and dysfunction in the BBB in the area of epileptic foci in patients with DRE under conditions of neuroinflammation. The changes to the BBB in temporal lobe epilepsy (by immunohistochemistry and transmission electron microscopy), levels of neuroinflammatory proteins, and cytokine levels in the blood (by multiplex analysis) were studied. Increased levels of vascular endothelial growth factor (VEGF) and growth-regulated protein (GRO), and decreased levels of epidermal growth factor (EGF) in plasma, combined with overexpression of the VEGF-A receptor by endotheliocytes were detected. Malformation-like growths of the basement membrane of the capillaries of the brain complicate the delivery of antiepileptic drugs (AEDs). Dysplasia of the basement membrane is the result of inadequate reparative processes in chronic inflammation. In conclusion, it should be noted that damage to the microcirculatory network of the brain should be considered one of the leading factors contributing to DRE.

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Section: Introductionmentioning

confidence: 99%