Efficacy and safety of direct oral anticoagulants in splanchnic vein thrombosis: a pooled analysis of literature studies

Portal Vein Thrombosis: State-of-the-Art Review

“…In patients with PVT without cirrhosis, data comparing DOAC with other anticoagulants are limited to observational studies; they generally favor the use of DOAC ( Table 3 ) [ 100 , 101 , 102 , 103 , 104 ].…”

“…Calcaterra et al performed a meta-analysis on 16 studies (648 patients) on SVT treated with DOACs. Recanalization was found in 60.3% (95% CI: 41.8–76.3%; I 2 = 84.9%; p < 0.001) and full recanalization in 51.7% (95% CI: 36.0–67.0%; I 2 = 87.4%; p < 0.001) [ 100 ]. Recurrent venous thromboembolism happened in 2.8% (95% CI: 1.4–5.9%; I 2 = 0%; p = 0.787) and death in 3.4% (95% CI: 1.6–7.3%; I 2 = 13.2%; p = 0.318) of patients [ 100 ].…”

“…Recanalization was found in 60.3% (95% CI: 41.8–76.3%; I 2 = 84.9%; p < 0.001) and full recanalization in 51.7% (95% CI: 36.0–67.0%; I 2 = 87.4%; p < 0.001) [ 100 ]. Recurrent venous thromboembolism happened in 2.8% (95% CI: 1.4–5.9%; I 2 = 0%; p = 0.787) and death in 3.4% (95% CI: 1.6–7.3%; I 2 = 13.2%; p = 0.318) of patients [ 100 ]. Major bleeding was reported by 5.8% (95% CI: 3.7–8.9%; I 2 = 29.2%; p = 0.125) of patients [ 100 ].…”

“…Recurrent venous thromboembolism happened in 2.8% (95% CI: 1.4–5.9%; I 2 = 0%; p = 0.787) and death in 3.4% (95% CI: 1.6–7.3%; I 2 = 13.2%; p = 0.318) of patients [ 100 ]. Major bleeding was reported by 5.8% (95% CI: 3.7–8.9%; I 2 = 29.2%; p = 0.125) of patients [ 100 ]. Increasing age and development of cancer affects the rate of recanalization [ 100 ], whereas cirrhosis was related to an increased rate of major bleeding and mortality [ 100 ].…”

“…Major bleeding was reported by 5.8% (95% CI: 3.7–8.9%; I 2 = 29.2%; p = 0.125) of patients [ 100 ]. Increasing age and development of cancer affects the rate of recanalization [ 100 ], whereas cirrhosis was related to an increased rate of major bleeding and mortality [ 100 ].…”