Efficacy and Safety of Elective Conversion From Sotrastaurin (STN) to Tacrolimus (TAC) or Mycophenolate (MPS) in Stable Kidney Transplant Recipients

Hannun, Pedro; Felipe, Cláudia Rosso; Ferreira, Alexandra; Sandes‐Freitas, Tainá Veras de; Cristelli, Marina Pontello; Aguiar, Wilson; Franco, Marcello; Campos, Érika F.; Lima, Maria Gerbase de; Tedesco‐Silva, Hélio; Medina-Pestana, J.O.

doi:10.1097/ftd.0000000000000292

Therapeutic Drug Monitoring

2016

DOI: 10.1097/ftd.0000000000000292

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Efficacy and Safety of Elective Conversion From Sotrastaurin (STN) to Tacrolimus (TAC) or Mycophenolate (MPS) in Stable Kidney Transplant Recipients

Pedro Hannun

Cláudia Rosso Felipe

Alexandra Ferreira

et al.

Abstract: Conversion from TAC/STN to TAC/MPS or from EVR/STN to TAC/EVR was associated with significant pharmacokinetic changes in both TAC and EVR whole-blood trough concentrations due to known drug-to-drug interaction, which were associated with changes in efficacy and safety.

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Efficacy and Safety of Elective Conversion From Sotrastaurin (STN) to Tacrolimus (TAC) or Mycophenolate (MPS) in Stable Kidney Transplant Recipients

Abstract: Conversion from TAC/STN to TAC/MPS or from EVR/STN to TAC/EVR was associated with significant pharmacokinetic changes in both TAC and EVR whole-blood trough concentrations due to known drug-to-drug interaction, which were associated with changes in efficacy and safety.

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References 33 publications

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