Efficacy and safety of exchange transfusion as an adjunct therapy for severe <i>Plasmodium falciparum</i> malaria in nonimmune travelers: a 10‐year single‐center experience with a standardized treatment protocol

Genderen, Perry J.J. van; Hesselink, Dennis A.; Bezemer, Jacob M.; Wismans, Pieter J.; Overbosch, David

doi:10.1111/j.1537-2995.2009.02488.x

Cited by 49 publications

(37 citation statements)

References 22 publications

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“…In striking contrast, in non-endemic industrialized countries malaria is seen as an occasionally imported disease in non-immune travellers, but it still represents a potentially fatal disease [2,3]. Without prompt and proper treatment malaria may rapidly progress to complications and even death.…”

Section: Introductionmentioning

confidence: 99%

A simple and fast method to exclude high Plasmodium falciparum parasitaemia in travellers with imported malaria

Gool

Wolfswinkel

Koelewijn

et al. 2011

Malar J

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BackgroundCounts of malaria parasites in peripheral blood are important to assess severity of Plasmodium falciparum malaria. Thin and thick smears are routinely used for this purpose.MethodsIn this study the Binax NOW® Malaria Test, an easy-to-perform rapid diagnostic test, with Histidine Rich Protein-2 (HRP-2) and aldolase as diagnostic markers, was used for semi-quantitative assessment of parasitaemia of P. faciparum.ResultsIn 257 patients with imported P. falciparum malaria, reactivity of aldolase increased with higher parasitaemia. In all patients with a parasitaemia above 50,000 asexual parasites/μl (> 1%) co-reactivity of HRP-2 and aldolase was observed. Absence of aldolase reactivity in the presence of HRP-2 was a reliable predictive marker to exclude high (> 1%) parasitaemia in P. falciparum malaria.ConclusionsAssessment of HRP-2 and aldolase co-reactivity can be of help in clinical decision making in the acute care setting of returning travellers suspected of having malaria.

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Section: Introductionmentioning

confidence: 99%

A simple and fast method to exclude high Plasmodium falciparum parasitaemia in travellers with imported malaria

Gool

Wolfswinkel

Koelewijn

et al. 2011

Malar J

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“…ET with healthy donor erythrocytes may improve microvascular diseases and oxygen-carrying capacity. 8 Published data about the effectiveness of ET is controversial. Several case reports have described the successful use of ET as an adjunctive therapy for severe malaria.…”

Section: Discussionmentioning

confidence: 99%

“…Case fatalities were not observed in the ET group. 8 Adverse events of ET were rarely reported, but included fluid overload, transfusion reactions, metabolic disturbances like hypocalcemia, transmissible infection, bleeding, red blood cell alloantibody sensitization, acute respiratory distress syndrome, ventricular fibrillation, and hypotension. 13 Any adverse events did not develop in our patient.…”

Section: Discussionmentioning

confidence: 99%

Exchange Transfusion for Severe Imported Falciparum Malaria with Hyperparasitaemia: Case Report

Güleç¹,

Avcil²,

Ünlü³

et al. 2016

Turkiye Klinikleri J Case Rep

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156 lasmodium falciparum malaria is the most dangerous form of malaria. The World Health organization (WHO) defines severe P. falciparum malaria as one or more of the following features: cerebral malaria, hyperparasitemia (>5% parasitized erythrocytes or >250.000 parasites/µl), severe anemia (hematocrit <15% or hemoglobin <5 g/dL in the presence of parasitemia >10,000 parasites/µL), renal failure (urine output <400 mL/24 hours in adults, with serum creatinine >3 mg/dL), respiratory distress and pulmonary edema, hypoglycemia (whole blood glucose <2.2 mmol/L or <40 Exchange Transfusion for Severe Imported Falciparum Malaria with Hyperparasitaemia: Case Report A AB BS ST TR RA AC CT T Severe falciparum malaria is a potentially fatal infection despite optimal antimalarial treatment. Exchange transfusion is successfully used in severe falciparum malaria with hyperparasitaemia. In this paper, we describe a case of severe Plasmodium falciparum infection in a 23-yearold man. The patient was referred to our emergency department with high fever after returning from Equatorial Guinea. The thin and thick blood smears revealed the presence of P. falciparum ring forms with a parasite density of 30%. P. falciparum infection was confirmed by Polymerase Chain Reaction (PCR). The patient was successfully treated by exchange transfusion in addition to antimalarial chemotherapy. Despite limited evidence of its efficacy in improving survival, exchange transfusion can be used as an-supportive treatment in selected cases where rapid reduction in the parasite load appears necessary.K Ke ey y W Wo or rd ds s: : Malaria; malaria, falciparum; exchange transfusion, whole blood; parasite load Ö ÖZ ZE ET T Şiddetli falsiparum sıtması uygun antimalaryal tedaviye rağmen potansiyel öldürücü bir enfeksiyondur. Exchange transfüzyon hiperparazitemili şiddetli falsiparum malarya olgularında başarıyla kullanılmaktadır. Bu yazıda şiddetli Plasmodium falciparum enfeksiyonu olan 23 yaşında bir erkek olgu tanımladık. Hasta, Ekvator Ginesi'nden döndükten sonra yüksek ateş ile acil servisimize başvurdu. İnce ve kalın yaymalarda %30 parazit yükü ile P. falciparum taşlı yüzük formları saptandı. P. falciparum enfeksiyonu polimeraz zincir reaksiyonu (PCR) ile doğrulandı. Olgu antimalaryal kemoterapiye ek olarak exchange transfüzyon ile başarılı bir şekilde tedavi edildi. Sağkalımı iyileştirmedeki etkinliği ile ilgili veriler kısıtlı olsa da yüksek parazit yükünün hızla azaltılması gereken seçilmiş olgularda, exchange transfüzyon destek tedavisi olarak uygulanabilir.A An na ah ht ta ar r K Ke ek ki im me er rl l: : Sıtma; sıtma, falsiparum; transfüzyon, tam kan; parazit yükü T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J C Ca as se e R Re ep p 2 20 01 16 6; ;2 24 4( (2 2) ): :1 15 56 6--6 60 0Güliz UYAR GÜLEÇ,

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“…İlaç tedavisinin yetersiz kaldığı vakalarda terapötik eritrositoferez tedavisinin başarılı olduğu bildirilmiştir (14,15). Bu olgulardan birinde de tedaviye yeterli yanıt alınamayınca Exchange Transfussion(ET) uygulanmış ve başarılı sonuç alınmıştır.…”

Section: Yöntemlerunclassified

Evaluating of Plasmodium Species Isolated From Peripheral Blood Samples in a Non-Endemic Region

Karadağ

Ünal²,

Yanık³

et al. 2015

TurkiyeParazitolDerg

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Efficacy and safety of exchange transfusion as an adjunct therapy for severe Plasmodium falciparum malaria in nonimmune travelers: a 10‐year single‐center experience with a standardized treatment protocol

Cited by 49 publications

References 22 publications

A simple and fast method to exclude high Plasmodium falciparum parasitaemia in travellers with imported malaria

A simple and fast method to exclude high Plasmodium falciparum parasitaemia in travellers with imported malaria

Exchange Transfusion for Severe Imported Falciparum Malaria with Hyperparasitaemia: Case Report

Evaluating of Plasmodium Species Isolated From Peripheral Blood Samples in a Non-Endemic Region

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