Efficacy and safety of felbamate in children under 4 years of age: a retrospective chart review

Grosso, Salvatore; Cordelli, Duccio Maria; Coppola, Giangennaro; Franzoni, Emilio; Verrotti, Alberto; Berardi, Rosario; Balestri, Paolo

doi:10.1111/j.1468-1331.2008.02215.x

Cited by 14 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Grosso et al evaluated 53 children under the age of 4 years on FBM therapy. Somnolence was reported in 13% of patients; an additional 9% of patients had unspecified sleep disturbance complaints [58]. In some epileptic patients felbamate precipitated insomnia with acute and chronic therapy [10].…”

Section: Effect Of Aeds On Sleep Architecturementioning

confidence: 99%

Epilepsy, Antiseizure Therapy, and Sleep Cycle Parameters

Shvarts

Chung

2013

Epilepsy Research and Treatment

View full text Add to dashboard Cite

A reciprocal relationship exists between sleep and epilepsy. The quality of sleep is affected by the presence and frequency of seizures, type of antiepileptic therapy utilized, and coexisting primary sleep disorders. Daytime somnolence is one of the most common adverse effects of antiepileptic therapy, with specific pharmacologic agents exhibiting a unique influence on components of sleep architecture. The newer generation of antiseizure drugs demonstrates improved sleep efficiency, greater stabilization of sleep architecture, prolongation of REM sleep duration, and increased quality of life measures. The emerging field of chronoepileptology explores the relationship between seizures and circadian rhythms, aiming for targeted use of antiseizure therapies to maximize therapeutic effects and minimize the adverse events experienced by the patients.

show abstract

Section: Effect Of Aeds On Sleep Architecturementioning

confidence: 99%

Epilepsy, Antiseizure Therapy, and Sleep Cycle Parameters

Shvarts

Chung

2013

Epilepsy Research and Treatment

View full text Add to dashboard Cite

show abstract

“…+ [50] Nausea + [51] + [53] + [62] + [44] + [34,47] + [41][42][43] + [37] + [38] Vomiting + [39] + [32] + [44] + [34,47,48] + [41,42] + [50] Continued next page…”

Section: Most Frequent Dose-related Adverse Effects To Antiepileptic mentioning

confidence: 99%

“…+ [52] Depression + [31] + [53] + [52,54] Suicidal ideation + [53] Behavioural problems + [39,55] + [30,56] + [51,57] + [40] + [32,58] + [59,60] + [45] + [46] + [41][42][43] + [35] + [36,37,49,52] + [38,50] Hallucinations/psychosis + [37] Blurred vision/visual field deficits + [51,63] + [53] Diplopia/eye movement abnormalities…”

Section: Most Frequent Dose-related Adverse Effects To Antiepileptic mentioning

confidence: 99%

“…Unauthorised copying and distribution is prohibited. + [33] + [34] + [35] + [36,37] + [38] Insomnia + [39] + [40] + [41][42][43] Somnolence + [39] + [30,31] + [40] + [32] + [33,44,45] + [46] + [34,47,48] + [41][42][43] + [35] + [36,49] + [50] Sedation + [51] Concentration problems + [36] Aphasia/dysarthria…”

Section: Most Frequent Dose-related Adverse Effects To Antiepileptic mentioning

confidence: 99%

See 1 more Smart Citation

Safety and Tolerability of Antiepileptic Drug Treatment in Children with Epilepsy

et al. 2012

View full text Add to dashboard Cite

“…More common side effects include anorexia, somnolence, insomnia, vomiting, weight loss, nausea, and gait abnormality. The risk of adverse events may be reduced by slow titration [8]. …”

Section: Introductionmentioning

confidence: 99%

Newer Anticonvulsant Medications in Pediatric Neurology

Quach

Mazin

Riviello

2010

Curr Treat Options Neurol

View full text Add to dashboard Cite

Antiepileptic drugs (AEDs) are the mainstay of treatment for recurrent seizures. Uncontrolled seizures may cause medical, developmental, and psychological disturbances. The medical practitioner should thus strive to eliminate or minimize seizures. Treatment advances in epilepsy include 1) identification of the basic mechanisms of epilepsy and action of AEDs, 2) the introduction of new AEDs, and 3) the use of neurostimulation, including vagus nerve stimulation. Treatment with AEDs involves balancing each AED's efficacy against its side effects. In some patients, effective AEDs must be discontinued because of intolerable side effects. Although all AEDs have a proven efficacy, the choice of AEDs should be based on better efficacy for individual seizure types or epilepsy syndromes. Side effects also differ from drug to drug and must be taken into account. This article focuses on studies and expert opinion consensus to guide the choice of AEDs.

show abstract

Efficacy and safety of felbamate in children under 4 years of age: a retrospective chart review

Abstract: Felbamate is an effective medication for a wide range of epilepsy syndromes in children younger than 4 years. Although caution is necessary when the drug is used in children, felbamate might represent a possible option for the treatment of epilepsy in this age group.

Cited by 14 publications

References 32 publications

Epilepsy, Antiseizure Therapy, and Sleep Cycle Parameters

Epilepsy, Antiseizure Therapy, and Sleep Cycle Parameters

Safety and Tolerability of Antiepileptic Drug Treatment in Children with Epilepsy

Newer Anticonvulsant Medications in Pediatric Neurology

Contact Info

Product

Resources

About