Efficacy and safety of fermented oyster extract for height of children with short stature: A randomized placebo-controlled trial

Jeong, Aram; Park, Beom Chan; Choi, Jun‐Yong; Cheon, Jin-Hong; Park, Joung-Hyun; Lee, Bae-Jin; Kim, Ki Bong

doi:10.1016/j.imr.2020.100691

Cited by 8 publications

(7 citation statements)

References 25 publications

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“…Therefore, it is necessary to consider this important result in future ISS intervention studies. Finally, according to a previous study, 40 minimal clinically important differences (MCID) for GV per 6 months were reported to be 0.51 cm; however, this was for children with mild short stature under the 25th percentile. Therefore, future studies on MCID calculation for GV in ISS patients will help clinicians with decision-making.…”

Section: Discussionmentioning

confidence: 89%

Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children: Systematic review and network meta-analysis

Lee

Kwon

Jang

2022

Integrative Medicine Research

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Background Idiopathic short stature (ISS) is a common problem in children and causes many economic and social burdens. In Asian countries, East Asian traditional medicine (EATM) therapies are widely used for children with ISS. In this study, we compared and ranked various EATM therapies for the treatment of pediatric ISS using network meta-analysis. Methods Randomized controlled trials that evaluated various EATMs for pediatric ISS were found through searching 14 electronic databases. The primary outcome was growth velocity (GV). The comparative effectiveness of the treatments was ranked based on the surface under the cumulative ranking curve (SUCRA) and the risk of bias was assessed. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development, and Evaluations approach. Results Fourteen studies comprising 1,066 participants were included. HM plus GH showed statistically significant superiority over other EATM therapies including acupuncture (weighted mean difference (WMD) 3.20 cm, 95% confidence interval (CI) 0.40 to 5.99) and HM (WMD 3.70 cm, 95% CI 1.41 to 5.99) for improving GV per year, although there was no difference compared with GH alone (WMD 1.18 cm, 95% CI -0.27 to 2.63). SUCRA indicated that HM plus GH was the most effective therapy for increasing GV, followed by GH, HM plus acupressure, and HM. No serious adverse events were reported. Conclusion For the treatment of ISS, HM plus GH might have a large beneficial effect and might be a better option than EATM therapies and GH alone. However, more long-term, high-quality trials are warranted to confirm the findings. Protocol registration PROSPERO ( https://www.crd.york.ac.uk/prospero/ ), CRD42020187160.

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Section: Discussionmentioning

confidence: 89%

Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children: Systematic review and network meta-analysis

Lee

Kwon

Jang

2022

Integrative Medicine Research

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“…GABA is the main inhibitory neurotransmitter in the central nervous system, and by blocking the chemical messages and delaying the stimulation of the nerve cells, it can affect several functions in the body, including muscle health. Previous studies have shown that enriched GABA contents after being fermented by Lactobacillus brevis BJ-20 ( L. brevis BJ-20) had a positive effect on height growth [ 11 ], bone formation [ 12 ], and muscle endurance [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Fermented Sarco Oyster (Crassostrea gigas) Extract on Muscle Strength Enhancement in Postmenopausal Females: A Randomized, Double-Blind, Placebo-Controlled Trial

Rheu¹,

Lee²,

Son

et al. 2022

IJERPH

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A randomized controlled trial (RCT) was conducted to evaluate the effect of fermented sarco oysters (FSO) on muscle strength in postmenopausal females with low muscle mass. Fifty-two female participants were randomly divided into the experiment group (EG) or control group (CG). For 12 weeks, the EG was subjected to 1000 mg of FSO extract daily while the CG consumed the placebo extract. The muscle extension and flexion at an angular velocity of 60°/s and with respect to grip strength, body composition, and muscle growth-related blood factors were measured at the baseline and after the trial. The difference in the quadriceps muscle extension at an angular velocity of 60°/s, grip strength on both the left and right side, and insulin-like growth factor-1(IGF-1) between groups were significantly higher in the EG compared with the CG. However, no differences were found in body composition, blood pyruvate, lactate, or high-sensitivity C-reactive protein (hsCRP) concentration between the two groups. In conclusion, FSO supplements may improve muscle strength in postmenopausal females with relatively reduced muscle strength without a change in muscle mass.

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“…They also contain a large amount of phosphorus taurine (based on a 4.2%/dry base) and represent one of the world’s top 10 seafood foods rich in essential minerals such as glycogen, vitamins, iron, and iodine ( 6 ). Recently, the effects of lactic acid-fermented oyster extract (FO) containing GABA and lactic acid, produced by lactic acid fermentation of oysters, on bone formation ( 7 ), height growth ( 8 ), and exercise performance improvement ( 9 ) have been reported. Also, a previous study showed that GABA-enriched FO reduced muscle proteolysis by increasing mRNA levels of IGF-1 expression in dexamethasone-treated animals ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of fermented oyster (Crassostrea gigas) extracts and regular walking on muscle strength and mass in older adults with relatively low muscle mass: A randomized controlled trial

Lee¹,

Lee

2022

Front. Nutr.

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IntroductionOysters possess an excellent nutritional profile containing γ-aminobutyric acid (GABA). Previous data suggest that GABA is a potent bioactive compound for improving muscle health. Lactic acid fermentation is thought to increase GABA content. However, the effect of oral supplementation of fermented oyster extracts (FO) on human muscle strength and mass is unclear. Therefore, we tested the effects and safety of consumption of FO combined with regular walking for 12 weeks on muscle strength and mass in older adults with relatively low muscle mass.Materials and methodsA randomized controlled trial was conducted on 54 adults between 50 and 78 years of age. Participants were randomized to receive either placebo or 1,200 mg FO daily for 12 weeks. By fermentation with Lactobacillus brevis BJ20, FO was prepared from Crassostrea gigas. At baseline and at 12 weeks after treatment, the following parameters of the participants were examined: knee strengths, handgrip strengths, body composition, blood tests, and 24-h dietary recall. All participants were required to walk for 30–60 min/day for >3 days/week during the trial period. Physical activity was assessed using an exercise log during the study.ResultsOf the 54 participants, 49 completed the trial without reporting adverse effects. FO supplementation over 12 weeks did not cause any increase in knee or grip strength compared to the control group. Also, no differences were observed in the muscle mass, growth hormone, muscle biomarkers, anti-inflammatory markers, and antioxidative markers between the two groups. None of the participants experienced adverse events. Application of FO was well tolerated, and no notable adverse effect was reported in both groups.DiscussionFO supplementation with regular walking did not improve remarkably muscle function compared to regular walking alone in adults with relatively low muscle mass.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT04109911].

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Efficacy and safety of fermented oyster extract for height of children with short stature: A randomized placebo-controlled trial

Cited by 8 publications

References 25 publications

Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children: Systematic review and network meta-analysis

Comparative effectiveness of East Asian traditional medicine for treatment of idiopathic short stature in children: Systematic review and network meta-analysis

Effect of Fermented Sarco Oyster (Crassostrea gigas) Extract on Muscle Strength Enhancement in Postmenopausal Females: A Randomized, Double-Blind, Placebo-Controlled Trial

Effect of fermented oyster (Crassostrea gigas) extracts and regular walking on muscle strength and mass in older adults with relatively low muscle mass: A randomized controlled trial

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