Efficacy and safety of Fufangkushen colon-coated capsule in the treatment of ulcerative colitis compared with mesalazine: A double-blinded and randomized study

Yang, Gong; Zha, Qinglin; Li, Li; Liu, Yan; Yang, Bo; Liu, Liang; Lü, Aiping; Li, Yifan; Jiang, Miao

doi:10.1016/j.jep.2011.08.057

Cited by 52 publications

(27 citation statements)

References 29 publications

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“…Recently, the importance of using natural products has increased, as has the interest in discovering safe and efficient new drugs to treat inflammatory conditions [ 14 ]. Studies have investigated the use of natural products in the treatment of various inflammatory diseases such as asthma [ 15 ], ulcerative colitis [ 16 ], Crohn's disease [ 17 ], and bone loss in inflammatory conditions such as periodontitis [ 9 ]. Of these products, flavonoids contained in fruits and vegetables have been found to be very active as anti-inflammatory agents [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Allium cepaL. and Quercetin Inhibit RANKL/Porphyromonas gingivalisLPS-Induced Osteoclastogenesis by Downregulating NF-κB Signaling Pathway

Oliveira

Figueiredo

Brito

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Objectives. We evaluated the in vitro modulatory effects of Allium cepa L. extract (AcE) and quercetin (Qt) on osteoclastogenesis under inflammatory conditions (LPS-induced). Methods. RAW 264.7 cells were differentiated with 30 ng/mL of RANKL, costimulated with PgLPS (1 µg/mL), and treated with AcE (50–1000 µg/mL) or Qt (1.25, 2.5, or 5 µM). Cell viability was determined by alamarBlue and protein assays. Nuclei morphology was analysed by DAPI staining. TRAP assays were performed as follows: p-nitrophenyl phosphate was used to determine the acid phosphatase activity of the osteoclasts and TRAP staining was used to evaluate the number and size of TRAP-positive multinucleated osteoclast cells. Von Kossa staining was used to measure osteoclast resorptive activity. Cytokine levels were measured on osteoclast precursor cell culture supernatants. Using western blot analysis, p-IκBα and IκBα degradation, inhibitor of NF-kappaB, were evaluated. Results. Both AcE and Qt did not affect cell viability and significantly reduced osteoclastogenesis compared to control. We observed lower production of IL-6 and IL-1α and an increased production of IL-3 and IL-4. AcE and Qt downregulated NF-κB pathway. Conclusion. AcE and Qt may be inhibitors of osteoclastogenesis under inflammatory conditions (LPS-induced) via attenuation of RANKL/PgLPS-induced NF-κB activation.

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Section: Introductionmentioning

confidence: 99%

Allium cepaL. and Quercetin Inhibit RANKL/Porphyromonas gingivalisLPS-Induced Osteoclastogenesis by Downregulating NF-κB Signaling Pathway

Oliveira

Figueiredo

Brito

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…For a long time, UC has been regarded as mainly prevalent in the Western countries [ 9 – 11 ]; however, recently, a growing number of data showed that the incidence of this disease is significantly higher than before in Asia [ 12 – 14 ]. Chinese medicine (CM), as an essential part of the healthcare system in several Asian countries, has shown a promising clinical effect in the treatment of UC patients [ 15 , 16 ]. Generally, a successful treatment for UC with Chinese medicine is based on the syndrome differentiation, which is one of the most important concepts in the practice of Chinese medicine theory.…”

Section: Introductionmentioning

confidence: 99%

The Th17/Treg Immune Balance in Ulcerative Colitis Patients with Two Different Chinese Syndromes: Dampness-Heat in Large Intestine and Spleen and Kidney Yang Deficiency Syndrome

Yang

Liu

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients with two Chinese syndrome: dampness-heat in large intestine (DHLI) and spleen and kidney Yang deficiency (SKYD). Methods. Ninety UC patients (45 were diagnosed with DHLI and 45 with SKYD syndrome) and 23 healthy people were recruited. The serumIL-17 and TGF-β1 levels of these participants were measured with ELISA; the expression of IL-17 and TGF-β 1 in colonic mucosa tissue was determined with immunohistochemistry and the percentage of Th17 and Treg in peripheral blood with flow cytometry. Results. The levels of IL-17 and Th17 were significantly higher in both DHLI and SKYD groups than in healthy control group and higher in DHLI than in SKYD group (P < 0.05). The levels of TGF-β1 and Treg were significantly lower in the two UC patients groups than in healthy control group; and lower in SKYD group than in DHLI group (P < 0.05). Conclusions. UC with DHLI syndrome could be characterized by the elevation of Th17 and IL-17 levels, which indicated an accentuation of inflammatory reaction; UC with SKYD syndrome could be characterized by the reduction of serum Treg and TGF-β1 levels, which represented a depression of immune tolerance.

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“…Traditional Chinese medicine (TCM) is widely used to treat UC as a complementary and alternative medicine [ 10 – 16 ]. Some clinical research has reported that TCM therapies are effective for treating UC patients with LIDHS in the clinic [ 8 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Development of a Traditional Chinese Medicine Syndrome‐Specific Scale for Ulcerative Colitis: The Large Intestine Dampness‐Heat Syndrome Questionnaire

Chen

Wen

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to develop and validate the large intestine dampness-heat syndrome questionnaire (LIDHSQ) for patients with ulcerative colitis (UC). The domains and items of the LIDHSQ were developed according to standard procedures, namely, construct definition, item generation, language testing, content validity, pilot study, and validation study. At first, a total of 20 items in 3 domains were generated based on literature review and expert consultation. After the item selection, the LIDHSQ contains 11 items in three domains: disease-related domain (diarrhoea, abdominal pain, bloody purulent stool, and mucus stool), heat domain (fever, dry mouth, red tongue, yellow fur, and anal burning), and dampness domain (greasy fur and defecation disorder). The Cronbach's alphas of all domains were greater than 0.6. All of the intraclass correlation coefficients were greater than 0.8. The LIDHSQ and domain scores of the patients with LIDHS were higher than those of the patients with other syndromes (P < 0.001). The area under the receiver operating characteristic curve of the LIDHSQ was 0.900, with a 95% confidence interval of 0.872–0.928. When the cut-off value of the LIDHSQ was ≥ 7, the sensitivity and specificity were 0.867 and 0.854, respectively. The LIDHSQ is valid and reliable for measuring LIDHS in UC patients with good diagnostic efficacy. We recommend the use of the LIDHSQ in Chinese UC patients.

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Efficacy and safety of Fufangkushen colon-coated capsule in the treatment of ulcerative colitis compared with mesalazine: A double-blinded and randomized study

Cited by 52 publications

References 29 publications

Allium cepaL. and Quercetin Inhibit RANKL/Porphyromonas gingivalisLPS-Induced Osteoclastogenesis by Downregulating NF-κB Signaling Pathway

Allium cepaL. and Quercetin Inhibit RANKL/Porphyromonas gingivalisLPS-Induced Osteoclastogenesis by Downregulating NF-κB Signaling Pathway

The Th17/Treg Immune Balance in Ulcerative Colitis Patients with Two Different Chinese Syndromes: Dampness-Heat in Large Intestine and Spleen and Kidney Yang Deficiency Syndrome

Development of a Traditional Chinese Medicine Syndrome‐Specific Scale for Ulcerative Colitis: The Large Intestine Dampness‐Heat Syndrome Questionnaire

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