Efficacy and safety of gatifloxacin in elderly outpatients with community-acquired pneumonia

Nicholson, Susan; Wilson, Walter R.; Naughton, Bruce J.; Gothelf, Samantha; Webb, Charles D.

doi:10.1016/s0732-8893(02)00465-0

Cited by 15 publications

(2 citation statements)

References 25 publications

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“…9,10 Gatifloxacin has been shown in clinical trials to be equivalent to b-lactam antibiotics in the treatment of various respiratory infections. 11,12 However, recent reports of dysglycemia in patients receiving gatifloxacin and the risk of selecting for resistance during and following therapy should be taken into consideration when selecting a therapeutic agent for respiratory infections. 13 For H. influenzae, the high rates of susceptibility to gatifloxacin can be extrapolated to other new-generation fluoroquinolones such as moxifloxacin.…”

mentioning

confidence: 99%

Antimicrobial susceptibility of respiratory pathogens at the American University of Beirut Medical Center

Kanj

El-Dbouni

Kanafani

et al. 2007

International Journal of Infectious Diseases

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mentioning

confidence: 99%

Antimicrobial susceptibility of respiratory pathogens at the American University of Beirut Medical Center

Kanj

El-Dbouni

Kanafani

et al. 2007

International Journal of Infectious Diseases

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“…In addition, there is a significant reduction in adverse effects with these agents [54,55]. In particular, gatifloxacin has been found to be safe and effective in very old patients including those with pneumococci resistant to penicillin [56]. The exact place of this group of agents for the treatment of elderly CAP patients differs when considering the recommendations of the ATS and the BTS.…”

Section: Antipneumococcal Fluoroquinolonementioning

confidence: 99%

Management of respiratory infections in the elderly

Lieberman¹,

Lieberman

2003

Expert Review of Anti-infective Therapy

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Respiratory infections are common at all ages but are particularly sinister among the elderly because of the fragility and chronic comorbidity associated with this age group. The three types of respiratory infection in the elderly are community-acquired pneumonia, acute exacerbation of chronic obstructive pulmonary disease and nonpneumonic respiratory tract infection. The etiology of these three types of infection includes classic bacteria, atypical pathogens and respiratory viruses. The relative frequency of each of the etiological groups as the causative agent of the infection varies significantly among these types of infection, but in all three types a significant proportion of infections involves more than one pathogen. The causative agent of respiratory infection in the elderly cannot be determined on the basis of clinical manifestation or the results of routine imaging procedures or laboratory tests. Thus, initial antibiotic therapy in these patients should be empiric, based on accepted guidelines. In recent years, the antipneumococcal fluoroquinolones have gained in stature as one of the best options to treat these infections. Pneumococcal and influenza vaccinations can reduce morbidity and mortality from respiratory infections in the elderly, so it is important that all elderly individuals are vaccinated through a structured program in the framework of primary care. The economic impact of respiratory infections in the elderly is primarily associated with the requirement for hospitalization in many of the cases. Any action that can reduce hospitalization rates has important economic ramifications. In light of the difficulty in reaching an early etiologic diagnosis in respiratory infections, it is essential to invest in the development of a compact diagnostic kit for the early stages of the disease, which could change reality in this important area of medicine.

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Gatifloxacin

2006

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions

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Efficacy and safety of gatifloxacin in elderly outpatients with community-acquired pneumonia

Cited by 15 publications

References 25 publications

Antimicrobial susceptibility of respiratory pathogens at the American University of Beirut Medical Center

Antimicrobial susceptibility of respiratory pathogens at the American University of Beirut Medical Center

Management of respiratory infections in the elderly

Gatifloxacin

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