Efficacy and safety of Gegen Qinlian decoction for normalizing hyperglycemia in diabetic patients: A systematic review and meta-analysis of randomized clinical trials

Ryuk, Jin Ah; Mu, Lixia; Cao, Shihua; Ko, Byoung‐Seob; Park, Sunmin

doi:10.1016/j.ctim.2017.05.004

Cited by 38 publications

(25 citation statements)

References 26 publications

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“…GQP is a classic TCM prescription in treating gastrointestinal diseases, such as dysentery, eneritis, ulcerative colitis [26]. In the previous study, Gegen Qinlian decoction extract has been shown to alleviate diarrhea induced by CPT-11 [10].…”

Section: Discussionmentioning

confidence: 98%

WITHDRAWN: Network Pharmacology-based to Investigate Pharmacological Mechanisms of Active Ingredients in Gegen Qinlian Pill to Ameliorate Irinotecan-induced Diarrhea

Cheng

Yang

et al. 2020

Preprint

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Background: The application of natural extracts or compounds derived from Chinese medicine is deemed to a promising strategy to prevent irinotecan (CPT-11)-induced gut toxicity. Based on the protective activity of Gegen Qinlian decoction in our previous study, we speculated that Gegen Qinlian Pill (GQP) would exhibit similar therapeutic effects. However, the effective material basis and the potential mechanisms underlying the effect of GQP in the treatment of diarrhea induced by CPT-11 have not been fully elucidated. Herein, we primarily investigated amelioration effect of GQP on the CPT-11 induced gut toxicity, and further explore its anti-diarrhea mechanism.Methods: Firstly, the protective effect of GQP towards alleviating diarrhea in mice following CPT-11 administration was investigated. Furthermore, the effective ingredients of GQP in serum sample of mice by HPLC-Q-TOF-MS analysis was obtained. Next, based on these active components, an interaction network linking “compound-target-pathway” was established. Finally, a predicted mechanism within vivo validation of GQP based on Gene Ontology (GO) functional and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were obtained. Results: A total of 19 chemical compounds derived from the GQP were identified in its serum sample. Then, an interaction network linking “compound-target-pathway” was established to illuminate the interaction between these components absorbed into serum and their targets for diarrhea. GQP exerted a curative effect on diarrhea and diarrhea-related diseases by targeting different targets, regulating inflammation, oxidative stress, and proliferation processes. Conclusion: Taken together, this study provides a novel and scientific strategy to discover the potential effective constituents of herbs or herbal formula, and elucidated basic pharmacological effects and underlying mechanisms of GQP in the treatment of CPT-11 induced gut toxicity.

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Section: Discussionmentioning

confidence: 98%

WITHDRAWN: Network Pharmacology-based to Investigate Pharmacological Mechanisms of Active Ingredients in Gegen Qinlian Pill to Ameliorate Irinotecan-induced Diarrhea

Cheng

Yang

et al. 2020

Preprint

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“…In 2017, the study of Ryuk et al [ 7 ] confirmed the synergistic effect of GQD plus metformin on glucose control, which included 5 RCTs with a total of 499 participants. In our study, which is based on the other three indicators (FPG, 2hPPG, and HbA1c), we further determine the effectiveness and safety of GQD in the treatment of T2DM.…”

Section: Discussionmentioning

confidence: 99%

Herbal Formula Gegen‐Qinlian Decoction for Type 2 Diabetes Mellitus: A Meta‐Analysis of Randomized Controlled Trials

Lin

Cheng

Qin

2020

Evidence-Based Complementary and Alternative Medicine

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Background. Herbal formula Gegen-Qinlian Decoction (GQD) has been widely used in China for the treatment of type 2 diabetes mellitus (T2DM), but its efficacy and safety are unclear. Method. The studies were identified from the PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure database, Wanfang database, and VIP database using the keywords “Gegenqinlian” or “Gegen-Qinlian” or “Gegen-Qin-Lian” or “Ge Gen Qin Lian.” Relevant studies were selected according to predefined inclusion and exclusion criteria. Study selection, data extraction, and validation were carried out by, at least, two reviewers with disagreements being settled by discussion. Results. After literature search, a total of 26 randomized controlled trials were included with a total of 2553 patients. There was evidence that compared with metformin, the combination of GQD and metformin significantly reduced the fasting plasma glucose levels (MD −1.79, 95% CI (−2.31, −1.27), p < 0.00001 ); 2-hour postprandial plasma glucose levels (MD −1.72, 95% CI (−2.12, −1.31), p < 0.00001 ); and glycosylated hemoglobin levels (MD −1.26, 95% CI (−1.80, −0.72), p < 0.00001 ), and no serious side effects were identified. Conclusion. These data suggest that GQD may be an effective herbal formula in treating T2DM without serious side effects. The addition of GQD also enhances the hypoglycemic effects of metformin. However, the evidence remains weak due to methodological flaws, which may amplify the therapeutic benefit of GQD.

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“…For example, in Thailand and some other Asian countries, Rhinacanthus nasutus (L.) Kurz has traditionally been used in treating various disorders including diabetes, and rhinacanthins, the extract of R. nasutus , had been confirmed to have significant anti-hyperglycemia, anti-hyperlipidemia, and antiobesity effects, which was considered as a potential candidate for antidiabetic drug development [ 26 – 28 ]. In China, the Scutellaria - Coptis (SC) herbal pair is the basic component of many herbal formulas used for treating diabetes [ 29 ]. Pharmacological studies have confirmed that the flavonoids in Scutellaria baicalensis and the alkaloids in Coptis chinensis are the main material basis for ameliorating T2D, and their therapeutic mechanisms involve anti-inflammatory effects and the regulation of the gut microbiota [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota

Zhang

Yue

Chen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Recent studies have confirmed that increased intestinal permeability and gut-origin lipopolysaccharide (LPS) translocation are important causes of metabolic inflammation in type 2 diabetes (T2D), but there are no recognized therapies for targeting this pathological state. Scutellaria baicalensis and Coptis chinensis are a classic herbal pair often used to treat diabetes and various intestinal diseases, and repair of intestinal barrier damage may be at the core of their therapeutic mechanism. This study investigated the effects of oral administration of Scutellaria-Coptis (SC) on the intestinal mucosal barrier in diabetic rats and explored the underlying mechanism from the perspective of anti-inflammatory and gut microbiota-modulatory effects. The main results showed that, in addition to regulating glycolipid metabolism disorders and inhibiting serum inflammatory factors, SC could also upregulate the expression levels of the tight junction proteins claudin-1, occludin, and zonula occludens (ZO-1), significantly improve intestinal epithelial damage, and inhibit excessive LPS translocation into the blood circulation. Furthermore, it was found that SC could reduce the levels of the inflammatory factors interleukin-1β (IL-1β), IL-6, and tumour necrosis factor-α (TNF-α) in intestinal tissue and that the anti-inflammatory effects involved the TLR-4/TRIF and TNFR-1/NF-κB signalling pathways. Moreover, SC had a strong inhibitory effect on some potential enteropathogenic bacteria and LPS-producing bacteria, such as Proteobacteria, Enterobacteriaceae, Enterobacter, Escherichia-Shigella, and Enterococcus, and could also promote the proliferation of butyrate-producing bacteria, such as Lachnospiraceae and Prevotellaceae. Taken together, the hypoglycaemic effects of SC were related to the protection of the intestinal mucosal barrier, and the mechanisms might be related to the inhibition of intestinal inflammation and the regulation of the gut microbiota.

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Efficacy and safety of Gegen Qinlian decoction for normalizing hyperglycemia in diabetic patients: A systematic review and meta-analysis of randomized clinical trials

Cited by 38 publications

References 26 publications

WITHDRAWN: Network Pharmacology-based to Investigate Pharmacological Mechanisms of Active Ingredients in Gegen Qinlian Pill to Ameliorate Irinotecan-induced Diarrhea

WITHDRAWN: Network Pharmacology-based to Investigate Pharmacological Mechanisms of Active Ingredients in Gegen Qinlian Pill to Ameliorate Irinotecan-induced Diarrhea

Herbal Formula Gegen‐Qinlian Decoction for Type 2 Diabetes Mellitus: A Meta‐Analysis of Randomized Controlled Trials

The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota

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