Efficacy and safety of ginkgo preparation in patients with vascular dementia

Abstract

Background: Vascular dementia has become the second most common type of dementia after Alzheimer disease. At present, there is no uniform standard for VaD treatment guidelines among countries. The efficacy of ginkgo biloba in the treatment of vascular dementia is still controversial. The purpose of this study is to evaluate the effectiveness and safety of ginkgo biloba in the treatment of vascular dementia through meta-analysis. Methods: Six English databases (PubMed, Web of science, Medline, EBASE, Springer Cochrane Library, and WHO International Clinical Trials Registry Platform) and 4 Chinese databases (Wan fang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database(CNKI) and Chinese Biomedical Literature Database) will be searched normatively according to the rule of each database from the inception to August 1, 2020. Two reviewers will independently conduct article selection, data collection, and risk of bias evaluation. Any disagreement will be resolved by discussion with the third reviewer. Either the fixed-effects or random-effects model will be used for data synthesis based on the heterogeneity test. The change in the scores on mini-mental state examination, activity of daily living scale and Montreal cognitive assement will be used as the main outcome measure, Hamilton depression scale, Hastgawa dementia scale, blessed dementia scale, clinical dmentia rating scale as the secondary outcome. Treatment emergent symptom scale, general physical examination (temperature, pulse, respiration, blood pressure), Routine examination of blood, urine and stool, electrocardiogram, liver and kidney function examination as the security indexs. RevMan5.3.5 will be used for meta-analysis. Results: This study will provide high-quality evidence to assess the effectiveness and safety of ginkgo preparation for vascular dementia. Conclusion: This systematic review will explore whether ginkgo preparation is an effective and safe intervention for vascular dementia. Ethics and dissemination: Ethical approval are not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and will be shared on social media platforms. This review will be disseminated in a peer-reviewed journal or conference presentation. PROSPERO registration number: PROSPERO CRD42020167851.

Neuronutrición: repercusiones de los excesos y de las deficiencias nutricionales

“…Otros estudios preclínicos y clínicos han demostrado el efecto positivo del ginkgo biloba para mejorar las capacidades cognitivas en personas con cierta discapacidad, así como para reducir los TAG (90)(91)(92) .…”

Bioactive Compounds and Traditional Herbal Medicine: Promising Approaches for the Treatment of Dementia

“…26 Furthermore, a meta-analysis study by Wang et al proved that Gb could be an effective treatment for vascular dementia. 27 Another meta-analysis study explored the efficacy of EGb 761 in dementia patients treated with 120 mg or 240 mg per day when compared to placebo. The study results showed that EGb 761 was well tolerated in all trials and that 240 mg of EGb 761 was more effective in improving cognition.…”

Efficacy and safety of herbal medicine on dementia and cognitive function: An umbrella review of systematic reviews and meta‐analysis

“…This method can help summarize the evidence from multiple systematic reviews and meta‐analyses, assessing the strength of evidence and extent of possible biases to ascertain the quality of evidence. To date, several systematic reviews and meta‐analyses (SRMAs) focusing on the antidementia effects of herbal medicines and medicinal plants have been recently reported (Hussain et al, 2022; Liao et al, 2020; Wang et al, 2020; Zhu, Mei, Zhang, Xie, & Lang, 2019). To synthesise the most updated comprehensive evidence, we performed the umbrella review to systematically summarize the effects of various types of herbal medicines used for improving cognitive function in healthy volunteer or patients with dementia for determining benefits of each herb from previously published systematic reviews and meta‐analyses to provide the wide picture for real‐world clinical practice.…”