Efficacy and safety of herbal medicine (Dangguijagyag-san) for primary dysmenorrhea: study protocol for a randomized, double-blind, placebo-controlled, parallel-group, multi-center trial

Woo, Hye Lin; Ji, Hae Ri; Kim, Siin; Suh, Hae Sun; Lee, Beom-Joon; J, Lee; Park, Kyoung Sun

doi:10.1016/j.imr.2020.02.002

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…Rhizoma Atractylodis Macrocephalae, Poria cocos and Rhizoma Alismatis can invigorate the spleen, remove dampness and have a diuretic effect. This prescription is commonly used in modern Chinese medicine to treat PD, and the curative effect is remarkable (Woo et al, 2020). It can be observed that the 12 specific components meet the compatibility principle of prescription.…”

Section: Discussionmentioning

confidence: 99%

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Integrated UPLC–Q‐TOF–MS and network pharmacology approach‐driven quality marker discovery of Danggui Shaoyao San for primary dysmenorrhea

Xiong

et al. 2023

Biomedical Chromatography

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Danggui Shaoyao San (DSS), a famous prescription, has been clinically proved to be effective in treating primary dysmenorrhea (PD). Currently there is no valid quality control data available for DSS. The main aim of the current research was to explore quality markers (Q-markers) of DSS. The chemical constituents of DSS were qualitatively identified using ultra-performance liquid chromatography tandem quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS) technology. On this basis, the targets of DSS and PD were predicted and screened using the TCMSP, SwissTarget-Prediction, GeneCards, OMIM and TTD databases. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis was performed on the core intersection targets using string and Cytoscape 3.7.1 software. Then molecular docking was conducted to screen the Q-markers of DSS in PD. A total of 126 chemical constituents, including 22 organic acids, 14 phthalides, 24 monoterpenoids, five sesquiterpene lactones, 22 triterpenoids, four phenylpropanoids and 35 other compounds were preliminarily characterized. According to network pharmacology prediction analysis, six compounds containing polyporenic acid C, senkyunolide P, alisol B 23-acetate, naringenin, gallic acid, ferulic acid and albiflorin were regarded as Q-markers of DSS. The present research established an integrative UPLC-Q-TOF-MS and network pharmacology method to discover the latent Q-markers of DSS and provided a theoretical data for the follow-up quality control of DSS. | INTRODUCTIONPrimary dysmenorrhea (PD) is characterized by lower abdominal pain, swelling and waist acid before and after menstruation or during menstruation, and refers to the absence of organic lesions in the reproductive organs. In severe cases, nausea and vomiting, sweating and even fainting may occur, which can affect the normal life of patients, which is mostly seen in adolescent women (Sharghi et al., 2019). The pathogenesis of PD is complex, and is considered to be mainly related to the fluctuation of prostaglandin (PG), estrogen and progesterone in the endometrium during menstruation (Dawood, 2006). In modern medicine, nonsteroidal anti-inflammatory drugs, oral contraceptives, calcium channel blockers, vitamins and other drugs are used to regulate the endocrine system and alleviate abnormal contractions of

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Section: Discussionmentioning

confidence: 99%

“…It has the function of nourishing the blood and calming the liver, relieving pain and strengthening spleen and diuresis (Shen et al, 2005). It is clinically applied for the treatment of gynecological diseases, such as PD (Woo et al, 2020). Compared with Western medicine, TCM plays a crucial tole in PD treatment.…”

mentioning

confidence: 99%

Integrated UPLC–Q‐TOF–MS and network pharmacology approach‐driven quality marker discovery of Danggui Shaoyao San for primary dysmenorrhea

Xiong

et al. 2023

Biomedical Chromatography

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Cnidium officinale Makino: Phytology, Phytochemistry, Toxicology, Pharmacology and Prescriptions (1967–2023)

Ma,

Liu,

Wang

et al. 2023

Chemistry & Biodiversity

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Cnidium officinale Makino (COM), a perennial herbaceous plant in the Apiaceous family, widely distribute in Eastern Asia and Asia‐Temperate. It has a long history application as a traditional medicine for invigorating the blood and removing blood stasis, and also has been employed to diet, pesticide, herbal bathing materials, the cosmetic and skin care industry. However, there has been no associated review of literature in the past half a century (1967–2023). By searching the international authoritative databases and collecting 229 literatures closely related to COM, herewith a comprehensive and systematic review was conducted. The phytology includes plant distribution and botanical characteristics. The phytochemistry covers 8 major categories, 208 compounds in total, and the quantitative determination of 14 monomer compounds, total polyphenols and total flavonoids. The clinical trial in pregnant women and toxic experiments in mice, the pharmacology of 7 aspects and 82 frequently used prescriptions are summarized. It is expected that this paper will provide forward‐looking scientific thinking and literature support for the further modern research, development and utilization of COM.

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Regulation and status of herbal medicine clinical trials in Korea

Lee

Choi

Kim

et al. 2021

Integrative Medicine Research

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Efficacy and safety of herbal medicine (Dangguijagyag-san) for primary dysmenorrhea: study protocol for a randomized, double-blind, placebo-controlled, parallel-group, multi-center trial

Cited by 4 publications

References 28 publications

Integrated UPLC–Q‐TOF–MS and network pharmacology approach‐driven quality marker discovery of Danggui Shaoyao San for primary dysmenorrhea

Integrated UPLC–Q‐TOF–MS and network pharmacology approach‐driven quality marker discovery of Danggui Shaoyao San for primary dysmenorrhea

Cnidium officinale Makino: Phytology, Phytochemistry, Toxicology, Pharmacology and Prescriptions (1967–2023)

Regulation and status of herbal medicine clinical trials in Korea

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